| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 4,567,274 | 4,567,274 | 0 | 5.08 | 3.51 | -1.57 | hold |
| TRV GP IV, LLC | 4,473,958 | 4,473,958 | 0 | 72.65 | 50.04 | -22.62 | hold |
| ARCH Venture Management, LLC | 4,120,053 | 4,120,053 | 0 | 26.19 | 18.16 | -8.03 | hold |
| Deep Track Capital, LP | 4,246,440 | 3,477,562 | -768,878 | 4.01 | 2.14 | -1.87 | sell |
| JANUS HENDERSON GROUP PLC | 3,142,587 | 2,858,876 | -283,711 | 0.06 | 0.04 | -0.02 | sell |
| Paradigm Biocapital Advisors LP | 0 | 2,744,399 | +2,744,399 | 0.00 | 1.67 | +1.67 | buy |
| BlackRock, Inc. | 2,287,155 | 2,570,425 | +283,270 | 0.00 | 0.00 | -0.00 | buy |
| AH Capital Management, L.L.C. | 1,702,225 | 1,702,225 | 0 | 4.46 | 3.94 | -0.53 | hold |
| VR Adviser, LLC | 1,548,569 | 1,602,034 | +53,465 | 3.17 | 1.78 | -1.38 | buy |
| Alphabet Inc. | 1,388,583 | 1,388,583 | 0 | 2.23 | 1.03 | -1.20 | hold |
| Logos Global Management LP | 950,000 | 1,235,000 | +285,000 | 2.62 | 1.90 | -0.72 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,178,000 | +1,178,000 | 0.00 | 0.05 | +0.05 | buy |
| General Catalyst Group Management, LLC | 1,035,910 | 1,035,910 | 0 | 19.35 | 16.85 | -2.51 | hold |
| TRV GP V, LLC | 950,800 | 950,800 | 0 | 9.18 | 7.08 | -2.10 | hold |
| FMR LLC | 728,605 | 864,214 | +135,609 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 448,217 | 775,714 | +327,497 | 0.01 | 0.02 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 767,383 | 767,383 | 0 | 0.70 | 0.61 | -0.09 | hold |
| Casdin Capital, LLC | 758,857 | 758,857 | 0 | 1.95 | 1.72 | -0.24 | hold |
| Cormorant Asset Management, LP | 0 | 750,000 | +750,000 | 0.00 | 1.13 | +1.13 | buy |
| Woodline Partners LP | 1,035,229 | 650,229 | -385,000 | 0.17 | 0.07 | -0.09 | sell |
| STATE STREET CORP | 533,005 | 636,722 | +103,717 | 0.00 | 0.00 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 378,015 | 636,162 | +258,147 | 0.11 | 0.14 | +0.03 | buy |
| Caligan Partners LP | 550,191 | 614,962 | +64,771 | 2.09 | 1.30 | -0.79 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 527,281 | 599,967 | +72,686 | 0.00 | 0.00 | -0.00 | buy |
| BESSEMER GROUP INC | 481,790 | 481,790 | 0 | 0.03 | 0.02 | -0.01 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 199,212 | 461,151 | +261,939 | 0.02 | 0.03 | +0.01 | buy |
| Ikarian Capital, LLC | 644,680 | 378,999 | -265,681 | 3.46 | 1.62 | -1.84 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 373,000 | +373,000 | 0.00 | 0.07 | +0.07 | buy |
| HHLR ADVISORS, LTD. | 457,535 | 366,028 | -91,507 | 0.61 | 0.65 | +0.04 | sell |
| MARSHALL WACE, LLP | 847,472 | 310,639 | -536,833 | 0.03 | 0.01 | -0.02 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 409,372 | 284,476 | -124,896 | 0.43 | 0.20 | -0.24 | sell |
| WASHINGTON UNIVERSITY | 280,802 | 280,802 | 0 | 5.88 | 5.23 | -0.65 | hold |
| GOLDMAN SACHS GROUP INC | 114,455 | 279,713 | +165,258 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 278,167 | +278,167 | 0.00 | 0.04 | +0.04 | buy |
| Freestone Grove Partners LP | 118,876 | 234,953 | +116,077 | 0.04 | 0.05 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 71,843 | 227,343 | +155,500 | 0.62 | 1.17 | +0.55 | buy |
| Aberdeen Group plc | 0 | 226,227 | +226,227 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 176,259 | 211,382 | +35,123 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 258,086 | 204,831 | -53,255 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 18,381 | 195,084 | +176,703 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 175,969 | 186,433 | +10,464 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 185,794 | 185,794 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Foresite Capital Management IV, LLC | 522,657 | 156,901 | -365,756 | 9.43 | 1.98 | -7.45 | sell |
| Holocene Advisors, LP | 0 | 136,168 | +136,168 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 134,950 | +134,950 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 115,711 | 122,695 | +6,984 | 0.00 | 0.00 | -0.00 | buy |
| Atika Capital Management LLC | 0 | 111,500 | +111,500 | 0.00 | 0.53 | +0.53 | buy |
| AMERIPRISE FINANCIAL INC | 96,688 | 107,486 | +10,798 | 0.00 | 0.00 | -0.00 | buy |
