| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 14,705,882 | 14,705,882 | 0 | 1.67 | 2.33 | +0.66 | hold |
| Avidity Partners Management LP | 7,477,255 | 8,981,855 | +1,504,600 | 0.98 | 1.98 | +1.00 | buy |
| Nextech Invest, Ltd. | 7,419,355 | 7,419,355 | 0 | 0.92 | 1.09 | +0.17 | hold |
| Deep Track Capital, LP | 7,419,355 | 7,419,355 | 0 | 0.16 | 0.20 | +0.04 | hold |
| Blue Owl Capital Holdings LP | 7,407,906 | 7,407,906 | 0 | 1.57 | 2.23 | +0.66 | hold |
| GREAT POINT PARTNERS LLC | 4,683,711 | 4,683,711 | 0 | 2.00 | 1.89 | -0.10 | hold |
| FRANKLIN RESOURCES INC | 4,003,380 | 4,003,380 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VANGUARD GROUP INC | 3,360,582 | 3,495,031 | +134,449 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 2,440,330 | 2,440,330 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Alyeska Investment Group, L.P. | 1,663,355 | 1,663,355 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nantahala Capital Management, LLC | 1,935,484 | 1,661,950 | -273,534 | 0.09 | 0.10 | +0.01 | sell |
| Sio Capital Management, LLC | 1,341,636 | 1,341,636 | 0 | 0.35 | 0.33 | -0.02 | hold |
| BlackRock, Inc. | 848,970 | 848,970 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 637,810 | 608,577 | -29,233 | 0.00 | 0.00 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 518,025 | 402,653 | -115,372 | 0.05 | 0.04 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 351,094 | 351,094 | 0 | 0.04 | 0.03 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 363,930 | 320,127 | -43,803 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 152,607 | 152,607 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Walleye Capital LLC | 132,786 | 132,786 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighTower Advisors, LLC | 125,852 | 125,852 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pathstone Holdings, LLC | 0 | 110,244 | +110,244 | 0.00 | 0.00 | +0.00 | buy |
| Mill Creek Capital Advisors, LLC | 104,631 | 104,631 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Velan Capital Investment Management LP | 100,000 | 100,000 | 0 | 0.07 | 0.09 | +0.03 | hold |
| Clear Harbor Asset Management, LLC | 57,804 | 92,804 | +35,000 | 0.00 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 106,779 | 82,111 | -24,668 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 113,565 | 66,384 | -47,181 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 35,750 | +35,750 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CAXTON CORP | 18,403 | 18,403 | 0 | 0.12 | 0.08 | -0.04 | hold |
| XTX Topco Ltd | 0 | 10,597 | +10,597 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 167 | +167 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 113 | 117 | +4 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 17,067 | 0 | -17,067 | 0.00 | 0.00 | -0.00 | sell |
| LUMINUS MANAGEMENT LLC | 328,222 | 0 | -328,222 | 0.06 | 0.00 | -0.06 | sell |
| GTS SECURITIES LLC | 44,176 | 0 | -44,176 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 7,414 | 0 | -7,414 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 680,188 | 0 | -680,188 | 0.00 | 0.00 | -0.00 | sell |
| Newbridge Financial Services Group, Inc. | 2,000 | 0 | -2,000 | 0.00 | 0.00 | -0.00 | sell |