| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 4,567,274 | 5,032,915 | +465,641 | 3.51 | 3.27 | -0.24 | buy |
| TRV GP IV, LLC | 4,473,958 | 4,473,958 | 0 | 50.04 | 52.63 | +2.59 | hold |
| ARCH Venture Management, LLC | 4,120,053 | 4,120,053 | 0 | 18.16 | 11.18 | -6.99 | hold |
| Deep Track Capital, LP | 3,477,562 | 3,732,569 | +255,007 | 2.14 | 1.64 | -0.50 | buy |
| BlackRock, Inc. | 2,570,425 | 3,502,841 | +932,416 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 2,603,682 | +2,603,682 | 0.00 | 0.05 | +0.05 | buy |
| Logos Global Management LP | 1,235,000 | 1,935,000 | +700,000 | 1.90 | 2.49 | +0.59 | buy |
| AH Capital Management, L.L.C. | 1,702,225 | 1,702,225 | 0 | 3.94 | 0.36 | -3.58 | hold |
| VR Adviser, LLC | 1,602,034 | 1,602,034 | 0 | 1.78 | 1.45 | -0.34 | hold |
| Alphabet Inc. | 1,388,583 | 1,388,583 | 0 | 1.03 | 0.04 | -0.99 | hold |
| BRAIDWELL LP | 0 | 1,140,040 | +1,140,040 | 0.00 | 1.26 | +1.26 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 373,000 | 1,107,814 | +734,814 | 0.07 | 0.19 | +0.13 | buy |
| FMR LLC | 864,214 | 1,056,959 | +192,745 | 0.00 | 0.00 | +0.00 | buy |
| General Catalyst Group Management, LLC | 1,035,910 | 1,035,910 | 0 | 16.85 | 16.40 | -0.45 | hold |
| STATE STREET CORP | 636,722 | 997,533 | +360,811 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 58,446 | 964,011 | +905,565 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 636,162 | 954,886 | +318,724 | 0.14 | 0.17 | +0.03 | buy |
| TRV GP V, LLC | 950,800 | 950,800 | 0 | 7.08 | 5.69 | -1.38 | hold |
| MARSHALL WACE, LLP | 310,639 | 914,572 | +603,933 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 599,967 | 858,054 | +258,087 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 775,714 | 852,676 | +76,962 | 0.02 | 0.01 | -0.00 | buy |
| Casdin Capital, LLC | 758,857 | 843,857 | +85,000 | 1.72 | 1.26 | -0.45 | buy |
| ArrowMark Colorado Holdings LLC | 767,383 | 767,383 | 0 | 0.61 | 0.95 | +0.34 | hold |
| Woodline Partners LP | 650,229 | 736,216 | +85,987 | 0.07 | 0.07 | -0.01 | buy |
| BESSEMER GROUP INC | 481,790 | 481,790 | 0 | 0.02 | 0.02 | -0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 227,343 | 417,564 | +190,221 | 1.17 | 1.78 | +0.62 | buy |
| Aberdeen Group plc | 226,227 | 383,773 | +157,546 | 0.01 | 0.02 | +0.01 | buy |
| Ikarian Capital, LLC | 378,999 | 378,999 | 0 | 1.62 | 1.85 | +0.23 | hold |
| HHLR ADVISORS, LTD. | 366,028 | 366,028 | 0 | 0.65 | 1.31 | +0.66 | hold |
| ADAR1 Capital Management, LLC | 50,095 | 339,276 | +289,181 | 0.09 | 0.48 | +0.39 | buy |
| BANK OF AMERICA CORP /DE/ | 195,084 | 321,227 | +126,143 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 211,382 | 294,742 | +83,360 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 279,713 | 293,144 | +13,431 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 278,167 | 273,932 | -4,235 | 0.04 | 0.04 | -0.01 | sell |
| Hudson Bay Capital Management LP | 8,150 | 270,000 | +261,850 | 0.00 | 0.04 | +0.04 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 260,566 | +260,566 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 186,433 | 260,566 | +74,133 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,178,000 | 248,000 | -930,000 | 0.05 | 0.01 | -0.04 | sell |
| AMERIPRISE FINANCIAL INC | 107,486 | 227,425 | +119,939 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 212,000 | +212,000 | 0.00 | 0.05 | +0.05 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 37,181 | 199,872 | +162,691 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 15,845 | 192,952 | +177,107 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 284,476 | 188,857 | -95,619 | 0.20 | 0.11 | -0.09 | sell |
| ExodusPoint Capital Management, LP | 0 | 183,264 | +183,264 | 0.00 | 0.05 | +0.05 | buy |
| SummitTX Capital, L.P. | 83,750 | 176,291 | +92,541 | 0.08 | 0.14 | +0.06 | buy |
| HighVista Strategies LLC | 99,850 | 136,572 | +36,722 | 0.82 | 0.93 | +0.11 | buy |
| MORGAN STANLEY | 204,831 | 135,168 | -69,663 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 122,695 | 132,870 | +10,175 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 134,950 | 131,043 | -3,907 | 0.01 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 27,945 | 128,006 | +100,061 | 0.01 | 0.02 | +0.01 | buy |
