| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 3,269,126 | 3,948,910 | +679,784 | 1.17 | 1.56 | +0.39 | buy |
| Frazier Life Sciences Management, L.P. | 4,129,001 | 4,567,275 | +438,274 | 2.08 | 2.24 | +0.16 | buy |
| JANUS HENDERSON GROUP PLC | 1,246,370 | 1,401,260 | +154,890 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 64,713 | 144,685 | +79,972 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 132,115 | 193,400 | +61,285 | 0.01 | 0.02 | +0.00 | buy |
| STRS OHIO | 1,600 | 46,900 | +45,300 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 582,588 | 614,704 | +32,116 | 0.00 | 0.00 | +0.00 | buy |
| CW Advisors, LLC | 0 | 30,235 | +30,235 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 27,467 | +27,467 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 23,577 | +23,577 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 212,464 | 231,237 | +18,773 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 18,539 | +18,539 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 70,838 | 85,546 | +14,708 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 929,102 | 940,700 | +11,598 | 0.07 | 0.06 | -0.01 | buy |
| Engineers Gate Manager LP | 0 | 10,212 | +10,212 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 6,940 | +6,940 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 6,216 | 12,990 | +6,774 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 17,233 | 21,546 | +4,313 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 834 | 4,608 | +3,774 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 871 | 4,242 | +3,371 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 72,305 | 75,171 | +2,866 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 2,266 | +2,266 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 4,693 | 5,615 | +922 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 355,554 | 356,453 | +899 | 0.97 | 1.14 | +0.18 | buy |
| RHUMBLINE ADVISERS | 7,235 | 7,714 | +479 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 26 | 505 | +479 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 400 | 759 | +359 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 182 | +182 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 74 | 224 | +150 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 114 | +114 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 51 | +51 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 18 | 26 | +8 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 481,790 | 481,790 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 894 | 894 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 554 | 554 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARVARD MANAGEMENT CO INC | 637,528 | 637,528 | 0 | 0.62 | 0.54 | -0.08 | hold |
| ARCH Venture Management, LLC | 4,120,053 | 4,120,053 | 0 | 22.00 | 16.91 | -5.08 | hold |
| MARSHALL WACE, LLP | 19,597 | 19,597 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Matrix Capital Management Company, LP | 2,486,184 | 2,486,184 | 0 | 7.88 | 13.69 | +5.81 | hold |
| Alyeska Investment Group, L.P. | 125,000 | 125,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| AH Capital Management, L.L.C. | 1,702,225 | 1,702,225 | 0 | 2.67 | 6.67 | +4.00 | hold |
| General Catalyst Group Management, LLC | 1,035,910 | 1,035,910 | 0 | 1.29 | 0.30 | -0.99 | hold |
| Alphabet Inc. | 2,412,471 | 2,412,471 | 0 | 1.68 | 1.39 | -0.30 | hold |
| TRV GP IV, LLC | 6,073,958 | 6,073,958 | 0 | 72.02 | 45.63 | -26.39 | hold |
| Foresite Capital Management IV, LLC | 2,111,919 | 2,111,919 | 0 | 20.93 | 20.93 | -0.00 | hold |
| HHLR ADVISORS, LTD. | 457,535 | 457,535 | 0 | 0.14 | 0.18 | +0.04 | hold |
| Foresite Capital Management V, LLC | 345,191 | 345,191 | 0 | 4.34 | 5.25 | +0.91 | hold |
| Ghisallo Capital Management LLC | 30,000 | 30,000 | 0 | 0.03 | 0.01 | -0.02 | hold |
| Nuveen, LLC | 11,375 | 11,375 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TRV GP V, LLC | 950,800 | 950,800 | 0 | 8.37 | 7.04 | -1.33 | hold |
| Police & Firemen's Retirement System of New Jersey | 2,241 | 2,241 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,300 | 2,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 305 | 305 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 8,885 | 8,885 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 14,644 | 14,641 | -3 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,135 | 4,901 | -234 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 636 | 0 | -636 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 20,552 | 18,430 | -2,122 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 4,328 | 0 | -4,328 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 10,141 | 0 | -10,141 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 13,129 | 0 | -13,129 | 0.00 | 0.00 | -0.00 | sell |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 13,670 | 0 | -13,670 | 0.00 | 0.00 | -0.00 | sell |
| OXFORD ASSET MANAGEMENT LLP | 17,000 | 0 | -17,000 | 0.09 | 0.00 | -0.09 | sell |
| CITADEL ADVISORS LLC | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 96,968 | 75,530 | -21,438 | 0.04 | 0.03 | -0.01 | sell |
| UBS Group AG | 88,064 | 51,402 | -36,662 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 322,740 | 262,740 | -60,000 | 1.16 | 1.07 | -0.09 | sell |
| Casdin Capital, LLC | 946,357 | 758,857 | -187,500 | 0.85 | 0.85 | -0.00 | sell |
| VANGUARD GROUP INC | 666,554 | 419,613 | -246,941 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 250,000 | 0 | -250,000 | 0.43 | 0.00 | -0.43 | sell |
| Octagon Capital Advisors LP | 468,000 | 177,667 | -290,333 | 0.70 | 0.48 | -0.23 | sell |
| Logos Global Management LP | 936,914 | 611,914 | -325,000 | 1.83 | 1.00 | -0.83 | sell |
| FMR LLC | 968,383 | 554,534 | -413,849 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,016,446 | 31,796 | -984,650 | 0.00 | 0.00 | -0.00 | sell |