| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Medicxi Ventures Management (Jersey) Ltd | 19,963,157 | 19,963,157 | 0 | 59.80 | 80.76 | +20.97 | hold |
| Avoro Capital Advisors LLC | 14,555,555 | 11,430,455 | -3,125,100 | 3.58 | 4.47 | +0.89 | sell |
| Index Venture Life Associates VI Ltd | 9,961,789 | 9,961,789 | 0 | 100.00 | 100.00 | 0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 11,281,741 | 8,925,010 | -2,356,731 | 0.43 | 0.55 | +0.12 | sell |
| Pentwater Capital Management LP | 0 | 8,170,000 | +8,170,000 | 0.00 | 2.31 | +2.31 | buy |
| FMR LLC | 8,961,939 | 6,852,047 | -2,109,892 | 0.01 | 0.01 | +0.00 | sell |
| EcoR1 Capital, LLC | 3,115,000 | 6,000,000 | +2,885,000 | 3.56 | 10.18 | +6.63 | buy |
| PERCEPTIVE ADVISORS LLC | 2,917,634 | 5,258,903 | +2,341,269 | 1.34 | 4.13 | +2.79 | buy |
| Capital World Investors | 1,158,699 | 4,832,548 | +3,673,849 | 0.00 | 0.03 | +0.02 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 5,377,068 | 4,809,000 | -568,068 | 0.70 | 1.13 | +0.43 | sell |
| TCG Crossover Management, LLC | 4,286,480 | 4,286,480 | 0 | 3.55 | 4.87 | +1.32 | hold |
| MORGAN STANLEY | 1,109,098 | 4,268,353 | +3,159,255 | 0.00 | 0.01 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 0 | 3,574,048 | +3,574,048 | 0.00 | 2.90 | +2.90 | buy |
| JANUS HENDERSON GROUP PLC | 4,093,608 | 3,492,977 | -600,631 | 0.05 | 0.07 | +0.02 | sell |
| Deep Track Capital, LP | 2,000,000 | 3,158,041 | +1,158,041 | 1.14 | 2.59 | +1.45 | buy |
| Logos Global Management LP | 200,000 | 2,125,000 | +1,925,000 | 0.33 | 4.35 | +4.01 | buy |
| RTW INVESTMENTS, LP | 1,790,837 | 2,054,175 | +263,338 | 0.45 | 0.81 | +0.36 | buy |
| FEDERATED HERMES, INC. | 2,342,139 | 2,049,439 | -292,700 | 0.10 | 0.13 | +0.03 | sell |
| BRAIDWELL LP | 2,188,320 | 1,986,768 | -201,552 | 1.75 | 2.63 | +0.88 | sell |
| BANK OF AMERICA CORP /DE/ | 949,544 | 1,932,406 | +982,862 | 0.00 | 0.01 | +0.00 | buy |
| MAVERICK CAPITAL LTD | 1,643,724 | 1,854,488 | +210,764 | 0.44 | 0.86 | +0.42 | buy |
| First Light Asset Management, LLC | 2,278,940 | 1,560,991 | -717,949 | 4.36 | 5.56 | +1.20 | sell |
| Affinity Asset Advisors, LLC | 600,552 | 1,400,000 | +799,448 | 1.08 | 3.26 | +2.18 | buy |
| Foresite Capital Management VI LLC | 1,364,019 | 1,364,019 | 0 | 10.31 | 11.77 | +1.46 | hold |
| GENERAL ATLANTIC, L.P. | 6,117,715 | 1,354,830 | -4,762,885 | 5.33 | 2.50 | -2.82 | sell |
| GOLDMAN SACHS GROUP INC | 779,001 | 1,144,560 | +365,559 | 0.00 | 0.01 | +0.00 | buy |
| Siren, L.L.C. | 4,027,517 | 1,053,464 | -2,974,053 | 3.00 | 1.16 | -1.84 | sell |
| Cormorant Asset Management, LP | 1,325,000 | 1,050,000 | -275,000 | 1.88 | 2.10 | +0.22 | sell |
| ALPINE ASSOCIATES MANAGEMENT INC. | 0 | 865,500 | +865,500 | 0.00 | 2.03 | +2.03 | buy |
| Woodline Partners LP | 578,251 | 859,105 | +280,854 | 0.06 | 0.13 | +0.07 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 468,815 | 852,828 | +384,013 | 0.02 | 0.07 | +0.04 | buy |
