| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 1,158,699 | 4,832,548 | +3,673,849 | 0.00 | 0.03 | +0.02 | buy |
| EcoR1 Capital, LLC | 3,115,000 | 6,000,000 | +2,885,000 | 3.56 | 10.18 | +6.63 | buy |
| PERCEPTIVE ADVISORS LLC | 2,917,634 | 5,258,903 | +2,341,269 | 1.34 | 4.13 | +2.79 | buy |
| Logos Global Management LP | 200,000 | 2,125,000 | +1,925,000 | 0.33 | 4.35 | +4.01 | buy |
| Deep Track Capital, LP | 2,000,000 | 3,158,041 | +1,158,041 | 1.14 | 2.59 | +1.45 | buy |
| Affinity Asset Advisors, LLC | 600,552 | 1,400,000 | +799,448 | 1.08 | 3.26 | +2.18 | buy |
| RTW INVESTMENTS, LP | 1,790,837 | 2,054,175 | +263,338 | 0.45 | 0.81 | +0.36 | buy |
| T. Rowe Price Investment Management, Inc. | 1,536 | 170,016 | +168,480 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 18,347 | 158,509 | +140,162 | 0.04 | 0.45 | +0.41 | buy |
| Eagle Health Investments LP | 103,100 | 214,291 | +111,191 | 0.57 | 1.79 | +1.22 | buy |
| Holocene Advisors, LP | 101,597 | 160,942 | +59,345 | 0.01 | 0.02 | +0.01 | buy |
| Knott David M Jr | 4,000 | 39,000 | +35,000 | 0.05 | 0.92 | +0.88 | buy |
| Rock Springs Capital Management LP | 324,015 | 351,828 | +27,813 | 0.42 | 0.82 | +0.41 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 458,203 | 466,345 | +8,142 | 1.66 | 2.18 | +0.52 | buy |
| J.Safra Asset Management Corp | 99 | 397 | +298 | 0.00 | 0.00 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 14,033 | 13,102 | -931 | 0.03 | 0.04 | +0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 155,101 | 137,741 | -17,360 | 0.90 | 1.38 | +0.48 | sell |
| HighVista Strategies LLC | 44,490 | 5,964 | -38,526 | 0.29 | 0.07 | -0.22 | sell |
| Cinctive Capital Management LP | 72,831 | 25,350 | -47,481 | 0.11 | 0.07 | -0.04 | sell |
| Voleon Capital Management LP | 79,074 | 24,174 | -54,900 | 0.04 | 0.02 | -0.02 | sell |
| PFM Health Sciences, LP | 591,601 | 528,224 | -63,377 | 1.50 | 2.21 | +0.71 | sell |
| SummitTX Capital, L.P. | 332,708 | 206,847 | -125,861 | 0.25 | 0.26 | +0.01 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 348,279 | 111,956 | -236,323 | 0.03 | 0.02 | -0.01 | sell |
| Cormorant Asset Management, LP | 1,325,000 | 1,050,000 | -275,000 | 1.88 | 2.10 | +0.22 | sell |
| Candriam S.C.A. | 395,623 | 36,254 | -359,369 | 0.05 | 0.01 | -0.04 | sell |
| First Light Asset Management, LLC | 2,278,940 | 1,560,991 | -717,949 | 4.36 | 5.56 | +1.20 | sell |
| Avoro Capital Advisors LLC | 14,555,555 | 11,430,455 | -3,125,100 | 3.58 | 4.47 | +0.89 | sell |
| GENERAL ATLANTIC, L.P. | 6,117,715 | 1,354,830 | -4,762,885 | 5.33 | 2.50 | -2.82 | sell |