| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 0 | 2,601,216 | +2,601,216 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 35,750 | 2,593,198 | +2,557,448 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,495,031 | 3,785,909 | +290,878 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 320,127 | 508,329 | +188,202 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 10,597 | 101,605 | +91,008 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 52,701 | +52,701 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 46,220 | +46,220 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 28,921 | +28,921 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 7,407,906 | 7,432,906 | +25,000 | 2.23 | 3.37 | +1.14 | buy |
| NORTHERN TRUST CORP | 66,384 | 84,281 | +17,897 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 15,084 | +15,084 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 152,607 | 165,607 | +13,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 9,611 | +9,611 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 1,348 | +1,348 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 4,683,711 | 4,683,711 | 0 | 1.89 | 2.23 | +0.34 | hold |
| CAXTON CORP | 18,403 | 18,403 | 0 | 0.08 | 0.63 | +0.55 | hold |
| Blackstone Inc. | 2,440,330 | 2,440,330 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Alyeska Investment Group, L.P. | 1,663,355 | 1,663,355 | 0 | 0.00 | 0.01 | +0.00 | hold |
| HighTower Advisors, LLC | 125,852 | 125,852 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sio Capital Management, LLC | 1,341,636 | 1,341,636 | 0 | 0.33 | 0.33 | -0.00 | hold |
| Clear Harbor Asset Management, LLC | 92,804 | 92,804 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Cerity Partners LLC | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nextech Invest, Ltd. | 7,419,355 | 7,419,355 | 0 | 1.09 | 1.05 | -0.04 | hold |
| Walleye Capital LLC | 132,786 | 132,786 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Velan Capital Investment Management LP | 100,000 | 100,000 | 0 | 0.09 | 0.09 | -0.01 | hold |
| Deep Track Capital, LP | 7,419,355 | 7,419,355 | 0 | 0.20 | 0.25 | +0.05 | hold |
| ADAR1 Capital Management, LLC | 351,094 | 351,094 | 0 | 0.03 | 0.04 | +0.00 | hold |
| Mill Creek Capital Advisors, LLC | 104,631 | 104,631 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pathstone Holdings, LLC | 110,244 | 110,244 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 4,003,380 | 4,003,380 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 117 | 114 | -3 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 608,577 | 608,462 | -115 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 167 | 0 | -167 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 848,970 | 848,046 | -924 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 82,111 | 0 | -82,111 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 402,653 | 0 | -402,653 | 0.04 | 0.00 | -0.04 | sell |
| Nantahala Capital Management, LLC | 1,661,950 | 37,837 | -1,624,113 | 0.10 | 0.00 | -0.10 | sell |
| Avidity Partners Management LP | 8,981,855 | 5,504,855 | -3,477,000 | 1.98 | 2.33 | +0.35 | sell |
| MPM BioImpact LLC | 14,705,882 | 10,679,391 | -4,026,491 | 2.33 | 1.80 | -0.54 | sell |