| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TRV GP IV, LLC | 0 | 6,073,958 | +6,073,958 | 0.00 | 72.02 | +72.02 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 4,129,001 | +4,129,001 | 0.00 | 2.08 | +2.08 | buy |
| ARCH Venture Management, LLC | 0 | 4,120,053 | +4,120,053 | 0.00 | 22.00 | +22.00 | buy |
| Deep Track Capital, LP | 0 | 3,269,126 | +3,269,126 | 0.00 | 1.17 | +1.17 | buy |
| Matrix Capital Management Company, LP | 0 | 2,486,184 | +2,486,184 | 0.00 | 7.88 | +7.88 | buy |
| Alphabet Inc. | 0 | 2,412,471 | +2,412,471 | 0.00 | 1.68 | +1.68 | buy |
| Foresite Capital Management IV, LLC | 0 | 2,111,919 | +2,111,919 | 0.00 | 20.93 | +20.93 | buy |
| AH Capital Management, L.L.C. | 0 | 1,702,225 | +1,702,225 | 0.00 | 2.67 | +2.67 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 1,246,370 | +1,246,370 | 0.00 | 0.01 | +0.01 | buy |
| General Catalyst Group Management, LLC | 0 | 1,035,910 | +1,035,910 | 0.00 | 1.29 | +1.29 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 1,016,446 | +1,016,446 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 968,383 | +968,383 | 0.00 | 0.00 | +0.00 | buy |
| TRV GP V, LLC | 0 | 950,800 | +950,800 | 0.00 | 8.37 | +8.37 | buy |
| Casdin Capital, LLC | 0 | 946,357 | +946,357 | 0.00 | 0.85 | +0.85 | buy |
| Logos Global Management LP | 0 | 936,914 | +936,914 | 0.00 | 1.83 | +1.83 | buy |
| Woodline Partners LP | 0 | 929,102 | +929,102 | 0.00 | 0.07 | +0.07 | buy |
| VANGUARD GROUP INC | 0 | 666,554 | +666,554 | 0.00 | 0.00 | +0.00 | buy |
| HARVARD MANAGEMENT CO INC | 0 | 637,528 | +637,528 | 0.00 | 0.62 | +0.62 | buy |
| BlackRock, Inc. | 0 | 582,588 | +582,588 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 481,790 | +481,790 | 0.00 | 0.01 | +0.01 | buy |
| Octagon Capital Advisors LP | 0 | 468,000 | +468,000 | 0.00 | 0.70 | +0.70 | buy |
| HHLR ADVISORS, LTD. | 0 | 457,535 | +457,535 | 0.00 | 0.14 | +0.14 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 355,554 | +355,554 | 0.00 | 0.97 | +0.97 | buy |
| Foresite Capital Management V, LLC | 0 | 345,191 | +345,191 | 0.00 | 4.34 | +4.34 | buy |
| Ikarian Capital, LLC | 0 | 322,740 | +322,740 | 0.00 | 1.16 | +1.16 | buy |
| Affinity Asset Advisors, LLC | 0 | 250,000 | +250,000 | 0.00 | 0.43 | +0.43 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 212,464 | +212,464 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 132,115 | +132,115 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 0 | 125,000 | +125,000 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 96,968 | +96,968 | 0.00 | 0.04 | +0.04 | buy |
| UBS Group AG | 0 | 88,064 | +88,064 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 72,305 | +72,305 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 70,838 | +70,838 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 64,713 | +64,713 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 30,000 | +30,000 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 0 | 20,552 | +20,552 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 19,597 | +19,597 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 17,233 | +17,233 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 17,000 | +17,000 | 0.00 | 0.09 | +0.09 | buy |
| BARCLAYS PLC | 0 | 14,644 | +14,644 | 0.00 | 0.00 | +0.00 | buy |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 0 | 13,670 | +13,670 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 13,129 | +13,129 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 10,141 | +10,141 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 8,885 | +8,885 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 7,235 | +7,235 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 6,216 | +6,216 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 5,135 | +5,135 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 4,693 | +4,693 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 0 | 4,328 | +4,328 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 2,300 | +2,300 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 2,241 | +2,241 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 1,600 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 894 | +894 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 871 | +871 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 834 | +834 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 636 | +636 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 554 | +554 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 305 | +305 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 74 | +74 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |