| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 846,696 | 6,169,250 | +5,322,554 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 603,767 | 1,830,309 | +1,226,542 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 233,507 | 1,413,428 | +1,179,921 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,010,904 | +1,010,904 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 182,999 | 1,041,399 | +858,400 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 103,256 | 615,576 | +512,320 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 351,094 | 750,969 | +399,875 | 0.06 | 0.02 | -0.04 | buy |
| XTX Topco Ltd | 0 | 294,301 | +294,301 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 11,398 | 257,068 | +245,670 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 227,850 | +227,850 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 227,850 | +227,850 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 436,931 | 645,209 | +208,278 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 163,527 | +163,527 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 159,804 | +159,804 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 135,300 | +135,300 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 0 | 125,852 | +125,852 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 125,518 | +125,518 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 109,362 | +109,362 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 110,244 | 214,875 | +104,631 | 0.00 | 0.00 | -0.00 | buy |
| Soleus Capital Management, L.P. | 6,963,141 | 7,063,141 | +100,000 | 0.74 | 0.13 | -0.60 | buy |
| NATIXIS | 0 | 97,109 | +97,109 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 90,882 | +90,882 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 77,538 | +77,538 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 69,844 | +69,844 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 59,000 | +59,000 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 12,182 | 70,323 | +58,141 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 52,709 | +52,709 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 50,617 | +50,617 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 12,573 | 61,444 | +48,871 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 42,898 | +42,898 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,232 | 29,331 | +28,099 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 27,504 | +27,504 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 25,941 | +25,941 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 20,000 | 40,000 | +20,000 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 15,462 | +15,462 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 14,233 | +14,233 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 13,390 | +13,390 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 12,199 | +12,199 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 0 | 11,796 | +11,796 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 9,074 | +9,074 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 8,455 | +8,455 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 327 | +327 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 92,804 | 92,804 | 0 | 0.02 | 0.00 | -0.01 | hold |
| Nextech Invest, Ltd. | 7,419,355 | 7,419,355 | 0 | 1.37 | 0.20 | -1.17 | hold |
| FNY Investment Advisers, LLC | 6,000 | 6,000 | 0 | 0.01 | 0.00 | -0.01 | hold |
| Avidity Partners Management LP | 4,998,267 | 4,998,267 | 0 | 2.65 | 0.44 | -2.21 | hold |
| TCG Crossover Management, LLC | 2,682,696 | 2,682,696 | 0 | 0.20 | 0.04 | -0.17 | hold |
| SBI Securities Co., Ltd. | 78 | 78 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Deep Track Capital, LP | 7,419,355 | 7,419,355 | 0 | 0.40 | 0.06 | -0.34 | hold |
| FRANKLIN RESOURCES INC | 3,803,338 | 3,803,338 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighTower Advisors, LLC | 126,152 | 125,852 | -300 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 1,500 | 0 | -1,500 | 0.00 | 0.00 | -0.00 | sell |
| Legacy Capital Wealth Partners, LLC | 10,315 | 0 | -10,315 | 0.01 | 0.00 | -0.01 | sell |
| Virtu Financial LLC | 23,100 | 0 | -23,100 | 0.00 | 0.00 | -0.00 | sell |
| Corient Private Wealth LLC | 26,534 | 0 | -26,534 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 100,000 | 59,700 | -40,300 | 0.16 | 0.02 | -0.14 | sell |
| AMERICAN CENTURY COMPANIES INC | 50,912 | 0 | -50,912 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 57,231 | 0 | -57,231 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 80,600 | 0 | -80,600 | 0.00 | 0.00 | -0.00 | sell |
| WINTON GROUP Ltd | 81,303 | 0 | -81,303 | 0.01 | 0.00 | -0.01 | sell |
| HRT FINANCIAL LP | 104,973 | 0 | -104,973 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 140,017 | 0 | -140,017 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 250,088 | 77,933 | -172,155 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 287,299 | 0 | -287,299 | 0.00 | 0.00 | -0.00 | sell |
| Cormorant Asset Management, LP | 529,550 | 0 | -529,550 | 0.07 | 0.00 | -0.07 | sell |
| Sio Capital Management, LLC | 917,922 | 0 | -917,922 | 0.35 | 0.00 | -0.35 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,000 | 0 | -1,000,000 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,093,894 | 0 | -1,093,894 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,424,374 | 147,287 | -1,277,087 | 0.00 | 0.00 | -0.00 | sell |
| Blue Owl Capital Holdings LP | 5,089,015 | 2,934,015 | -2,155,000 | 3.58 | 0.25 | -3.34 | sell |
| Octagon Capital Advisors LP | 5,250,000 | 3,050,000 | -2,200,000 | 1.52 | 0.16 | -1.37 | sell |
| GREAT POINT PARTNERS LLC | 2,238,496 | 0 | -2,238,496 | 1.44 | 0.00 | -1.44 | sell |
| MARSHALL WACE, LLP | 2,948,441 | 384,528 | -2,563,913 | 0.01 | 0.00 | -0.01 | sell |
| MPM BioImpact LLC | 10,679,391 | 1,299,046 | -9,380,345 | 2.16 | 0.04 | -2.12 | sell |