| Octagon Capital Advisors LP | 750,000 | 750,000 | 0 | 2.35 | 3.30 | +0.95 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,870,671 | 722,121 | -1,148,550 | 0.03 | 0.02 | -0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 0 | 702,254 | +702,254 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,129,758 | 687,427 | -442,331 | 0.01 | 0.01 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 2,368,381 | 684,482 | -1,683,899 | 0.01 | 0.01 | -0.01 | sell |
| BAKER BROS. ADVISORS LP | 670,751 | 670,751 | 0 | 0.10 | 0.15 | +0.05 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 668,142 | +668,142 | 0.00 | 0.44 | +0.44 | buy |
| TIG Advisors, LLC | 0 | 648,326 | +648,326 | 0.00 | 1.23 | +1.23 | buy |
| D. E. Shaw & Co., Inc. | 831,636 | 643,808 | -187,828 | 0.02 | 0.02 | +0.00 | sell |
| Bain Capital Life Sciences Investors, LLC | 0 | 635,000 | +635,000 | 0.00 | 2.27 | +2.27 | buy |
| Qube Research & Technologies Ltd | 378,740 | 628,049 | +249,309 | 0.01 | 0.04 | +0.02 | buy |
| BlackRock, Inc. | 592,604 | 625,420 | +32,816 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 519,962 | 598,197 | +78,235 | 0.01 | 0.02 | +0.01 | buy |
| 5AM Venture Management, LLC | 580,945 | 580,945 | 0 | 4.57 | 6.41 | +1.84 | hold |
| TORONTO DOMINION BANK | 0 | 534,700 | +534,700 | 0.00 | 0.04 | +0.04 | buy |
| PFM Health Sciences, LP | 591,601 | 528,224 | -63,377 | 1.50 | 2.21 | +0.71 | sell |
| Weiss Asset Management LP | 0 | 510,407 | +510,407 | 0.00 | 0.37 | +0.37 | buy |
| JPMORGAN CHASE & CO | 81,486 | 477,597 | +396,111 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 458,203 | 466,345 | +8,142 | 1.66 | 2.18 | +0.52 | buy |
| Trexquant Investment LP | 146,523 | 390,951 | +244,428 | 0.03 | 0.11 | +0.08 | buy |
| UBS Group AG | 537,518 | 359,939 | -177,579 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 324,015 | 351,828 | +27,813 | 0.42 | 0.82 | +0.41 | buy |
| GLAZER CAPITAL, LLC | 0 | 325,001 | +325,001 | 0.00 | 0.27 | +0.27 | buy |
| Alyeska Investment Group, L.P. | 0 | 320,430 | +320,430 | 0.00 | 0.04 | +0.04 | buy |
| Point72 Asset Management, L.P. | 0 | 307,355 | +307,355 | 0.00 | 0.02 | +0.02 | buy |
| ROYCE & ASSOCIATES LP | 362,873 | 278,064 | -84,809 | 0.09 | 0.11 | +0.02 | sell |
| Caption Management, LLC | 0 | 274,116 | +274,116 | 0.00 | 0.52 | +0.52 | buy |
| Nantahala Capital Management, LLC | 254,803 | 254,803 | 0 | 0.38 | 0.63 | +0.25 | hold |
| TD ASSET MANAGEMENT INC | 376,344 | 242,044 | -134,300 | 0.01 | 0.01 | +0.00 | sell |
| HighMark Wealth Management LLC | 236,785 | 236,785 | 0 | 2.41 | 3.83 | +1.42 | hold |
| Eagle Health Investments LP | 103,100 | 214,291 | +111,191 | 0.57 | 1.79 | +1.22 | buy |
| SummitTX Capital, L.P. | 332,708 | 206,847 | -125,861 | 0.25 | 0.26 | +0.01 | sell |
| DEUTSCHE BANK AG\ | 156,205 | 189,961 | +33,756 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 279,300 | 185,000 | -94,300 | 0.01 | 0.01 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 171,933 | +171,933 | 0.00 | 0.06 | +0.06 | buy |
