| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 751,874 | 3,142,587 | +2,390,713 | 0.01 | 0.06 | +0.05 | buy |
| BlackRock, Inc. | 1,316,016 | 2,287,155 | +971,139 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 0 | 887,708 | +887,708 | 0.00 | 0.70 | +0.70 | buy |
| Caligan Partners LP | 0 | 550,191 | +550,191 | 0.00 | 2.09 | +2.09 | buy |
| CITADEL ADVISORS LLC | 0 | 448,217 | +448,217 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 1,334,955 | 1,697,015 | +362,060 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 324,041 | +324,041 | 0.00 | 0.21 | +0.21 | buy |
| VR Adviser, LLC | 1,230,769 | 1,548,569 | +317,800 | 1.80 | 3.17 | +1.37 | buy |
| Deep Track Capital, LP | 3,948,910 | 4,246,440 | +297,530 | 2.86 | 4.01 | +1.16 | buy |
| ArrowMark Colorado Holdings LLC | 545,132 | 767,383 | +222,251 | 0.26 | 0.70 | +0.44 | buy |
| TCG Crossover Management, LLC | 0 | 173,816 | +173,816 | 0.00 | 0.24 | +0.24 | buy |
| HighVista Strategies LLC | 0 | 170,353 | +170,353 | 0.00 | 1.82 | +1.82 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 154,470 | +154,470 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 26,045 | 179,532 | +153,487 | 0.07 | 0.56 | +0.49 | buy |
| STATE STREET CORP | 384,702 | 533,005 | +148,303 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 125,877 | +125,877 | 0.00 | 0.89 | +0.89 | buy |
| Freestone Grove Partners LP | 0 | 118,876 | +118,876 | 0.00 | 0.04 | +0.04 | buy |
| Ensign Peak Advisors, Inc | 70,665 | 185,794 | +115,129 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 114,455 | +114,455 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,474 | 115,711 | +105,237 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.21 | +0.21 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 96,688 | +96,688 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 81,145 | +81,145 | 0.00 | 0.38 | +0.38 | buy |
| FMR LLC | 655,614 | 728,605 | +72,991 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 125,000 | 196,124 | +71,124 | 0.01 | 0.02 | +0.01 | buy |
| WASHINGTON UNIVERSITY | 210,681 | 280,802 | +70,121 | 3.06 | 5.88 | +2.82 | buy |
| MARSHALL WACE, LLP | 777,701 | 847,472 | +69,771 | 0.02 | 0.03 | +0.01 | buy |
| SummitTX Capital, L.P. | 0 | 69,560 | +69,560 | 0.00 | 0.09 | +0.09 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 67,718 | +67,718 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 61,205 | +61,205 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 351,875 | 409,372 | +57,497 | 0.23 | 0.43 | +0.20 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 473,549 | 527,281 | +53,732 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 52,459 | +52,459 | 0.00 | 0.02 | +0.02 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.16 | +0.16 | buy |
| MORGAN STANLEY | 212,762 | 258,086 | +45,324 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 18,198 | 55,229 | +37,031 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 33,694 | +33,694 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 30,525 | 59,762 | +29,237 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 29,134 | +29,134 | 0.00 | 0.07 | +0.07 | buy |
| Nuveen, LLC | 30,304 | 57,258 | +26,954 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 24,059 | +24,059 | 0.00 | 0.01 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 23,282 | +23,282 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 22,512 | +22,512 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,078 | 31,295 | +22,217 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 21,509 | +21,509 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,907 | 22,545 | +20,638 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.56 | +0.56 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 19,100 | +19,100 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 18,381 | +18,381 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 45,240 | 60,436 | +15,196 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 14,800 | +14,800 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 7,890 | 20,007 | +12,117 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 27,516 | 39,508 | +11,992 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 269 | 11,252 | +10,983 | 0.00 | 0.00 | +0.00 | buy |
| Falcon Wealth Planning | 0 | 10,030 | +10,030 | 0.00 | 0.03 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 2,000 | 11,441 | +9,441 | 0.00 | 0.04 | +0.03 | buy |
| Parkman Healthcare Partners LLC | 200,000 | 209,266 | +9,266 | 0.57 | 0.83 | +0.26 | buy |
| WELLS FARGO & COMPANY/MN | 14,779 | 24,008 | +9,229 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 167,928 | 175,969 | +8,041 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 6,897 | +6,897 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 8,885 | 15,522 | +6,637 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 6,605 | +6,605 | 0.00 | 0.13 | +0.13 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 6,443 | +6,443 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 26,867 | 33,021 | +6,154 | 0.04 | 0.04 | -0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 6,050 | +6,050 | 0.00 | 0.02 | +0.02 | buy |
| ProShare Advisors LLC | 0 | 6,047 | +6,047 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 6,016 | +6,016 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 0 | 5,668 | +5,668 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 5,400 | +5,400 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 5,244 | +5,244 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 5,221 | +5,221 | 0.00 | 0.01 | +0.01 | buy |
| WestHill Financial Advisors, Inc. | 0 | 5,186 | +5,186 | 0.00 | 0.04 | +0.04 | buy |
| Brevan Howard Capital Management LP | 0 | 5,042 | +5,042 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 3,514 | +3,514 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 3,501 | +3,501 | 0.00 | 0.04 | +0.04 | buy |
| SG Americas Securities, LLC | 5,015 | 8,493 | +3,478 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 20,970 | 23,731 | +2,761 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 2,338 | +2,338 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 132,062 | 134,033 | +1,971 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 0 | 944 | +944 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 5,030 | 5,961 | +931 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 27,793 | 28,698 | +905 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 555 | 1,321 | +766 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 305 | 674 | +369 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 26 | 204 | +178 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 160 | +160 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 5,219 | 5,379 | +160 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 99 | +99 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 2,138 | 2,229 | +91 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 90 | +90 | 0.00 | 0.00 | +0.00 | buy |
| SageView Advisory Group, LLC | 0 | 54 | +54 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 159 | 172 | +13 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 61 | 67 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 481,790 | 481,790 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Ameritas Investment Partners, Inc. | 1,632 | 1,632 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ARCH Venture Management, LLC | 4,120,053 | 4,120,053 | 0 | 21.70 | 26.19 | +4.49 | hold |
| MetLife Investment Management, LLC | 11,801 | 11,801 | 0 | 0.00 | 0.00 | +0.00 | hold |