| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Pentwater Capital Management LP | 0 | 8,170,000 | +8,170,000 | 0.00 | 2.31 | +2.31 | buy |
| Capital World Investors | 1,158,699 | 4,832,548 | +3,673,849 | 0.00 | 0.03 | +0.02 | buy |
| Paradigm Biocapital Advisors LP | 0 | 3,574,048 | +3,574,048 | 0.00 | 2.90 | +2.90 | buy |
| MORGAN STANLEY | 1,109,098 | 4,268,353 | +3,159,255 | 0.00 | 0.01 | +0.01 | buy |
| EcoR1 Capital, LLC | 3,115,000 | 6,000,000 | +2,885,000 | 3.56 | 10.18 | +6.63 | buy |
| PERCEPTIVE ADVISORS LLC | 2,917,634 | 5,258,903 | +2,341,269 | 1.34 | 4.13 | +2.79 | buy |
| Logos Global Management LP | 200,000 | 2,125,000 | +1,925,000 | 0.33 | 4.35 | +4.01 | buy |
| Deep Track Capital, LP | 2,000,000 | 3,158,041 | +1,158,041 | 1.14 | 2.59 | +1.45 | buy |
| BANK OF AMERICA CORP /DE/ | 949,544 | 1,932,406 | +982,862 | 0.00 | 0.01 | +0.00 | buy |
| ALPINE ASSOCIATES MANAGEMENT INC. | 0 | 865,500 | +865,500 | 0.00 | 2.03 | +2.03 | buy |
| Affinity Asset Advisors, LLC | 600,552 | 1,400,000 | +799,448 | 1.08 | 3.26 | +2.18 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 702,254 | +702,254 | 0.00 | 0.03 | +0.03 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 668,142 | +668,142 | 0.00 | 0.44 | +0.44 | buy |
| TIG Advisors, LLC | 0 | 648,326 | +648,326 | 0.00 | 1.23 | +1.23 | buy |
| Bain Capital Life Sciences Investors, LLC | 0 | 635,000 | +635,000 | 0.00 | 2.27 | +2.27 | buy |
| TORONTO DOMINION BANK | 0 | 534,700 | +534,700 | 0.00 | 0.04 | +0.04 | buy |
| Weiss Asset Management LP | 0 | 510,407 | +510,407 | 0.00 | 0.37 | +0.37 | buy |
| JPMORGAN CHASE & CO | 81,486 | 477,597 | +396,111 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 468,815 | 852,828 | +384,013 | 0.02 | 0.07 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 779,001 | 1,144,560 | +365,559 | 0.00 | 0.01 | +0.00 | buy |
| GLAZER CAPITAL, LLC | 0 | 325,001 | +325,001 | 0.00 | 0.27 | +0.27 | buy |
| Alyeska Investment Group, L.P. | 0 | 320,430 | +320,430 | 0.00 | 0.04 | +0.04 | buy |
| Point72 Asset Management, L.P. | 0 | 307,355 | +307,355 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 578,251 | 859,105 | +280,854 | 0.06 | 0.13 | +0.07 | buy |
| Caption Management, LLC | 0 | 274,116 | +274,116 | 0.00 | 0.52 | +0.52 | buy |
| RTW INVESTMENTS, LP | 1,790,837 | 2,054,175 | +263,338 | 0.45 | 0.81 | +0.36 | buy |
| Qube Research & Technologies Ltd | 378,740 | 628,049 | +249,309 | 0.01 | 0.04 | +0.02 | buy |
| Trexquant Investment LP | 146,523 | 390,951 | +244,428 | 0.03 | 0.11 | +0.08 | buy |
| MAVERICK CAPITAL LTD | 1,643,724 | 1,854,488 | +210,764 | 0.44 | 0.86 | +0.42 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 171,933 | +171,933 | 0.00 | 0.06 | +0.06 | buy |
| T. Rowe Price Investment Management, Inc. | 1,536 | 170,016 | +168,480 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 18,347 | 158,509 | +140,162 | 0.04 | 0.45 | +0.41 | buy |
| LMR Partners LLP | 0 | 125,000 | +125,000 | 0.00 | 0.05 | +0.05 | buy |
| TORONTO DOMINION BANK | 0 | 120,150 | +120,150 | 0.00 | 0.01 | +0.01 | buy |
| Eagle Health Investments LP | 103,100 | 214,291 | +111,191 | 0.57 | 1.79 | +1.22 | buy |
| Freestone Grove Partners LP | 0 | 109,327 | +109,327 | 0.00 | 0.03 | +0.03 | buy |
| HRT FINANCIAL LP | 11,020 | 116,992 | +105,972 | 0.00 | 0.01 | +0.01 | buy |
| AQR Arbitrage LLC | 0 | 98,028 | +98,028 | 0.00 | 0.06 | +0.06 | buy |
| Pictet Asset Management Holding SA | 0 | 96,910 | +96,910 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 3,218 | 93,685 | +90,467 | 0.02 | 0.69 | +0.67 | buy |
| Y-Intercept (Hong Kong) Ltd | 11,441 | 96,367 | +84,926 | 0.01 | 0.07 | +0.07 | buy |
| HARVEST MANAGEMENT LLC | 0 | 80,000 | +80,000 | 0.00 | 1.69 | +1.69 | buy |
| CITADEL ADVISORS LLC | 519,962 | 598,197 | +78,235 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 2,691 | 74,276 | +71,585 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 67,775 | +67,775 | 0.00 | 0.11 | +0.11 | buy |
| Holocene Advisors, LP | 101,597 | 160,942 | +59,345 | 0.01 | 0.02 | +0.01 | buy |
| WATER ISLAND CAPITAL LLC | 0 | 41,000 | +41,000 | 0.00 | 0.22 | +0.22 | buy |
