| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 0 | 4,050,000 | +4,050,000 | 0.00 | 0.91 | +0.91 | buy |
| Holocene Advisors, LP | 0 | 2,255,679 | +2,255,679 | 0.00 | 0.10 | +0.10 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,119,027 | 6,954,000 | +1,834,973 | 0.15 | 0.19 | +0.04 | buy |
| JANUS HENDERSON GROUP PLC | 4,909,487 | 5,922,486 | +1,012,999 | 0.04 | 0.05 | +0.01 | buy |
| MORGAN STANLEY | 1,924,509 | 2,937,467 | +1,012,958 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,746 | 899,505 | +883,759 | 0.00 | 0.02 | +0.02 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 3,498,709 | 4,334,318 | +835,609 | 0.31 | 0.34 | +0.03 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 468,000 | +468,000 | 0.00 | 0.18 | +0.18 | buy |
| Affinity Asset Advisors, LLC | 1,095,924 | 1,546,662 | +450,738 | 2.87 | 3.48 | +0.61 | buy |
| Saturn V Capital Management LP | 0 | 448,692 | +448,692 | 0.00 | 3.26 | +3.26 | buy |
| Ensign Peak Advisors, Inc | 79,000 | 438,133 | +359,133 | 0.00 | 0.01 | +0.01 | buy |
| Wildcat Capital Management, LLC | 0 | 281,859 | +281,859 | 0.00 | 2.16 | +2.16 | buy |
| Cutter Capital Management, LP | 147,076 | 418,127 | +271,051 | 1.01 | 2.62 | +1.61 | buy |
| FRANKLIN RESOURCES INC | 2,308,546 | 2,541,999 | +233,453 | 0.01 | 0.01 | -0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 227,598 | +227,598 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 175,566 | 401,764 | +226,198 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 398,451 | 609,188 | +210,737 | 0.01 | 0.01 | +0.00 | buy |
| PFM Health Sciences, LP | 371,766 | 570,546 | +198,780 | 0.47 | 0.63 | +0.15 | buy |
| FMR LLC | 3,651,594 | 3,826,194 | +174,600 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 43,708 | 207,028 | +163,320 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 151,296 | +151,296 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 149,702 | +149,702 | 0.00 | 1.17 | +1.17 | buy |
| Commodore Capital LP | 2,218,425 | 2,367,578 | +149,153 | 2.72 | 2.51 | -0.21 | buy |
| Windmill Hill Asset Management Ltd | 0 | 117,913 | +117,913 | 0.00 | 0.52 | +0.52 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 105,925 | +105,925 | 0.00 | 0.01 | +0.01 | buy |
| Allostery Investments LP | 284,517 | 382,524 | +98,007 | 9.36 | 7.93 | -1.42 | buy |
| Blue Owl Capital Holdings LP | 220,000 | 315,000 | +95,000 | 0.85 | 1.46 | +0.61 | buy |
| OAKMONT Corp | 0 | 92,064 | +92,064 | 0.00 | 0.26 | +0.26 | buy |
| Aberdeen Group plc | 0 | 90,883 | +90,883 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 82,199 | +82,199 | 0.00 | 0.01 | +0.01 | buy |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 0 | 81,884 | +81,884 | 0.00 | 0.25 | +0.25 | buy |
| CITADEL ADVISORS LLC | 625,316 | 706,331 | +81,015 | 0.01 | 0.01 | +0.00 | buy |
| HighMark Wealth Management LLC | 166,135 | 235,785 | +69,650 | 1.60 | 2.00 | +0.40 | buy |
| ADAR1 Capital Management, LLC | 154,027 | 216,166 | +62,139 | 0.53 | 0.60 | +0.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| Ellsworth Advisors, LLC | 0 | 48,872 | +48,872 | 0.00 | 0.18 | +0.18 | buy |
| Nantahala Capital Management, LLC | 512,647 | 554,803 | +42,156 | 0.60 | 0.66 | +0.06 | buy |
| BARCLAYS PLC | 5,302 | 38,174 | +32,872 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 32,754 | +32,754 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 131,862 | 164,048 | +32,186 | 2.49 | 1.88 | -0.60 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 31,446 | +31,446 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 115,107 | 138,767 | +23,660 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 21,917 | +21,917 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 19,122 | 40,868 | +21,746 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 22,680 | 41,057 | +18,377 | 0.03 | 0.03 | -0.00 | buy |
| Squarepoint Ops LLC | 26,806 | 42,862 | +16,056 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 15,785 | +15,785 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 14,888 | +14,888 | 0.00 | 0.02 | +0.02 | buy |
| Graham Capital Management, L.P. | 0 | 14,617 | +14,617 | 0.00 | 0.01 | +0.01 | buy |
| OneAscent Financial Services LLC | 0 | 13,216 | +13,216 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,079,708 | 1,092,754 | +13,046 | 0.01 | 0.01 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 12,090 | +12,090 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 11,111 | +11,111 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 0 | 10,257 | +10,257 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 9,733 | +9,733 | 0.00 | 0.04 | +0.04 | buy |
| Verition Fund Management LLC | 36,195 | 42,437 | +6,242 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 440,495 | 446,196 | +5,701 | 0.02 | 0.02 | -0.00 | buy |
| Exome Asset Management LLC | 137,716 | 142,744 | +5,028 | 1.74 | 1.84 | +0.10 | buy |
| Caitong International Asset Management Co., Ltd | 21 | 3,215 | +3,194 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 57,257 | 60,441 | +3,184 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 261,184 | 263,994 | +2,810 | 0.05 | 0.04 | -0.01 | buy |
| Shay Capital LLC | 14,269 | 16,269 | +2,000 | 0.06 | 0.07 | +0.01 | buy |
| Legal & General Group Plc | 75,451 | 76,051 | +600 | 0.00 | 0.00 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 73,189 | 73,718 | +529 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 3,837 | 4,295 | +458 | 0.01 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,872 | 2,283 | +411 | 0.00 | 0.00 | +0.00 | buy |
| Washington Trust Advisors, Inc. | 0 | 184 | +184 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,179 | 1,330 | +151 | 0.00 | 0.00 | -0.00 | buy |
| NBC SECURITIES, INC. | 0 | 138 | +138 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,972 | 3,055 | +83 | 0.00 | 0.00 | -0.00 | buy |
| BELLEVUE ASSET MANAGEMENT, LLC | 0 | 70 | +70 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 37,701 | 37,720 | +19 | 0.55 | 0.48 | -0.07 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GENERAL ATLANTIC, L.P. | 9,681,818 | 9,681,818 | 0 | 5.77 | 4.67 | -1.10 | hold |
| ADIRONDACK TRUST CO | 925 | 925 | 0 | 0.01 | 0.01 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 29,670 | 29,670 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,227,178 | 1,227,178 | 0 | 0.22 | 0.20 | -0.02 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 35,800 | 35,800 | 0 | 0.05 | 0.05 | +0.00 | hold |
| Daiwa Securities Group Inc. | 294 | 294 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 50,000 | 50,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 41,900 | 41,900 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Harbour Capital Advisors, LLC | 16,375 | 16,375 | 0 | 0.06 | 0.05 | -0.01 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 19,963,157 | 19,963,157 | 0 | 63.20 | 65.59 | +2.38 | hold |
| 5AM Venture Management, LLC | 830,945 | 830,945 | 0 | 3.32 | 4.52 | +1.20 | hold |
| TCG Crossover Management, LLC | 2,890,816 | 2,890,816 | 0 | 4.73 | 5.67 | +0.94 | hold |
| Index Venture Life Associates VI Ltd | 9,961,789 | 9,961,789 | 0 | 99.89 | 100.00 | +0.11 | hold |
| Bell Investment Advisors, Inc | 31 | 31 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tanager Wealth Management LLP | 696,096 | 696,096 | 0 | 1.51 | 1.30 | -0.21 | hold |
| Foresite Capital Management VI LLC | 1,253,379 | 1,253,379 | 0 | 9.35 | 9.87 | +0.52 | hold |
| CALDWELL SUTTER CAPITAL, INC. | 43 | 43 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 600 | 600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 16,650 | 16,500 | -150 | 0.00 | 0.00 | -0.00 | sell |
| Atria Investments, Inc | 13,774 | 13,547 | -227 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 18,909 | 18,311 | -598 | 0.03 | 0.02 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 178,600 | 178,000 | -600 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,861 | 919 | -942 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 990 | 0 | -990 | 0.02 | 0.00 | -0.02 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,813 | 755 | -1,058 | 0.00 | 0.00 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 244,538 | 243,086 | -1,452 | 3.51 | 3.15 | -0.36 | sell |