| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 0 | 1,230,769 | +1,230,769 | 0.00 | 1.80 | +1.80 | buy |
| VANGUARD GROUP INC | 419,613 | 1,334,955 | +915,342 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 19,597 | 777,701 | +758,104 | 0.00 | 0.02 | +0.02 | buy |
| BlackRock, Inc. | 614,704 | 1,316,016 | +701,312 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 611,914 | 1,227,300 | +615,386 | 1.00 | 3.14 | +2.14 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 545,132 | +545,132 | 0.00 | 0.26 | +0.26 | buy |
| Ikarian Capital, LLC | 262,740 | 740,825 | +478,085 | 1.07 | 3.89 | +2.82 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 433,725 | +433,725 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 75,530 | 351,875 | +276,345 | 0.03 | 0.23 | +0.20 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 231,237 | 473,549 | +242,312 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 144,685 | 384,702 | +240,017 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 212,762 | +212,762 | 0.00 | 0.00 | +0.00 | buy |
| WASHINGTON UNIVERSITY | 0 | 210,681 | +210,681 | 0.00 | 3.06 | +3.06 | buy |
| Parkman Healthcare Partners LLC | 0 | 200,000 | +200,000 | 0.00 | 0.57 | +0.57 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 193,400 | 378,015 | +184,615 | 0.02 | 0.07 | +0.05 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 114,049 | +114,049 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 18,430 | 132,062 | +113,632 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 554,534 | 655,614 | +101,080 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 940,700 | 1,035,229 | +94,529 | 0.06 | 0.13 | +0.07 | buy |
| Nantahala Capital Management, LLC | 0 | 93,351 | +93,351 | 0.00 | 0.15 | +0.15 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 75,171 | 167,928 | +92,757 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 85,546 | 176,890 | +91,344 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 86,100 | +86,100 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 18,539 | 70,665 | +52,126 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 30,525 | +30,525 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 31,796 | 60,100 | +28,304 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 26,867 | +26,867 | 0.00 | 0.04 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 0 | 26,045 | +26,045 | 0.00 | 0.07 | +0.07 | buy |
| Bank of New York Mellon Corp | 21,546 | 45,240 | +23,694 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 11,375 | 30,304 | +18,929 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 18,198 | +18,198 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 16,165 | +16,165 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 14,487 | +14,487 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 7,714 | 20,970 | +13,256 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 14,641 | 27,516 | +12,875 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 11,801 | +11,801 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 759 | 12,018 | +11,259 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 11,150 | +11,150 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 10,474 | +10,474 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 5,615 | 14,779 | +9,164 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 7,890 | +7,890 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 5,015 | +5,015 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,300 | 6,700 | +4,400 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,901 | 9,078 | +4,177 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 4,000 | +4,000 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 2,241 | 5,030 | +2,789 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 182 | 1,907 | +1,725 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 6,940 | 8,397 | +1,457 | 0.03 | 0.06 | +0.03 | buy |
| Sterling Capital Management LLC | 224 | 1,260 | +1,036 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,242 | 5,219 | +977 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 894 | 1,632 | +738 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 383 | +383 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 307 | +307 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 27,467 | 27,615 | +148 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 51 | 159 | +108 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 114 | 149 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Sunbelt Securities, Inc. | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 554 | 555 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 481,790 | 481,790 | 0 | 0.01 | 0.02 | +0.01 | hold |
| ARCH Venture Management, LLC | 4,120,053 | 4,120,053 | 0 | 16.91 | 21.70 | +4.78 | hold |
| Alyeska Investment Group, L.P. | 125,000 | 125,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Casdin Capital, LLC | 758,857 | 758,857 | 0 | 0.85 | 1.64 | +0.79 | hold |
| AH Capital Management, L.L.C. | 1,702,225 | 1,702,225 | 0 | 6.67 | 3.16 | -3.51 | hold |
| General Catalyst Group Management, LLC | 1,035,910 | 1,035,910 | 0 | 0.30 | 0.88 | +0.59 | hold |
| Alphabet Inc. | 2,412,471 | 2,412,471 | 0 | 1.39 | 2.60 | +1.21 | hold |
| TRV GP IV, LLC | 6,073,958 | 6,073,958 | 0 | 45.63 | 57.49 | +11.86 | hold |
| HHLR ADVISORS, LTD. | 457,535 | 457,535 | 0 | 0.18 | 0.29 | +0.11 | hold |
| Octagon Capital Advisors LP | 177,667 | 177,667 | 0 | 0.48 | 0.72 | +0.24 | hold |
| Deep Track Capital, LP | 3,948,910 | 3,948,910 | 0 | 1.56 | 2.86 | +1.30 | hold |
| True Wealth Design, LLC | 5 | 5 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TRV GP V, LLC | 950,800 | 950,800 | 0 | 7.04 | 6.97 | -0.07 | hold |
| AMALGAMATED BANK | 305 | 305 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 26 | 26 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 8,885 | 8,885 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Frazier Life Sciences Management, L.P. | 4,567,275 | 4,567,274 | -1 | 2.24 | 3.55 | +1.31 | sell |
| IFP Advisors, Inc | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 2,266 | 2,138 | -128 | 0.00 | 0.00 | +0.00 | sell |
| SBI Securities Co., Ltd. | 505 | 61 | -444 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 4,608 | 2,012 | -2,596 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 23,577 | 13,742 | -9,835 | 0.00 | 0.00 | +0.00 | sell |
| Engineers Gate Manager LP | 10,212 | 0 | -10,212 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 12,990 | 269 | -12,721 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 51,402 | 27,793 | -23,609 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 46,900 | 17,900 | -29,000 | 0.00 | 0.00 | -0.00 | sell |
| Ghisallo Capital Management LLC | 30,000 | 0 | -30,000 | 0.01 | 0.00 | -0.01 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 356,453 | 154,343 | -202,110 | 1.14 | 0.95 | -0.19 | sell |
| Foresite Capital Management V, LLC | 345,191 | 86,291 | -258,900 | 5.25 | 2.06 | -3.19 | sell |
| HARVARD MANAGEMENT CO INC | 637,528 | 92,396 | -545,132 | 0.54 | 0.11 | -0.43 | sell |
| JANUS HENDERSON GROUP PLC | 1,401,260 | 751,874 | -649,386 | 0.01 | 0.01 | +0.00 | sell |
| Matrix Capital Management Company, LP | 2,486,184 | 1,653,684 | -832,500 | 13.69 | 40.17 | +26.48 | sell |
| Foresite Capital Management IV, LLC | 2,111,919 | 522,657 | -1,589,262 | 20.93 | 7.42 | -13.51 | sell |