| Alyeska Investment Group, L.P. | 196,124 | 100,000 | -96,124 | 0.02 | 0.01 | -0.01 | sell |
| Integral Health Asset Management, LLC | 100,000 | 100,000 | 0 | 0.21 | 0.16 | -0.05 | hold |
| HighVista Strategies LLC | 170,353 | 99,850 | -70,503 | 1.82 | 0.82 | -0.99 | sell |
| UBS Group AG | 28,698 | 93,898 | +65,200 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 88,510 | +88,510 | 0.00 | 1.55 | +1.55 | buy |
| Invesco Ltd. | 134,033 | 86,419 | -47,614 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 69,560 | 83,750 | +14,190 | 0.09 | 0.08 | -0.01 | buy |
| Bank of New York Mellon Corp | 60,436 | 74,268 | +13,832 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 67,718 | 69,375 | +1,657 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 33,220 | 64,762 | +31,542 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 57,258 | 63,360 | +6,102 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 61,205 | 60,587 | -618 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 59,762 | 59,943 | +181 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 55,229 | 59,637 | +4,408 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 20,007 | 58,446 | +38,439 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 179,532 | 50,095 | -129,437 | 0.56 | 0.09 | -0.47 | sell |
| D. E. Shaw & Co., Inc. | 33,694 | 45,636 | +11,942 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 0 | 43,798 | +43,798 | 0.00 | 0.82 | +0.82 | buy |
| ALPS ADVISORS INC | 0 | 39,171 | +39,171 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 37,181 | +37,181 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 35,000 | +35,000 | 0.00 | 0.24 | +0.24 | buy |
| Aquatic Capital Management LLC | 0 | 34,977 | +34,977 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 22,545 | 32,526 | +9,981 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 209,266 | 31,844 | -177,422 | 0.83 | 0.10 | -0.73 | sell |
| RHUMBLINE ADVISERS | 23,731 | 31,513 | +7,782 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 30,989 | +30,989 | 0.00 | 0.10 | +0.10 | buy |
| MILLENNIUM MANAGEMENT LLC | 154,470 | 29,892 | -124,578 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 27,439 | 27,945 | +506 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 0 | 27,945 | +27,945 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 33,021 | 26,854 | -6,167 | 0.04 | 0.01 | -0.02 | sell |
| Foresite Capital Management V, LLC | 86,291 | 25,905 | -60,386 | 2.17 | 0.29 | -1.89 | sell |
| FIRST TRUST ADVISORS LP | 0 | 25,485 | +25,485 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 25,301 | +25,301 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 24,990 | +24,990 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 21,728 | +21,728 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 15,522 | 20,263 | +4,741 | 0.00 | 0.00 | -0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 20,000 | 19,335 | -665 | 0.56 | 0.41 | -0.15 | sell |
| Verition Fund Management LLC | 22,512 | 19,134 | -3,378 | 0.01 | 0.01 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 18,127 | +18,127 | 0.00 | 0.04 | +0.04 | buy |
| Caitong International Asset Management Co., Ltd | 3,501 | 17,783 | +14,282 | 0.04 | 0.10 | +0.06 | buy |
| GILDER GAGNON HOWE & CO LLC | 23,282 | 17,487 | -5,795 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 7,245 | 15,845 | +8,600 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 27,100 | 15,800 | -11,300 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 15,110 | +15,110 | 0.00 | 0.01 | +0.01 | buy |
| DIADEMA PARTNERS LP | 0 | 15,000 | +15,000 | 0.00 | 0.18 | +0.18 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 6,897 | 14,570 | +7,673 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 11,801 | 14,542 | +2,741 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 13,612 | +13,612 | 0.00 | 0.00 | +0.00 | buy |
| Ground Swell Capital, LLC | 0 | 13,609 | +13,609 | 0.00 | 0.80 | +0.80 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,295 | 12,416 | -18,879 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,441 | 11,995 | +554 | 0.04 | 0.03 | -0.01 | buy |
| WELLS FARGO & COMPANY/MN | 24,008 | 10,369 | -13,639 | 0.00 | 0.00 | -0.00 | sell |