| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rock Springs Capital Management LP | 1,440,759 | 3,003,259 | +1,562,500 | 0.04 | 0.09 | +0.05 | buy |
| MORGAN STANLEY | 0 | 1,112,740 | +1,112,740 | 0.00 | 0.00 | +0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 2,805,413 | 3,785,450 | +980,037 | 0.24 | 0.39 | +0.15 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 84,826 | 182,855 | +98,029 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 249,446 | 295,000 | +45,554 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 33,289 | +33,289 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 15,690 | 43,390 | +27,700 | 0.00 | 0.00 | +0.00 | buy |
| Avantax Planning Partners, Inc. | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 17,798 | 39,208 | +21,410 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 13,271 | +13,271 | 0.00 | 0.00 | +0.00 | buy |
| SevenBridge Financial Group, LLC | 31,000 | 41,000 | +10,000 | 0.01 | 0.01 | -0.00 | buy |
| Pinnacle Financial Group, LLC / IL | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 902,531 | 902,531 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 71,081 | 71,081 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TAKEDA PHARMACEUTICAL CO LTD | 1,475,121 | 1,475,121 | 0 | 0.55 | 0.60 | +0.05 | hold |
| Qube Research & Technologies Ltd | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Key FInancial Inc | 830 | 830 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Dunhill Financial, LLC | 10,274 | 10,274 | 0 | 0.01 | 0.01 | -0.01 | hold |
| FIL Ltd | 218,705 | 218,705 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11,925 | 11,925 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 11,153 | 4,207 | -6,946 | 0.00 | 0.00 | -0.00 | sell |
| Summit Trail Advisors, LLC | 16,000 | 0 | -16,000 | 0.00 | 0.00 | -0.00 | sell |
| FNY Investment Advisers, LLC | 27,500 | 0 | -27,500 | 0.02 | 0.00 | -0.02 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 29,500 | 0 | -29,500 | 0.00 | 0.00 | -0.00 | sell |
| PFG Investments, LLC | 30,000 | 0 | -30,000 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 70,198 | 12,205 | -57,993 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 338,542 | 272,486 | -66,056 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,907,671 | 1,395,853 | -511,818 | 0.00 | 0.00 | -0.00 | sell |
| Atlas Venture Life Science Advisors, LLC | 992,912 | 0 | -992,912 | 0.10 | 0.00 | -0.10 | sell |