| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 0 | 2,744,399 | +2,744,399 | 0.00 | 1.67 | +1.67 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,178,000 | +1,178,000 | 0.00 | 0.05 | +0.05 | buy |
| Cormorant Asset Management, LP | 0 | 750,000 | +750,000 | 0.00 | 1.13 | +1.13 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 373,000 | +373,000 | 0.00 | 0.07 | +0.07 | buy |
| CITADEL ADVISORS LLC | 448,217 | 775,714 | +327,497 | 0.01 | 0.02 | +0.00 | buy |
| Logos Global Management LP | 950,000 | 1,235,000 | +285,000 | 2.62 | 1.90 | -0.72 | buy |
| BlackRock, Inc. | 2,287,155 | 2,570,425 | +283,270 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 0 | 278,167 | +278,167 | 0.00 | 0.04 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 199,212 | 461,151 | +261,939 | 0.02 | 0.03 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 378,015 | 636,162 | +258,147 | 0.11 | 0.14 | +0.03 | buy |
| Aberdeen Group plc | 0 | 226,227 | +226,227 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 18,381 | 195,084 | +176,703 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 114,455 | 279,713 | +165,258 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 71,843 | 227,343 | +155,500 | 0.62 | 1.17 | +0.55 | buy |
| Holocene Advisors, LP | 0 | 136,168 | +136,168 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 728,605 | 864,214 | +135,609 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 134,950 | +134,950 | 0.00 | 0.01 | +0.01 | buy |
| Freestone Grove Partners LP | 118,876 | 234,953 | +116,077 | 0.04 | 0.05 | +0.02 | buy |
| Atika Capital Management LLC | 0 | 111,500 | +111,500 | 0.00 | 0.53 | +0.53 | buy |
| STATE STREET CORP | 533,005 | 636,722 | +103,717 | 0.00 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 0 | 88,510 | +88,510 | 0.00 | 1.55 | +1.55 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 527,281 | 599,967 | +72,686 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 28,698 | 93,898 | +65,200 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 550,191 | 614,962 | +64,771 | 2.09 | 1.30 | -0.79 | buy |
| VR Adviser, LLC | 1,548,569 | 1,602,034 | +53,465 | 3.17 | 1.78 | -1.38 | buy |
| Propel Bio Management, LLC | 0 | 43,798 | +43,798 | 0.00 | 0.82 | +0.82 | buy |
| ALPS ADVISORS INC | 0 | 39,171 | +39,171 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 20,007 | 58,446 | +38,439 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 37,181 | +37,181 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 176,259 | 211,382 | +35,123 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 0 | 35,000 | +35,000 | 0.00 | 0.24 | +0.24 | buy |
| Aquatic Capital Management LLC | 0 | 34,977 | +34,977 | 0.00 | 0.03 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 33,220 | 64,762 | +31,542 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 30,989 | +30,989 | 0.00 | 0.10 | +0.10 | buy |
| Walleye Capital LLC | 0 | 27,945 | +27,945 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 0 | 25,485 | +25,485 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 25,301 | +25,301 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 24,990 | +24,990 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 21,728 | +21,728 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 18,127 | +18,127 | 0.00 | 0.04 | +0.04 | buy |
| Engineers Gate Manager LP | 0 | 15,110 | +15,110 | 0.00 | 0.01 | +0.01 | buy |
| DIADEMA PARTNERS LP | 0 | 15,000 | +15,000 | 0.00 | 0.18 | +0.18 | buy |
| Caitong International Asset Management Co., Ltd | 3,501 | 17,783 | +14,282 | 0.04 | 0.10 | +0.06 | buy |
| SummitTX Capital, L.P. | 69,560 | 83,750 | +14,190 | 0.09 | 0.08 | -0.01 | buy |
| Bank of New York Mellon Corp | 60,436 | 74,268 | +13,832 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 13,612 | +13,612 | 0.00 | 0.00 | +0.00 | buy |
| Ground Swell Capital, LLC | 0 | 13,609 | +13,609 | 0.00 | 0.80 | +0.80 | buy |
| D. E. Shaw & Co., Inc. | 33,694 | 45,636 | +11,942 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 96,688 | 107,486 | +10,798 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 175,969 | 186,433 | +10,464 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 22,545 | 32,526 | +9,981 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 9,139 | +9,139 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 7,245 | 15,845 | +8,600 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 8,150 | +8,150 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 23,731 | 31,513 | +7,782 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 6,897 | 14,570 | +7,673 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 7,287 | +7,287 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 7,095 | +7,095 | 0.00 | 0.03 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 115,711 | 122,695 | +6,984 | 0.00 | 0.00 | -0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 6,748 | +6,748 | 0.00 | 0.02 | +0.02 | buy |
| Nuveen, LLC | 57,258 | 63,360 | +6,102 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 3,514 | 8,988 | +5,474 | 0.00 | 0.01 | +0.00 | buy |
| Caption Management, LLC | 0 | 5,000 | +5,000 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 15,522 | 20,263 | +4,741 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 55,229 | 59,637 | +4,408 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 6,443 | 9,523 | +3,080 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 11,801 | 14,542 | +2,741 | 0.00 | 0.00 | -0.00 | buy |
| Persistent Asset Partners Ltd | 6,605 | 8,768 | +2,163 | 0.13 | 0.10 | -0.03 | buy |
| ROYAL BANK OF CANADA | 0 | 2,029 | +2,029 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 67,718 | 69,375 | +1,657 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,700 | 8,200 | +1,500 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,349 | 2,778 | +1,429 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,210 | +1,210 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 204 | 1,404 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 5,961 | 7,101 | +1,140 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 1,097 | +1,097 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,473 | 6,475 | +1,002 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,441 | 11,995 | +554 | 0.04 | 0.03 | -0.01 | buy |
| Ameritas Investment Partners, Inc. | 1,632 | 2,165 | +533 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 27,439 | 27,945 | +506 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 5,379 | 5,790 | +411 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 361 | +361 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 99 | 427 | +328 | 0.00 | 0.00 | +0.00 | buy |
| Kemnay Advisory Services Inc. | 0 | 306 | +306 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 59,762 | 59,943 | +181 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 172 | 352 | +180 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,338 | 2,510 | +172 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 6,846 | 7,016 | +170 | 0.08 | 0.06 | -0.02 | buy |
| SIGNATUREFD, LLC | 14 | 169 | +155 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 944 | 1,080 | +136 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,321 | 1,435 | +114 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 149 | 203 | +54 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 10 | 20 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 5 | 14 | +9 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 3 | +3 | 0.00 | 0.00 | 0.00 | buy |
| Stone House Investment Management, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Hughes Financial Services, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |