| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,119,027 | 6,954,000 | +1,834,973 | 0.15 | 0.19 | +0.04 | buy |
| JANUS HENDERSON GROUP PLC | 4,909,487 | 5,922,486 | +1,012,999 | 0.04 | 0.05 | 0.00 | buy |
| Affinity Asset Advisors, LLC | 1,095,924 | 1,546,662 | +450,738 | 2.87 | 3.48 | +0.61 | buy |
| Cutter Capital Management, LP | 147,076 | 418,127 | +271,051 | 1.01 | 2.62 | +1.61 | buy |
| PFM Health Sciences, LP | 371,766 | 570,546 | +198,780 | 0.39 | 0.60 | +0.21 | buy |
| Commodore Capital LP | 2,218,425 | 2,367,578 | +149,153 | 2.72 | 2.51 | -0.21 | buy |
| Allostery Investments LP | 284,517 | 382,524 | +98,007 | 9.36 | 7.93 | -1.42 | buy |
| Blue Owl Capital Holdings LP | 220,000 | 315,000 | +95,000 | 0.85 | 1.46 | +0.61 | buy |
| HighMark Wealth Management LLC | 166,135 | 235,785 | +69,650 | 1.60 | 2.00 | +0.40 | buy |
| ADAR1 Capital Management, LLC | 154,027 | 216,166 | +62,139 | 0.53 | 0.60 | +0.07 | buy |
| Nantahala Capital Management, LLC | 512,647 | 554,803 | +42,156 | 0.37 | 0.32 | -0.05 | buy |
| DIADEMA PARTNERS LP | 131,862 | 164,048 | +32,186 | 2.49 | 1.88 | -0.60 | buy |
| LORD, ABBETT & CO. LLC | 440,495 | 446,196 | +5,701 | 0.02 | 0.02 | -0.00 | buy |
| Exome Asset Management LLC | 137,716 | 142,744 | +5,028 | 1.74 | 1.84 | +0.10 | buy |
| Shay Capital LLC | 14,269 | 16,269 | +2,000 | 0.04 | 0.03 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,872 | 2,283 | +411 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 37,701 | 37,720 | +19 | 0.55 | 0.48 | -0.07 | buy |
| Rathbones Group PLC | 16,650 | 16,500 | -150 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 18,909 | 18,311 | -598 | 0.03 | 0.02 | -0.01 | sell |
| Ally Bridge Group (NY) LLC | 244,538 | 243,086 | -1,452 | 3.51 | 3.15 | -0.36 | sell |
| HighVista Strategies LLC | 46,116 | 39,020 | -7,096 | 0.29 | 0.22 | -0.07 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,364,392 | 5,342,344 | -22,048 | 0.01 | 0.01 | -0.00 | sell |
| J. Goldman & Co LP | 164,703 | 136,674 | -28,029 | 0.07 | 0.05 | -0.02 | sell |
| FRED ALGER MANAGEMENT, LLC | 190,451 | 146,398 | -44,053 | 0.02 | 0.01 | -0.00 | sell |
| Siren, L.L.C. | 3,004,677 | 2,960,029 | -44,648 | 2.22 | 2.40 | +0.18 | sell |
| Artia Global Partners LP | 80,380 | 35,226 | -45,154 | 0.54 | 0.15 | -0.39 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 303,479 | 257,418 | -46,061 | 0.01 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 641,964 | 593,335 | -48,629 | 2.70 | 2.73 | +0.03 | sell |
| TD ASSET MANAGEMENT INC | 641,714 | 588,122 | -53,592 | 0.01 | 0.01 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 370,278 | 267,887 | -102,391 | 0.36 | 0.22 | -0.14 | sell |
| Woodline Partners LP | 545,645 | 400,278 | -145,367 | 0.06 | 0.04 | -0.02 | sell |
| Cormorant Asset Management, LP | 2,561,600 | 2,261,600 | -300,000 | 2.36 | 2.45 | +0.09 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 598,952 | 232,758 | -366,194 | 2.24 | 0.70 | -1.54 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,598,183 | 1,095,533 | -502,650 | 0.22 | 0.15 | -0.07 | sell |
| Octagon Capital Advisors LP | 1,993,052 | 1,425,000 | -568,052 | 5.68 | 4.03 | -1.65 | sell |
| Avidity Partners Management LP | 1,165,800 | 529,000 | -636,800 | 1.95 | 1.57 | -0.38 | sell |
| First Light Asset Management, LLC | 5,805,184 | 4,874,124 | -931,060 | 9.30 | 8.00 | -1.30 | sell |
| T. Rowe Price Investment Management, Inc. | 3,418,600 | 1,753,248 | -1,665,352 | 0.04 | 0.02 | -0.02 | sell |
| PERCEPTIVE ADVISORS LLC | 6,349,220 | 3,040,395 | -3,308,825 | 2.93 | 1.54 | -1.39 | sell |