| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,391,566 | 5,431,525 | +39,959 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 3,570,872 | 3,570,872 | 0 | 0.93 | 1.91 | +0.98 | hold |
| BAKER BROS. ADVISORS LP | 2,108,949 | 2,108,949 | 0 | 0.12 | 0.22 | +0.10 | hold |
| VANGUARD GROUP INC | 1,390,756 | 1,397,897 | +7,141 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 50,016 | 1,378,408 | +1,328,392 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,100,000 | 900,000 | -200,000 | 0.01 | 0.02 | +0.01 | sell |
| Aisling Capital Management LP | 798,757 | 798,757 | 0 | 1.56 | 3.09 | +1.53 | hold |
| STATE STREET CORP | 675,737 | 641,195 | -34,542 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 597,188 | 601,479 | +4,291 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 466,945 | 506,811 | +39,866 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 211,952 | 310,440 | +98,488 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 330,674 | 273,881 | -56,793 | 0.00 | 0.01 | +0.00 | sell |
| MARSHALL WACE, LLP | 38,672 | 244,725 | +206,053 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 236,419 | 241,107 | +4,688 | 0.01 | 0.02 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 200,840 | 208,391 | +7,551 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 181,147 | 181,147 | 0 | 0.02 | 0.06 | +0.03 | hold |
| DEUTSCHE BANK AG\ | 178,207 | 179,287 | +1,080 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 150,000 | 150,000 | 0 | 0.02 | 0.03 | +0.02 | hold |
| JANE STREET GROUP, LLC | 134,894 | 149,895 | +15,001 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 102,717 | 130,336 | +27,619 | 0.12 | 0.31 | +0.20 | buy |
| TWO SIGMA ADVISERS, LP | 110,700 | 117,600 | +6,900 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 98,563 | 102,037 | +3,474 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 155,571 | 98,291 | -57,280 | 0.05 | 0.07 | +0.03 | sell |
| GRIFFIN ASSET MANAGEMENT, INC. | 38,890 | 96,070 | +57,180 | 0.02 | 0.11 | +0.09 | buy |
| Sculptor Capital LP | 95,100 | 95,100 | 0 | 0.01 | 0.02 | +0.01 | hold |
| OPPENHEIMER & CO INC | 91,522 | 87,569 | -3,953 | 0.01 | 0.01 | +0.01 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 167,110 | 83,554 | -83,556 | 0.95 | 0.75 | -0.19 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 329,106 | 82,300 | -246,806 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 76,285 | 76,285 | 0 | 0.00 | 0.01 | +0.01 | hold |
| Bank of New York Mellon Corp | 93,317 | 75,522 | -17,795 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 82,540 | 70,230 | -12,310 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 89,857 | 64,657 | -25,200 | 0.00 | 0.00 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 58,300 | +58,300 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 15,699 | 40,477 | +24,778 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 15,458 | 39,620 | +24,162 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 36,238 | 35,892 | -346 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 48,007 | 34,303 | -13,704 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 0 | 32,873 | +32,873 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 67,519 | 22,323 | -45,196 | 0.00 | 0.00 | -0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 21,000 | 21,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 12,906 | 20,985 | +8,079 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 21,424 | 20,606 | -818 | 0.00 | 0.00 | +0.00 | sell |
| AlphaQuest LLC | 3,112 | 19,553 | +16,441 | 0.00 | 0.02 | +0.02 | buy |
| LPL Financial LLC | 24,094 | 19,094 | -5,000 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14,537 | 18,137 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 17,838 | +17,838 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 17,667 | +17,667 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 17,037 | 16,701 | -336 | 0.00 | 0.00 | +0.00 | sell |
| Brevan Howard Capital Management LP | 31,379 | 16,302 | -15,077 | 0.01 | 0.01 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,762 | 15,145 | +5,383 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 14,868 | 14,777 | -91 | 0.00 | 0.00 | +0.00 | sell |
| Creative Planning | 12,000 | 12,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WOLVERINE TRADING, LLC | 0 | 11,629 | +11,629 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 11,693 | 11,191 | -502 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 11,017 | +11,017 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 10,000 | 10,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Parallax Volatility Advisers, L.P. | 10,455 | 10,000 | -455 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 0 | 8,515 | +8,515 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,178 | 8,178 | 0 | 0.00 | 0.00 | +0.00 | hold |
| China Universal Asset Management Co., Ltd. | 4,223 | 6,964 | +2,741 | 0.00 | 0.01 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 0 | 3,866 | +3,866 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 26,840 | 3,392 | -23,448 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,641 | 2,800 | +1,159 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 24,392 | 2,635 | -21,757 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 2,500 | 2,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FNY Investment Advisers, LLC | 0 | 2,025 | +2,025 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,063 | 2,002 | -23,061 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 1,073 | 1,310 | +237 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 34 | 1,036 | +1,002 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IFP Advisors, Inc | 750 | 750 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 670 | 670 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PICTON MAHONEY ASSET MANAGEMENT | 0 | 397 | +397 | 0.00 | 0.00 | +0.00 | buy |
| Glen Eagle Advisors, LLC | 250 | 250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GAMMA Investing LLC | 0 | 183 | +183 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 152 | +152 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 125 | +125 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 109 | 109 | 0 | 0.00 | 0.00 | +0.00 | hold |
| nVerses Capital, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 19 | 94 | +75 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 33 | 73 | +40 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 13,200 | 0 | -13,200 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 22,274 | 0 | -22,274 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 11,200 | 0 | -11,200 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 59,009 | 0 | -59,009 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,744 | 0 | -4,744 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Trading LLC | 6,243 | 0 | -6,243 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 88,401 | 0 | -88,401 | 0.01 | 0.00 | -0.01 | sell |
| HRT FINANCIAL LP | 34,845 | 0 | -34,845 | 0.00 | 0.00 | -0.00 | sell |
| DRW Securities, LLC | 12,203 | 0 | -12,203 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 10,070 | 0 | -10,070 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 49,500 | 0 | -49,500 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 24,305 | 0 | -24,305 | 0.00 | 0.00 | -0.00 | sell |
| Prosight Management, LP | 124,377 | 0 | -124,377 | 0.17 | 0.00 | -0.17 | sell |
| Squarepoint Ops LLC | 52,628 | 0 | -52,628 | 0.00 | 0.00 | -0.00 | sell |
| Grove Bank & Trust | 3,863 | 0 | -3,863 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 8,075 | 0 | -8,075 | 0.01 | 0.00 | -0.01 | sell |
| Walleye Capital LLC | 267,818 | 0 | -267,818 | 0.01 | 0.00 | -0.01 | sell |