| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,355,867 | 5,355,867 | 0 | 0.01 | 0.01 | -0.00 | hold |
| STATE STREET CORP | 1,350,948 | 4,485,615 | +3,134,667 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 3,570,872 | 3,570,872 | 0 | 2.48 | 2.35 | -0.13 | hold |
| Laurion Capital Management LP | 2,736,367 | 2,720,983 | -15,384 | 1.42 | 1.13 | -0.29 | sell |
| BAKER BROS. ADVISORS LP | 2,108,949 | 2,108,949 | 0 | 0.35 | 0.40 | +0.05 | hold |
| VANGUARD GROUP INC | 1,349,999 | 1,365,625 | +15,626 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,718,245 | 1,285,278 | -432,967 | 0.01 | 0.01 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,182,741 | 1,193,953 | +11,212 | 0.21 | 0.18 | -0.03 | buy |
| Aisling Capital Management LP | 798,757 | 798,757 | 0 | 3.46 | 4.04 | +0.58 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 480,322 | 493,631 | +13,309 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 101,679 | 478,367 | +376,688 | 0.01 | 0.03 | +0.02 | buy |
| Woodline Partners LP | 464,573 | 464,573 | 0 | 0.07 | 0.06 | -0.01 | hold |
| MORGAN STANLEY | 478,402 | 457,421 | -20,981 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 53,193 | 409,558 | +356,365 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 171,888 | 347,964 | +176,076 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 109,691 | 305,953 | +196,262 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 86,445 | 287,864 | +201,419 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 73,312 | 264,199 | +190,887 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 222,372 | 216,444 | -5,928 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 181,147 | 181,147 | 0 | 0.06 | 0.07 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 176,797 | 178,935 | +2,138 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 176,574 | 177,602 | +1,028 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 171,430 | 171,763 | +333 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 85,536 | 102,534 | +16,998 | 0.00 | 0.00 | +0.00 | buy |
| Sculptor Capital LP | 0 | 95,100 | +95,100 | 0.00 | 0.03 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 89,865 | 89,865 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 76,285 | 76,285 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Prosight Management, LP | 42,991 | 75,000 | +32,009 | 0.25 | 0.31 | +0.06 | buy |
| PROFUND ADVISORS LLC | 16,527 | 72,877 | +56,350 | 0.01 | 0.04 | +0.03 | buy |
| Bank of New York Mellon Corp | 71,265 | 63,917 | -7,348 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 156,067 | 59,787 | -96,280 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 32,101 | 54,469 | +22,368 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 53,546 | +53,546 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 0 | 47,279 | +47,279 | 0.00 | 0.14 | +0.14 | buy |
| BARCLAYS PLC | 72,268 | 46,817 | -25,451 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 45,700 | 45,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARSHALL WACE, LLP | 239,539 | 42,572 | -196,967 | 0.01 | 0.00 | -0.01 | sell |
| Nan Fung Group Holdings Ltd | 40,000 | 40,000 | 0 | 0.36 | 0.55 | +0.19 | hold |
| GRIFFIN ASSET MANAGEMENT, INC. | 27,190 | 37,890 | +10,700 | 0.05 | 0.07 | +0.02 | buy |
| JANE STREET GROUP, LLC | 316,712 | 36,218 | -280,494 | 0.01 | 0.00 | -0.00 | sell |
| Artia Global Partners LP | 25,452 | 35,452 | +10,000 | 0.15 | 0.13 | -0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 53,194 | 35,444 | -17,750 | 0.06 | 0.04 | -0.02 | sell |
| TWO SIGMA INVESTMENTS, LP | 138,238 | 33,401 | -104,837 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 0 | 30,924 | +30,924 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 36,294 | 30,748 | -5,546 | 0.00 | 0.00 | -0.00 | sell |
| AFG FIDUCIARY SERVICES LIMITED PARTNERSHIP | 0 | 29,177 | +29,177 | 0.00 | 0.28 | +0.28 | buy |
| ALLIANCEBERNSTEIN L.P. | 29,140 | 29,140 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 27,358 | 27,966 | +608 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 22,428 | 27,124 | +4,696 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 27,041 | +27,041 | 0.00 | 0.04 | +0.04 | buy |
| ALPS ADVISORS INC | 30,399 | 25,188 | -5,211 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 27,246 | 23,799 | -3,447 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 0 | 23,027 | +23,027 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,902 | 22,860 | -1,042 | 0.00 | 0.00 | -0.00 | sell |
| E Fund Management Co., Ltd. | 0 | 22,605 | +22,605 | 0.00 | 0.02 | +0.02 | buy |
| TRANSCEND CAPITAL ADVISORS, LLC | 22,700 | 22,000 | -700 | 0.03 | 0.03 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 0 | 21,000 | +21,000 | 0.00 | 0.07 | +0.07 | buy |
| Legal & General Group Plc | 19,902 | 19,986 | +84 | 0.00 | 0.00 | -0.00 | buy |
| NATIXIS | 11,800 | 19,500 | +7,700 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 25,000 | 17,800 | -7,200 | 0.01 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 17,366 | +17,366 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 19,086 | 17,040 | -2,046 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 9,248 | 16,920 | +7,672 | 0.00 | 0.01 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 13,801 | 15,513 | +1,712 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 25,362 | 13,704 | -11,658 | 0.01 | 0.00 | -0.00 | sell |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 12,197 | +12,197 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 0 | 11,888 | +11,888 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 30,779 | 11,680 | -19,099 | 0.01 | 0.00 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 11,600 | 11,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 10,646 | 10,646 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Invesco Ltd. | 10,262 | 10,465 | +203 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 9,875 | 9,791 | -84 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,177 | 8,158 | -19 | 0.00 | 0.00 | -0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 8,000 | 8,008 | +8 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 4,131 | 6,862 | +2,731 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 6,589 | 6,166 | -423 | 0.06 | 0.05 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 5,177 | 5,974 | +797 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,744 | 4,744 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROYAL BANK OF CANADA | 8,324 | 4,258 | -4,066 | 0.00 | 0.00 | -0.00 | sell |
| Grove Bank & Trust | 3,863 | 3,863 | 0 | 0.01 | 0.01 | -0.00 | hold |
| OSAIC HOLDINGS, INC. | 3,857 | 3,860 | +3 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 2,500 | 2,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EntryPoint Capital, LLC | 10,699 | 2,444 | -8,255 | 0.15 | 0.03 | -0.12 | sell |
| Pacer Advisors, Inc. | 0 | 2,254 | +2,254 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,641 | 1,641 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 1,400 | 1,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allspring Global Investments Holdings, LLC | 915 | 1,158 | +243 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 5,420 | 1,110 | -4,310 | 0.02 | 0.00 | -0.01 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,486 | 1,098 | -388 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 750 | 750 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 2,813 | 670 | -2,143 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 15,825 | 443 | -15,382 | 0.00 | 0.00 | -0.00 | sell |
| Glen Eagle Advisors, LLC | 250 | 250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 109 | 109 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 36 | +36 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 52,994 | 0 | -52,994 | 0.00 | 0.00 | -0.00 | sell |