| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 0 | 592,300 | +592,300 | 0.00 | 0.11 | +0.11 | buy |
| Stonepine Capital Management, LLC | 64,162 | 225,994 | +161,832 | 0.47 | 1.65 | +1.17 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 111,541 | +111,541 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 17,544 | +17,544 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 49,566 | 64,153 | +14,587 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 14,544 | +14,544 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 11,600 | +11,600 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 0 | 8,757 | +8,757 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 37,197 | 39,055 | +1,858 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 714 | +714 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 115 | +115 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 152,464 | 152,464 | 0 | 0.18 | 0.25 | +0.07 | hold |
| Bain Capital Life Sciences Investors, LLC | 664,021 | 664,021 | 0 | 0.50 | 0.38 | -0.13 | hold |
| Key FInancial Inc | 59 | 59 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Velan Capital Investment Management LP | 14,285 | 14,285 | 0 | 0.08 | 0.08 | +0.01 | hold |
| Frazier Life Sciences Management, L.P. | 422,505 | 422,505 | 0 | 0.09 | 0.09 | -0.00 | hold |
| Merck & Co., Inc. | 105,982 | 105,982 | 0 | 0.26 | 0.19 | -0.06 | hold |
| GILEAD SCIENCES, INC. | 650,389 | 650,389 | 0 | 0.26 | 0.38 | +0.12 | hold |
| STATE STREET CORP | 13,311 | 13,311 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GSA CAPITAL PARTNERS LLP | 16,946 | 13,590 | -3,356 | 0.01 | 0.01 | -0.00 | sell |
| Ghisallo Capital Management LLC | 13,800 | 0 | -13,800 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 36,558 | 0 | -36,558 | 0.00 | 0.00 | -0.00 | sell |
| AJU IB Investment Co., Ltd. | 47,695 | 0 | -47,695 | 1.31 | 0.00 | -1.31 | sell |
| Caligan Partners LP | 112,128 | 0 | -112,128 | 0.07 | 0.00 | -0.07 | sell |