| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 912,866 | 1,182,741 | +269,875 | 0.16 | 0.21 | +0.04 | buy |
| JANE STREET GROUP, LLC | 64,335 | 316,712 | +252,377 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 231,465 | 478,402 | +246,937 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 239,539 | +239,539 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 11,174 | 171,430 | +160,256 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 156,067 | +156,067 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 2,613,135 | 2,736,367 | +123,232 | 0.94 | 1.42 | +0.48 | buy |
| Woodline Partners LP | 341,673 | 464,573 | +122,900 | 0.06 | 0.07 | +0.02 | buy |
| HRT FINANCIAL LP | 0 | 90,756 | +90,756 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 85,536 | +85,536 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 95,849 | 171,888 | +76,039 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 44,061 | 110,377 | +66,316 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 32,154 | 86,445 | +54,291 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 52,994 | +52,994 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 42,950 | +42,950 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 185,155 | 222,372 | +37,217 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 36,294 | +36,294 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 142,436 | 176,574 | +34,138 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 32,101 | +32,101 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 30,399 | +30,399 | 0.00 | 0.00 | +0.00 | buy |
| GRIFFIN ASSET MANAGEMENT, INC. | 0 | 27,190 | +27,190 | 0.00 | 0.05 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 453,241 | 480,322 | +27,081 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 26,817 | +26,817 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 0 | 25,362 | +25,362 | 0.00 | 0.01 | +0.01 | buy |
| Bellevue Group AG | 0 | 25,000 | +25,000 | 0.00 | 0.01 | +0.01 | buy |
| TRANSCEND CAPITAL ADVISORS, LLC | 0 | 22,700 | +22,700 | 0.00 | 0.03 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 22,428 | +22,428 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 55,800 | 73,312 | +17,512 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Middle East FZE | 0 | 15,792 | +15,792 | 0.00 | 0.02 | +0.02 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 13,356 | +13,356 | 0.00 | 0.03 | +0.03 | buy |
| Tower Research Capital LLC (TRC) | 3,251 | 15,825 | +12,574 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 41,048 | 53,194 | +12,146 | 0.05 | 0.06 | +0.02 | buy |
| NATIXIS | 0 | 11,800 | +11,800 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 5,344,191 | 5,355,867 | +11,676 | 0.01 | 0.01 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 11,206 | +11,206 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,339,428 | 1,349,999 | +10,571 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 8,324 | +8,324 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 8,000 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| CENTAURUS FINANCIAL, INC. | 0 | 7,014 | +7,014 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 25,080 | 29,140 | +4,060 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,543 | 6,589 | +4,046 | 0.02 | 0.06 | +0.04 | buy |
| Grove Bank & Trust | 0 | 3,863 | +3,863 | 0.00 | 0.01 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 0 | 3,857 | +3,857 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 921 | 4,131 | +3,210 | 0.00 | 0.01 | +0.01 | buy |
| SIGNATUREFD, LLC | 0 | 2,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 174,428 | 176,797 | +2,369 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 6,903 | 9,248 | +2,345 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 1,400 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 70,336 | 71,265 | +929 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 0 | 750 | +750 | 0.00 | 0.00 | +0.00 | buy |
| Glen Eagle Advisors, LLC | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,641 | 1,641 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 2,108,949 | 2,108,949 | 0 | 0.17 | 0.35 | +0.18 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,744 | 4,744 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 109 | 109 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ArrowMark Colorado Holdings LLC | 76,285 | 76,285 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MetLife Investment Management, LLC | 10,646 | 10,646 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Gradient Investments LLC | 116 | 116 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cormorant Asset Management, LP | 3,570,872 | 3,570,872 | 0 | 2.87 | 2.48 | -0.38 | hold |
| Rock Springs Capital Management LP | 181,147 | 181,147 | 0 | 0.07 | 0.06 | -0.00 | hold |
| Cresset Asset Management, LLC | 12,500 | 12,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aisling Capital Management LP | 798,757 | 798,757 | 0 | 4.53 | 3.46 | -1.07 | hold |
| Nan Fung Group Holdings Ltd | 40,000 | 40,000 | 0 | 0.45 | 0.36 | -0.08 | hold |
| Artia Global Partners LP | 25,452 | 25,452 | 0 | 0.15 | 0.15 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 89,865 | 89,865 | 0 | 0.00 | 0.00 | -0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,486 | 1,486 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 19,902 | 19,902 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 11,600 | 11,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,216 | 8,177 | -39 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 9,915 | 9,875 | -40 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 27,443 | 27,358 | -85 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 129 | 0 | -129 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 3,012 | 2,813 | -199 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 1,133 | 915 | -218 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24,724 | 23,902 | -822 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 21,562 | 19,086 | -2,476 | 0.00 | 0.00 | -0.00 | sell |
| Sandia Investment Management LP | 6,200 | 3,715 | -2,485 | 0.02 | 0.04 | +0.01 | sell |
| Mirae Asset Global Investments Co., Ltd. | 17,804 | 13,801 | -4,003 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 50,100 | 45,700 | -4,400 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 6,001 | 0 | -6,001 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 18,024 | 10,262 | -7,762 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 10,622 | 0 | -10,622 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 11,064 | 0 | -11,064 | 0.08 | 0.00 | -0.08 | sell |
| Jump Financial, LLC | 42,716 | 30,779 | -11,937 | 0.02 | 0.01 | -0.01 | sell |
| E Fund Management Co., Ltd. | 12,010 | 0 | -12,010 | 0.01 | 0.00 | -0.01 | sell |
| Ghisallo Capital Management LLC | 20,000 | 0 | -20,000 | 0.03 | 0.00 | -0.03 | sell |
| PROFUND ADVISORS LLC | 38,890 | 16,527 | -22,363 | 0.03 | 0.01 | -0.02 | sell |
| Trexquant Investment LP | 31,573 | 0 | -31,573 | 0.01 | 0.00 | -0.01 | sell |
| Cubist Systematic Strategies, LLC | 91,595 | 54,791 | -36,804 | 0.02 | 0.01 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 39,935 | 0 | -39,935 | 0.40 | 0.00 | -0.40 | sell |
| DekaBank Deutsche Girozentrale | 40,000 | 0 | -40,000 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 46,531 | 5,177 | -41,354 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 116,621 | 72,268 | -44,353 | 0.00 | 0.00 | -0.00 | sell |
| Prosight Management, LP | 94,817 | 42,991 | -51,826 | 0.41 | 0.25 | -0.16 | sell |
| CITIGROUP INC | 116,134 | 53,193 | -62,941 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 78,811 | 0 | -78,811 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 150,387 | 27,246 | -123,141 | 0.00 | 0.00 | -0.00 | sell |