| Knott David M Jr | 4,000 | 39,000 | +35,000 | 0.05 | 0.92 | +0.88 | buy |
| DEUTSCHE BANK AG\ | 156,205 | 189,961 | +33,756 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 592,604 | 625,420 | +32,816 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 324,015 | 351,828 | +27,813 | 0.42 | 0.82 | +0.41 | buy |
| Yakira Capital Management, Inc. | 0 | 24,000 | +24,000 | 0.00 | 0.28 | +0.28 | buy |
| JBF Capital, Inc. | 0 | 20,887 | +20,887 | 0.00 | 0.12 | +0.12 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 87,610 | 107,778 | +20,168 | 0.00 | 0.00 | +0.00 | buy |
| Fortress Investment Group LLC | 0 | 20,000 | +20,000 | 0.00 | 0.20 | +0.20 | buy |
| TORNO CAPITAL, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.33 | +0.33 | buy |
| Crossmark Global Holdings, Inc. | 0 | 19,436 | +19,436 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 18,113 | +18,113 | 0.00 | 0.10 | +0.10 | buy |
| GABELLI FUNDS LLC | 0 | 17,600 | +17,600 | 0.00 | 0.00 | +0.00 | buy |
| CSS LLC/IL | 0 | 17,000 | +17,000 | 0.00 | 0.04 | +0.04 | buy |
| Greenland Capital Management LP | 0 | 15,000 | +15,000 | 0.00 | 0.12 | +0.12 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 14,913 | +14,913 | 0.00 | 0.07 | +0.07 | buy |
| TD Waterhouse Canada Inc. | 1,003 | 15,595 | +14,592 | 0.00 | 0.00 | +0.00 | buy |
| GABELLI & Co INVESTMENT ADVISERS, INC. | 0 | 9,400 | +9,400 | 0.00 | 0.06 | +0.06 | buy |
| Bellevue Group AG | 0 | 9,030 | +9,030 | 0.00 | 0.01 | +0.01 | buy |
| Rangeley Capital, LLC | 0 | 9,000 | +9,000 | 0.00 | 0.39 | +0.39 | buy |
| AXQ CAPITAL, LP | 0 | 8,303 | +8,303 | 0.00 | 0.04 | +0.04 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 458,203 | 466,345 | +8,142 | 1.66 | 2.18 | +0.52 | buy |
| Brooklyn Investment Group | 0 | 7,443 | +7,443 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 32,508 | 39,656 | +7,148 | 0.02 | 0.04 | +0.02 | buy |
| Invesco Ltd. | 0 | 7,034 | +7,034 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 6,991 | +6,991 | 0.00 | 0.03 | +0.03 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 6,975 | +6,975 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 6,900 | +6,900 | 0.00 | 0.00 | +0.00 | buy |
| BBR PARTNERS, LLC | 0 | 6,551 | +6,551 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,563 | 17,737 | +6,174 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 162,147 | 168,170 | +6,023 | 0.02 | 0.03 | +0.01 | buy |
| Private Advisor Group, LLC | 0 | 6,000 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 6,000 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,108 | 6,922 | +5,814 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 15,721 | 21,225 | +5,504 | 0.03 | 0.06 | +0.03 | buy |
| ProShare Advisors LLC | 0 | 5,351 | +5,351 | 0.00 | 0.00 | +0.00 | buy |
| Empirical Asset Management, LLC | 0 | 5,083 | +5,083 | 0.00 | 0.05 | +0.05 | buy |
| Legal & General Group Plc | 105,427 | 110,207 | +4,780 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 57,444 | 59,844 | +2,400 | 0.00 | 0.00 | -0.00 | buy |
| Bayforest Capital Ltd | 0 | 1,947 | +1,947 | 0.00 | 0.09 | +0.09 | buy |
| Mirae Asset Global Investments Co., Ltd. | 4,688 | 6,238 | +1,550 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 3,615 | 3,980 | +365 | 0.00 | 0.01 | +0.00 | buy |
| J.Safra Asset Management Corp | 99 | 397 | +298 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 277 | +277 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,895 | 2,166 | +271 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 10,034 | 10,286 | +252 | 0.07 | 0.11 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,446 | 2,482 | +36 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| SJS Investment Consulting Inc. | 15 | 22 | +7 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 7 | 12 | +5 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 25 | 30 | +5 | 0.00 | 0.00 | +0.00 | buy |
| ADIRONDACK TRUST CO | 925 | 925 | 0 | 0.01 | 0.01 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 29,670 | 29,670 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 670,751 | 670,751 | 0 | 0.10 | 0.15 | +0.05 | hold |