| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 0 | 3,083,307 | +3,083,307 | 0.00 | 0.61 | +0.61 | buy |
| First Light Asset Management, LLC | 0 | 3,002,045 | +3,002,045 | 0.00 | 2.60 | +2.60 | buy |
| 5AM Venture Management, LLC | 0 | 1,245,000 | +1,245,000 | 0.00 | 3.15 | +3.15 | buy |
| MORGAN STANLEY | 1,214,050 | 2,137,365 | +923,315 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 289,381 | 1,104,014 | +814,633 | 0.03 | 0.12 | +0.10 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,539,464 | 2,958,079 | +418,615 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,840,482 | 2,257,718 | +417,236 | 0.04 | 0.07 | +0.03 | buy |
| Artal Group S.A. | 1,012,500 | 1,412,500 | +400,000 | 0.27 | 0.41 | +0.14 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 371,000 | +371,000 | 0.00 | 0.02 | +0.02 | buy |
| PFM Health Sciences, LP | 0 | 314,674 | +314,674 | 0.00 | 0.18 | +0.18 | buy |
| Exome Asset Management LLC | 0 | 274,900 | +274,900 | 0.00 | 2.66 | +2.66 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 254,446 | +254,446 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 42,487 | 287,393 | +244,906 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 231,565 | +231,565 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 206,856 | +206,856 | 0.00 | 0.64 | +0.64 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 381,083 | 485,174 | +104,091 | 0.12 | 0.22 | +0.10 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 90,240 | +90,240 | 0.00 | 0.09 | +0.09 | buy |
| ExodusPoint Capital Management, LP | 296,886 | 379,314 | +82,428 | 0.03 | 0.05 | +0.02 | buy |
| Trexquant Investment LP | 14,354 | 96,531 | +82,177 | 0.00 | 0.02 | +0.02 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 69,109 | +69,109 | 0.00 | 0.05 | +0.05 | buy |
| Cubist Systematic Strategies, LLC | 4,824 | 72,609 | +67,785 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 16,500 | 78,781 | +62,281 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 875,765 | 923,120 | +47,355 | 0.00 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,021 | 108,048 | +45,027 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 186,310 | 228,644 | +42,334 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,115,817 | 1,156,723 | +40,906 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 37,030 | 76,984 | +39,954 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 795,729 | 830,546 | +34,817 | 1.26 | 1.53 | +0.26 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 185,600 | 218,800 | +33,200 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 24,731 | 55,027 | +30,296 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 29,409 | +29,409 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 14,300 | 32,873 | +18,573 | 0.00 | 0.01 | +0.01 | buy |
| Lynx1 Capital Management LP | 0 | 17,400 | +17,400 | 0.00 | 0.05 | +0.05 | buy |
| JPMORGAN CHASE & CO | 10,630 | 27,265 | +16,635 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 13,587 | +13,587 | 0.00 | 0.01 | +0.01 | buy |
| EntryPoint Capital, LLC | 0 | 9,636 | +9,636 | 0.00 | 0.10 | +0.10 | buy |
| Qube Research & Technologies Ltd | 1,311 | 8,944 | +7,633 | 0.00 | 0.00 | +0.00 | buy |
| State of Tennessee, Department of Treasury | 0 | 5,798 | +5,798 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,394 | 10,817 | +4,423 | 0.01 | 0.02 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 2,267 | +2,267 | 0.00 | 0.00 | +0.00 | buy |
| Advisors Preferred, LLC | 0 | 1,825 | +1,825 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 567 | 1,498 | +931 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 6,000 | 6,500 | +500 | 0.02 | 0.03 | +0.01 | buy |
| GENERAL ATLANTIC, L.P. | 9,681,818 | 9,681,818 | 0 | 1.11 | 2.54 | +1.44 | hold |
| ADIRONDACK TRUST CO | 925 | 925 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 33,539 | 33,539 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rathbones Group PLC | 31,300 | 31,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 125,157 | 125,157 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 211 | 211 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cormorant Asset Management, LP | 561,600 | 561,600 | 0 | 0.21 | 0.28 | +0.07 | hold |
| EcoR1 Capital, LLC | 5,618,779 | 5,618,779 | 0 | 1.16 | 1.61 | +0.45 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 19,963,157 | 19,963,157 | 0 | 53.64 | 50.22 | -3.43 | hold |
| Global Retirement Partners, LLC | 700 | 700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vida Ventures Advisors, LLC | 3,931,818 | 3,931,818 | 0 | 37.26 | 24.68 | -12.58 | hold |
| Octagon Capital Advisors LP | 2,060,100 | 2,060,100 | 0 | 2.62 | 2.83 | +0.21 | hold |
| TCG Crossover Management, LLC | 2,040,816 | 2,040,816 | 0 | 1.80 | 1.82 | +0.02 | hold |
| Spire Wealth Management | 70 | 70 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tanager Wealth Management LLP | 696,096 | 696,096 | 0 | 1.01 | 1.27 | +0.26 | hold |
| FMR LLC | 2,787,194 | 2,787,194 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NBC SECURITIES, INC. | 138 | 138 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALDWELL SUTTER CAPITAL, INC. | 172 | 86 | -86 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 999 | 204 | -795 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,303 | 1,010 | -1,293 | 0.00 | 0.00 | +0.00 | sell |
| Compagnie Lombard Odier SCmA | 5,820 | 0 | -5,820 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 6,400 | 0 | -6,400 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 12,629 | 0 | -12,629 | 0.00 | 0.00 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 38,138 | 0 | -38,138 | 0.17 | 0.00 | -0.17 | sell |
| CITADEL ADVISORS LLC | 100,804 | 46,968 | -53,836 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 140,856 | 0 | -140,856 | 0.01 | 0.00 | -0.01 | sell |
| Kynam Capital Management, LP | 442,704 | 0 | -442,704 | 0.40 | 0.00 | -0.40 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,896,128 | 2,250,000 | -646,128 | 0.05 | 0.05 | +0.00 | sell |
| BVF INC/IL | 8,774,570 | 0 | -8,774,570 | 1.75 | 0.00 | -1.75 | sell |