| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 0 | 6,963,141 | +6,963,141 | 0.00 | 0.74 | +0.74 | buy |
| Octagon Capital Advisors LP | 0 | 5,250,000 | +5,250,000 | 0.00 | 1.52 | +1.52 | buy |
| TCG Crossover Management, LLC | 0 | 2,682,696 | +2,682,696 | 0.00 | 0.20 | +0.20 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 1,093,894 | +1,093,894 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 0 | 529,550 | +529,550 | 0.00 | 0.07 | +0.07 | buy |
| JANE STREET GROUP, LLC | 0 | 436,931 | +436,931 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 2,593,198 | 2,948,441 | +355,243 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 287,299 | +287,299 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 250,088 | +250,088 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 140,017 | +140,017 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 104,973 | +104,973 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 81,303 | +81,303 | 0.00 | 0.01 | +0.01 | buy |
| OMERS ADMINISTRATION Corp | 0 | 80,600 | +80,600 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 165,607 | 233,507 | +67,900 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 50,912 | +50,912 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 84,281 | 103,256 | +18,975 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 12,573 | +12,573 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 15,084 | 26,534 | +11,450 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 11,398 | +11,398 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,348 | 12,182 | +10,834 | 0.00 | 0.00 | +0.00 | buy |
| Legacy Capital Wealth Partners, LLC | 0 | 10,315 | +10,315 | 0.00 | 0.01 | +0.01 | buy |
| FNY Investment Advisers, LLC | 0 | 6,000 | +6,000 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 52,701 | 57,231 | +4,530 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 125,852 | 126,152 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 92,804 | 92,804 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Cerity Partners LLC | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nextech Invest, Ltd. | 7,419,355 | 7,419,355 | 0 | 1.05 | 1.37 | +0.31 | hold |
| MPM BioImpact LLC | 10,679,391 | 10,679,391 | 0 | 1.80 | 2.16 | +0.36 | hold |
| Velan Capital Investment Management LP | 100,000 | 100,000 | 0 | 0.09 | 0.16 | +0.08 | hold |
| Deep Track Capital, LP | 7,419,355 | 7,419,355 | 0 | 0.25 | 0.40 | +0.15 | hold |
| ADAR1 Capital Management, LLC | 351,094 | 351,094 | 0 | 0.04 | 0.06 | +0.02 | hold |
| Mill Creek Capital Advisors, LLC | 104,631 | 104,631 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Farther Finance Advisors, LLC | 1,500 | 1,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pathstone Holdings, LLC | 110,244 | 110,244 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 114 | 78 | -36 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 848,046 | 846,696 | -1,350 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 608,462 | 603,767 | -4,695 | 0.00 | 0.00 | +0.00 | sell |
| Virtu Financial LLC | 28,921 | 23,100 | -5,821 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 9,611 | 1,232 | -8,379 | 0.00 | 0.00 | -0.00 | sell |
| CAXTON CORP | 18,403 | 0 | -18,403 | 0.63 | 0.00 | -0.63 | sell |
| Nantahala Capital Management, LLC | 37,837 | 0 | -37,837 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 46,220 | 0 | -46,220 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 101,605 | 0 | -101,605 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 132,786 | 0 | -132,786 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 4,003,380 | 3,803,338 | -200,042 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 508,329 | 182,999 | -325,330 | 0.00 | 0.00 | -0.00 | sell |
| Sio Capital Management, LLC | 1,341,636 | 917,922 | -423,714 | 0.33 | 0.35 | +0.02 | sell |
| Avidity Partners Management LP | 5,504,855 | 4,998,267 | -506,588 | 2.33 | 2.65 | +0.32 | sell |
| MILLENNIUM MANAGEMENT LLC | 2,601,216 | 1,424,374 | -1,176,842 | 0.00 | 0.00 | +0.00 | sell |
| Alyeska Investment Group, L.P. | 1,663,355 | 0 | -1,663,355 | 0.01 | 0.00 | -0.01 | sell |
| Blue Owl Capital Holdings LP | 7,432,906 | 5,089,015 | -2,343,891 | 3.37 | 3.58 | +0.21 | sell |
| Blackstone Inc. | 2,440,330 | 0 | -2,440,330 | 0.02 | 0.00 | -0.02 | sell |
| GREAT POINT PARTNERS LLC | 4,683,711 | 2,238,496 | -2,445,215 | 2.23 | 1.44 | -0.80 | sell |