| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 0 | 2,603,682 | +2,603,682 | 0.00 | 0.05 | +0.05 | buy |
| BRAIDWELL LP | 0 | 1,140,040 | +1,140,040 | 0.00 | 1.26 | +1.26 | buy |
| BlackRock, Inc. | 2,570,425 | 3,502,841 | +932,416 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 58,446 | 964,011 | +905,565 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 373,000 | 1,107,814 | +734,814 | 0.07 | 0.19 | +0.13 | buy |
| Logos Global Management LP | 1,235,000 | 1,935,000 | +700,000 | 1.90 | 2.49 | +0.59 | buy |
| MARSHALL WACE, LLP | 310,639 | 914,572 | +603,933 | 0.01 | 0.02 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 4,567,274 | 5,032,915 | +465,641 | 3.51 | 3.27 | -0.24 | buy |
| STATE STREET CORP | 636,722 | 997,533 | +360,811 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 636,162 | 954,886 | +318,724 | 0.14 | 0.17 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 50,095 | 339,276 | +289,181 | 0.09 | 0.48 | +0.39 | buy |
| Hudson Bay Capital Management LP | 8,150 | 270,000 | +261,850 | 0.00 | 0.04 | +0.04 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 260,566 | +260,566 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 599,967 | 858,054 | +258,087 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 3,477,562 | 3,732,569 | +255,007 | 2.14 | 1.64 | -0.50 | buy |
| RTW INVESTMENTS, LP | 0 | 212,000 | +212,000 | 0.00 | 0.05 | +0.05 | buy |
| FMR LLC | 864,214 | 1,056,959 | +192,745 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 227,343 | 417,564 | +190,221 | 1.17 | 1.78 | +0.62 | buy |
| ExodusPoint Capital Management, LP | 0 | 183,264 | +183,264 | 0.00 | 0.05 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 15,845 | 192,952 | +177,107 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 37,181 | 199,872 | +162,691 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 226,227 | 383,773 | +157,546 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 195,084 | 321,227 | +126,143 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 107,486 | 227,425 | +119,939 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 27,945 | 128,006 | +100,061 | 0.01 | 0.02 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 93,357 | +93,357 | 0.00 | 0.03 | +0.03 | buy |
| SummitTX Capital, L.P. | 83,750 | 176,291 | +92,541 | 0.08 | 0.14 | +0.06 | buy |
| Woodline Partners LP | 650,229 | 736,216 | +85,987 | 0.07 | 0.07 | -0.01 | buy |
| Casdin Capital, LLC | 758,857 | 843,857 | +85,000 | 1.72 | 1.26 | -0.45 | buy |
| NORTHERN TRUST CORP | 211,382 | 294,742 | +83,360 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 81,668 | +81,668 | 0.00 | 0.02 | +0.02 | buy |
| CITADEL ADVISORS LLC | 775,714 | 852,676 | +76,962 | 0.02 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 186,433 | 260,566 | +74,133 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,475 | 77,251 | +70,776 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 65,468 | +65,468 | 0.00 | 0.01 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 9,420 | 74,384 | +64,964 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 26,854 | 75,317 | +48,463 | 0.01 | 0.03 | +0.02 | buy |
| Jump Financial, LLC | 0 | 47,129 | +47,129 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 0 | 47,100 | +47,100 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 99,850 | 136,572 | +36,722 | 0.82 | 0.93 | +0.11 | buy |
| Quadrature Capital Ltd | 0 | 30,047 | +30,047 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 35,000 | 65,000 | +30,000 | 0.24 | 0.37 | +0.13 | buy |
| Exome Asset Management LLC | 88,510 | 114,692 | +26,182 | 1.55 | 2.11 | +0.56 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,435 | 26,063 | +24,628 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 23,840 | +23,840 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 74,268 | 97,588 | +23,320 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 22,174 | +22,174 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 60,587 | 82,724 | +22,137 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 8,563 | 30,265 | +21,702 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,369 | 32,047 | +21,678 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 25,485 | 46,227 | +20,742 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 59,637 | 80,216 | +20,579 | 0.00 | 0.00 | +0.00 | buy |
| Jackson Creek Investment Advisors LLC | 0 | 18,345 | +18,345 | 0.00 | 0.16 | +0.16 | buy |
| OSAIC HOLDINGS, INC. | 59,943 | 77,850 | +17,907 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 427 | 17,739 | +17,312 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 39,171 | 55,970 | +16,799 | 0.01 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 63,360 | 78,468 | +15,108 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 20,263 | 34,993 | +14,730 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 9,262 | 23,733 | +14,471 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 279,713 | 293,144 | +13,431 | 0.00 | 0.00 | -0.00 | buy |
| Jain Global LLC | 0 | 12,238 | +12,238 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 31,513 | 42,873 | +11,360 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 0 | 11,327 | +11,327 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 0 | 11,025 | +11,025 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 122,695 | 132,870 | +10,175 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 5,790 | 15,781 | +9,991 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 9,814 | +9,814 | 0.00 | 0.07 | +0.07 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 9,100 | +9,100 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 7,095 | 15,193 | +8,098 | 0.03 | 0.05 | +0.02 | buy |
| Rafferty Asset Management, LLC | 0 | 8,077 | +8,077 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 8,072 | +8,072 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 7,592 | +7,592 | 0.00 | 0.00 | +0.00 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | 7,465 | +7,465 | 0.00 | 0.07 | +0.07 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 6,975 | +6,975 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 7,016 | 13,605 | +6,589 | 0.06 | 0.09 | +0.04 | buy |
| MetLife Investment Management, LLC | 14,542 | 20,899 | +6,357 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 13,612 | 19,434 | +5,822 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 5,300 | +5,300 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,200 | 12,400 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12,416 | 16,248 | +3,832 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 7,101 | 10,407 | +3,306 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 2,672 | +2,672 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 2,052 | +2,052 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,570 | 16,402 | +1,832 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,995 | 13,808 | +1,813 | 0.03 | 0.02 | -0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 1,600 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,165 | 3,202 | +1,037 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 813 | +813 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 574 | +574 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 361 | 655 | +294 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 221 | +221 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 165 | +165 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 154 | +154 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 9 | 80 | +71 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 3 | 12 | +9 | 0.00 | 0.00 | 0.00 | buy |
| Global Retirement Partners, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 481,790 | 481,790 | 0 | 0.02 | 0.02 | -0.00 | hold |
| ARCH Venture Management, LLC | 4,120,053 | 4,120,053 | 0 | 18.16 | 11.18 | -6.99 | hold |