| T. Rowe Price Investment Management, Inc. | 1,536 | 170,016 | +168,480 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 216,130 | 168,177 | -47,953 | 0.01 | 0.01 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 162,147 | 168,170 | +6,023 | 0.02 | 0.03 | +0.01 | buy |
| Holocene Advisors, LP | 101,597 | 160,942 | +59,345 | 0.01 | 0.02 | +0.01 | buy |
| Atom Investors LP | 18,347 | 158,509 | +140,162 | 0.04 | 0.45 | +0.41 | buy |
| Burkehill Global Management, LP | 150,000 | 150,000 | 0 | 0.25 | 0.30 | +0.05 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 155,101 | 137,741 | -17,360 | 0.90 | 1.38 | +0.48 | sell |
| LMR Partners LLP | 0 | 125,000 | +125,000 | 0.00 | 0.05 | +0.05 | buy |
| TORONTO DOMINION BANK | 0 | 120,150 | +120,150 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 11,020 | 116,992 | +105,972 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 348,279 | 111,956 | -236,323 | 0.03 | 0.02 | -0.01 | sell |
| Legal & General Group Plc | 105,427 | 110,207 | +4,780 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Grove Partners LP | 0 | 109,327 | +109,327 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 87,610 | 107,778 | +20,168 | 0.00 | 0.00 | +0.00 | buy |
| AQR Arbitrage LLC | 0 | 98,028 | +98,028 | 0.00 | 0.06 | +0.06 | buy |
| Pictet Asset Management Holding SA | 0 | 96,910 | +96,910 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 11,441 | 96,367 | +84,926 | 0.01 | 0.07 | +0.07 | buy |
| Caitong International Asset Management Co., Ltd | 3,218 | 93,685 | +90,467 | 0.02 | 0.69 | +0.67 | buy |
| HARVEST MANAGEMENT LLC | 0 | 80,000 | +80,000 | 0.00 | 1.69 | +1.69 | buy |
| CITIGROUP INC | 2,691 | 74,276 | +71,585 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 915,803 | 71,513 | -844,290 | 0.22 | 0.04 | -0.19 | sell |
| Virtu Financial LLC | 0 | 67,775 | +67,775 | 0.00 | 0.11 | +0.11 | buy |
| TWO SIGMA INVESTMENTS, LP | 57,444 | 59,844 | +2,400 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 81,812 | 50,606 | -31,206 | 0.00 | 0.00 | +0.00 | sell |
| WATER ISLAND CAPITAL LLC | 0 | 41,000 | +41,000 | 0.00 | 0.22 | +0.22 | buy |
| JANE STREET GROUP, LLC | 480,204 | 40,968 | -439,236 | 0.01 | 0.00 | -0.01 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 32,508 | 39,656 | +7,148 | 0.02 | 0.04 | +0.02 | buy |
| Knott David M Jr | 4,000 | 39,000 | +35,000 | 0.05 | 0.92 | +0.88 | buy |
| Russell Investments Group, Ltd. | 74,819 | 38,812 | -36,007 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 38,566 | 38,566 | 0 | 0.07 | 0.09 | +0.02 | hold |
| Candriam S.C.A. | 395,623 | 36,254 | -359,369 | 0.05 | 0.01 | -0.04 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 29,670 | 29,670 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cinctive Capital Management LP | 72,831 | 25,350 | -47,481 | 0.11 | 0.07 | -0.04 | sell |
| Voleon Capital Management LP | 79,074 | 24,174 | -54,900 | 0.04 | 0.02 | -0.02 | sell |