| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,355,867 | 5,391,566 | +35,699 | 0.01 | 0.00 | -0.00 | buy |
| Cormorant Asset Management, LP | 3,570,872 | 3,570,872 | 0 | 2.35 | 0.93 | -1.42 | hold |
| BAKER BROS. ADVISORS LP | 2,108,949 | 2,108,949 | 0 | 0.40 | 0.12 | -0.27 | hold |
| VANGUARD GROUP INC | 1,365,625 | 1,390,756 | +25,131 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,100,000 | +1,100,000 | 0.00 | 0.01 | +0.01 | buy |
| Aisling Capital Management LP | 798,757 | 798,757 | 0 | 4.04 | 1.56 | -2.49 | hold |
| STATE STREET CORP | 4,485,615 | 675,737 | -3,809,878 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 493,631 | 597,188 | +103,557 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 457,421 | 466,945 | +9,524 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 33,401 | 330,674 | +297,273 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 329,106 | +329,106 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 267,818 | +267,818 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 464,573 | 236,419 | -228,154 | 0.06 | 0.01 | -0.05 | sell |
| NORTHERN TRUST CORP | 216,444 | 211,952 | -4,492 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 178,935 | 200,840 | +21,905 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 181,147 | 181,147 | 0 | 0.07 | 0.02 | -0.04 | hold |
| DEUTSCHE BANK AG\ | 171,763 | 178,207 | +6,444 | 0.00 | 0.00 | -0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 167,110 | +167,110 | 0.00 | 0.95 | +0.95 | buy |
| GSA CAPITAL PARTNERS LLP | 35,444 | 155,571 | +120,127 | 0.04 | 0.05 | +0.01 | buy |
| Marex Group plc | 0 | 150,000 | +150,000 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 36,218 | 134,894 | +98,676 | 0.00 | 0.00 | -0.00 | buy |
| Prosight Management, LP | 75,000 | 124,377 | +49,377 | 0.31 | 0.17 | -0.14 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 102,534 | 118,463 | +15,929 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 305,953 | 116,415 | -189,538 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 0 | 110,700 | +110,700 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 47,279 | 102,717 | +55,438 | 0.14 | 0.12 | -0.03 | buy |
| GOLDMAN SACHS GROUP INC | 347,964 | 98,563 | -249,401 | 0.00 | 0.00 | -0.00 | sell |
| Sculptor Capital LP | 95,100 | 95,100 | 0 | 0.03 | 0.01 | -0.02 | hold |
| Bank of New York Mellon Corp | 63,917 | 93,317 | +29,400 | 0.00 | 0.00 | -0.00 | buy |
| OPPENHEIMER & CO INC | 13,704 | 91,522 | +77,818 | 0.00 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 89,865 | 89,857 | -8 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 2,720,983 | 88,401 | -2,632,582 | 1.13 | 0.01 | -1.12 | sell |
| ALLIANCEBERNSTEIN L.P. | 29,140 | 82,540 | +53,400 | 0.00 | 0.00 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 76,285 | 76,285 | 0 | 0.01 | 0.00 | -0.01 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 287,864 | 67,519 | -220,345 | 0.01 | 0.00 | -0.01 | sell |
| SG Americas Securities, LLC | 30,924 | 59,009 | +28,085 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 52,628 | +52,628 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 59,787 | 50,016 | -9,771 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 45,700 | 49,500 | +3,800 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 264,199 | 48,007 | -216,192 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 0 | 45,929 | +45,929 | 0.00 | 0.02 | +0.02 | buy |
| Nan Fung Group Holdings Ltd | 40,000 | 40,000 | 0 | 0.55 | 0.19 | -0.36 | hold |
| GRIFFIN ASSET MANAGEMENT, INC. | 37,890 | 38,890 | +1,000 | 0.07 | 0.02 | -0.05 | buy |
| MARSHALL WACE, LLP | 42,572 | 38,672 | -3,900 | 0.00 | 0.00 | -0.00 | sell |
| iA Global Asset Management Inc. | 0 | 38,610 | +38,610 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 27,966 | 36,238 | +8,272 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 11,600 | 35,429 | +23,829 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 34,845 | +34,845 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 31,379 | +31,379 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 19,986 | 26,840 | +6,854 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,860 | 25,063 | +2,203 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 443 | 24,392 | +23,949 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 24,305 | +24,305 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 54,469 | 24,094 | -30,375 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 22,274 | +22,274 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 409,558 | 21,424 | -388,134 | 0.01 | 0.00 | -0.01 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 8,008 | 21,000 | +12,992 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 10,646 | 17,037 | +6,391 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 17,040 | 16,615 | -425 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 27,124 | 15,699 | -11,425 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 0 | 15,543 | +15,543 | 0.00 | 0.04 | +0.04 | buy |
| BARCLAYS PLC | 46,817 | 15,458 | -31,359 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 177,602 | 14,537 | -163,065 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 0 | 13,200 | +13,200 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 16,920 | 12,906 | -4,014 | 0.01 | 0.00 | -0.01 | sell |
| DRW Securities, LLC | 0 | 12,203 | +12,203 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 10,465 | 11,693 | +1,228 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,285,278 | 11,200 | -1,274,078 | 0.01 | 0.00 | -0.01 | sell |
| Jump Financial, LLC | 11,680 | 10,800 | -880 | 0.00 | 0.00 | -0.00 | sell |
| Parallax Volatility Advisers, L.P. | 0 | 10,455 | +10,455 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 10,321 | +10,321 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 10,070 | +10,070 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 21,000 | 10,000 | -11,000 | 0.07 | 0.01 | -0.07 | sell |
| High Net Worth Advisory Group LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,158 | 8,178 | +20 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 8,075 | +8,075 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Trading LLC | 11,888 | 6,243 | -5,645 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 0 | 4,782 | +4,782 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,744 | 4,744 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 6,862 | 4,223 | -2,639 | 0.01 | 0.00 | -0.01 | sell |
| Grove Bank & Trust | 3,863 | 3,863 | 0 | 0.01 | 0.00 | -0.01 | hold |
| AlphaQuest LLC | 1,110 | 3,112 | +2,002 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 2,500 | 2,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 1,641 | 1,641 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 15,513 | 1,073 | -14,440 | 0.00 | 0.00 | -0.00 | sell |
| Global Retirement Partners, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 750 | 750 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aquatic Capital Management LLC | 0 | 700 | +700 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 670 | 670 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Glen Eagle Advisors, LLC | 250 | 250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 109 | 109 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allspring Global Investments Holdings, LLC | 1,158 | 34 | -1,124 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 15 | 33 | +18 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 19 | +19 | 0.00 | 0.00 | 0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 4,258 | 0 | -4,258 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 72,877 | 0 | -72,877 | 0.04 | 0.00 | -0.04 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 36 | 0 | -36 | 0.00 | 0.00 | -0.00 | sell |