| Exome Asset Management LLC | 88,510 | 114,692 | +26,182 | 1.55 | 2.11 | +0.56 | buy |
| Ensign Peak Advisors, Inc | 185,794 | 101,644 | -84,150 | 0.01 | 0.00 | -0.01 | sell |
| Alyeska Investment Group, L.P. | 100,000 | 100,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Bank of New York Mellon Corp | 74,268 | 97,588 | +23,320 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 93,357 | +93,357 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 93,898 | 84,679 | -9,219 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 60,587 | 82,724 | +22,137 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 81,668 | +81,668 | 0.00 | 0.02 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 59,637 | 80,216 | +20,579 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 63,360 | 78,468 | +15,108 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 59,943 | 77,850 | +17,907 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,475 | 77,251 | +70,776 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 26,854 | 75,317 | +48,463 | 0.01 | 0.03 | +0.02 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 9,420 | 74,384 | +64,964 | 0.00 | 0.01 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 69,375 | 66,353 | -3,022 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 65,468 | +65,468 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 35,000 | 65,000 | +30,000 | 0.24 | 0.37 | +0.13 | buy |
| ALPS ADVISORS INC | 39,171 | 55,970 | +16,799 | 0.01 | 0.01 | +0.00 | buy |
| Jump Financial, LLC | 0 | 47,129 | +47,129 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 0 | 47,100 | +47,100 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 25,485 | 46,227 | +20,742 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 43,798 | 43,798 | 0 | 0.82 | 0.68 | -0.14 | hold |
| RHUMBLINE ADVISERS | 31,513 | 42,873 | +11,360 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 64,762 | 37,800 | -26,962 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 20,263 | 34,993 | +14,730 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,369 | 32,047 | +21,678 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 8,563 | 30,265 | +21,702 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 30,047 | +30,047 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 86,419 | 28,372 | -58,047 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 27,945 | 27,161 | -784 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,435 | 26,063 | +24,628 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 23,840 | +23,840 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 9,262 | 23,733 | +14,471 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,301 | 23,677 | -1,624 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 0 | 22,174 | +22,174 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 14,542 | 20,899 | +6,357 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 461,151 | 20,190 | -440,961 | 0.03 | 0.00 | -0.03 | sell |
| Squarepoint Ops LLC | 13,612 | 19,434 | +5,822 | 0.00 | 0.00 | +0.00 | buy |
| Jackson Creek Investment Advisors LLC | 0 | 18,345 | +18,345 | 0.00 | 0.16 | +0.16 | buy |
| Verition Fund Management LLC | 19,134 | 18,201 | -933 | 0.01 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 427 | 17,739 | +17,312 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,570 | 16,402 | +1,832 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12,416 | 16,248 | +3,832 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 5,790 | 15,781 | +9,991 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 7,095 | 15,193 | +8,098 | 0.03 | 0.05 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 21,728 | 14,370 | -7,358 | 0.01 | 0.01 | -0.00 | sell |
| Russell Investments Group, Ltd. | 32,526 | 14,131 | -18,395 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,995 | 13,808 | +1,813 | 0.03 | 0.02 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 7,016 | 13,605 | +6,589 | 0.06 | 0.09 | +0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,200 | 12,400 | +4,200 | 0.00 | 0.00 | +0.00 | buy |