| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RENAISSANCE TECHNOLOGIES LLC | 20,700 | 209,700 | +189,000 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 83,373 | +83,373 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 110,481 | 155,481 | +45,000 | 0.01 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 30,351 | +30,351 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 890,353 | 902,531 | +12,178 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 10,763 | +10,763 | 0.00 | 0.00 | +0.00 | buy |
| Dunhill Financial, LLC | 0 | 10,274 | +10,274 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 3,882 | 13,975 | +10,093 | 0.00 | 0.00 | -0.00 | buy |
| Artal Group S.A. | 450,000 | 450,000 | 0 | 0.04 | 0.01 | -0.03 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 84,826 | 84,826 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Trustees of Columbia University in the City of New York | 249,635 | 249,635 | 0 | 0.97 | 0.29 | -0.68 | hold |
| Rock Springs Capital Management LP | 1,440,759 | 1,440,759 | 0 | 0.08 | 0.02 | -0.06 | hold |
| Bain Capital Life Sciences Investors, LLC | 2,805,413 | 2,805,413 | 0 | 0.66 | 0.15 | -0.51 | hold |
| Qube Research & Technologies Ltd | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Key FInancial Inc | 830 | 830 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Atlas Venture Life Science Advisors, LLC | 2,759,344 | 2,759,344 | 0 | 0.90 | 0.18 | -0.72 | hold |
| FMR LLC | 1,907,671 | 1,907,671 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIL Ltd | 218,705 | 218,705 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CULLEN/FROST BANKERS, INC. | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 17,798 | 17,798 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11,925 | 11,925 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 15,690 | 15,690 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Laurion Capital Management LP | 139,260 | 116,847 | -22,413 | 0.01 | 0.00 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 26,449 | 0 | -26,449 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 226,719 | 0 | -226,719 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 226,941 | 0 | -226,941 | 0.05 | 0.00 | -0.05 | sell |
| HARVARD MANAGEMENT CO INC | 416,059 | 0 | -416,059 | 0.10 | 0.00 | -0.10 | sell |
| Octagon Capital Advisors LP | 2,318,500 | 1,785,000 | -533,500 | 0.86 | 0.16 | -0.70 | sell |