| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| First Light Asset Management, LLC | 3,002,045 | 4,780,560 | +1,778,515 | 2.60 | 3.78 | +1.19 | buy |
| Cormorant Asset Management, LP | 561,600 | 1,611,600 | +1,050,000 | 0.28 | 0.84 | +0.56 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,104,014 | 2,092,011 | +987,997 | 0.12 | 0.18 | +0.06 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,250,000 | 3,125,000 | +875,000 | 0.05 | 0.05 | +0.00 | buy |
| TCG Crossover Management, LLC | 2,040,816 | 2,890,816 | +850,000 | 1.82 | 2.72 | +0.90 | buy |
| PERCEPTIVE ADVISORS LLC | 3,083,307 | 3,933,307 | +850,000 | 0.61 | 0.86 | +0.25 | buy |
| Artal Group S.A. | 1,412,500 | 2,112,500 | +700,000 | 0.41 | 0.49 | +0.08 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,958,079 | 3,530,373 | +572,294 | 0.00 | 0.00 | -0.00 | buy |
| PFM Health Sciences, LP | 314,674 | 635,643 | +320,969 | 0.17 | 0.28 | +0.12 | buy |
| Affinity Asset Advisors, LLC | 830,546 | 1,135,702 | +305,156 | 1.53 | 1.62 | +0.09 | buy |
| Octagon Capital Advisors LP | 2,060,100 | 2,345,075 | +284,975 | 2.83 | 3.49 | +0.66 | buy |
| EcoR1 Capital, LLC | 5,618,779 | 5,714,404 | +95,625 | 1.61 | 1.58 | -0.03 | buy |
| TD ASSET MANAGEMENT INC | 228,644 | 321,168 | +92,524 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 206,856 | 253,197 | +46,341 | 0.64 | 0.46 | -0.18 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 485,174 | 495,895 | +10,721 | 0.22 | 0.18 | -0.04 | buy |
| Quarry LP | 6,500 | 9,608 | +3,108 | 0.03 | 0.04 | 0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 69,109 | 68,900 | -209 | 0.05 | 0.05 | -0.00 | sell |
| EntryPoint Capital, LLC | 9,636 | 8,136 | -1,500 | 0.10 | 0.11 | +0.01 | sell |
| China Universal Asset Management Co., Ltd. | 10,817 | 6,808 | -4,009 | 0.02 | 0.01 | -0.01 | sell |