| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| First Light Asset Management, LLC | 3,002,045 | 4,780,560 | +1,778,515 | 2.60 | 3.78 | +1.19 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 371,000 | 1,996,000 | +1,625,000 | 0.02 | 0.11 | +0.08 | buy |
| Cormorant Asset Management, LP | 561,600 | 1,611,600 | +1,050,000 | 0.28 | 0.85 | +0.57 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,104,014 | 2,092,011 | +987,997 | 0.12 | 0.18 | +0.06 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,250,000 | 3,125,000 | +875,000 | 0.05 | 0.05 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 3,083,307 | 3,933,307 | +850,000 | 0.61 | 0.86 | +0.24 | buy |
| TCG Crossover Management, LLC | 2,040,816 | 2,890,816 | +850,000 | 1.82 | 2.72 | +0.90 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 833,993 | +833,993 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 254,446 | 1,023,122 | +768,676 | 0.01 | 0.02 | +0.02 | buy |
| Artal Group S.A. | 1,412,500 | 2,112,500 | +700,000 | 0.41 | 0.49 | +0.08 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,958,079 | 3,530,373 | +572,294 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 0 | 549,212 | +549,212 | 0.00 | 0.06 | +0.06 | buy |
| Nantahala Capital Management, LLC | 0 | 450,000 | +450,000 | 0.00 | 0.41 | +0.41 | buy |
| PFM Health Sciences, LP | 314,674 | 635,643 | +320,969 | 0.18 | 0.31 | +0.14 | buy |
| Affinity Asset Advisors, LLC | 830,546 | 1,135,702 | +305,156 | 1.53 | 1.62 | +0.09 | buy |
| Octagon Capital Advisors LP | 2,060,100 | 2,345,075 | +284,975 | 2.83 | 3.49 | +0.66 | buy |
| Woodline Partners LP | 0 | 123,461 | +123,461 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 0 | 122,882 | +122,882 | 0.00 | 0.27 | +0.27 | buy |
| Monashee Investment Management LLC | 0 | 103,191 | +103,191 | 0.00 | 0.12 | +0.12 | buy |
| EcoR1 Capital, LLC | 5,618,779 | 5,714,404 | +95,625 | 1.61 | 1.58 | -0.03 | buy |
| HighMark Wealth Management LLC | 0 | 93,000 | +93,000 | 0.00 | 0.51 | +0.51 | buy |
| TD ASSET MANAGEMENT INC | 228,644 | 321,168 | +92,524 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 206,856 | 253,197 | +46,341 | 0.64 | 0.46 | -0.18 | buy |
| GSA CAPITAL PARTNERS LLP | 13,587 | 56,383 | +42,796 | 0.01 | 0.04 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 108,048 | 140,894 | +32,846 | 0.00 | 0.00 | +0.00 | buy |
| Vestcor Inc | 0 | 20,300 | +20,300 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 16,385 | +16,385 | 0.00 | 0.01 | +0.01 | buy |
| Atria Investments, Inc | 0 | 16,018 | +16,018 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 12,300 | +12,300 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 923,120 | 935,151 | +12,031 | 0.01 | 0.01 | -0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 10,993 | +10,993 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 485,174 | 495,895 | +10,721 | 0.22 | 0.18 | -0.04 | buy |
| Sandia Investment Management LP | 0 | 10,000 | +10,000 | 0.00 | 0.11 | +0.11 | buy |
| VIRTUS ADVISERS, LLC | 0 | 9,116 | +9,116 | 0.00 | 0.04 | +0.04 | buy |
| Quarry LP | 6,500 | 9,608 | +3,108 | 0.03 | 0.04 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,730 | +1,730 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 204 | 1,228 | +1,024 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 709 | +709 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,010 | 1,298 | +288 | 0.00 | 0.00 | -0.00 | buy |
| GENERAL ATLANTIC, L.P. | 9,681,818 | 9,681,818 | 0 | 2.54 | 2.75 | +0.21 | hold |
| ADIRONDACK TRUST CO | 925 | 925 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 33,539 | 33,539 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 31,300 | 31,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 211 | 211 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 19,963,157 | 19,963,157 | 0 | 50.22 | 53.77 | +3.55 | hold |
| Global Retirement Partners, LLC | 700 | 700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 1,245,000 | 1,245,000 | 0 | 3.15 | 2.51 | -0.64 | hold |
| Vida Ventures Advisors, LLC | 3,931,818 | 3,931,818 | 0 | 24.68 | 38.83 | +14.15 | hold |
| Spire Wealth Management | 70 | 70 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tanager Wealth Management LLP | 696,096 | 696,096 | 0 | 1.27 | 0.94 | -0.33 | hold |
| Lynx1 Capital Management LP | 17,400 | 17,400 | 0 | 0.05 | 0.06 | +0.01 | hold |
| Exome Asset Management LLC | 274,900 | 274,900 | 0 | 2.66 | 2.21 | -0.45 | hold |
| FMR LLC | 2,787,194 | 2,787,194 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 1,156,723 | 1,156,723 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALDWELL SUTTER CAPITAL, INC. | 86 | 86 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NBC SECURITIES, INC. | 138 | 138 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,267 | 2,234 | -33 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 1,498 | 1,463 | -35 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 69,109 | 68,900 | -209 | 0.05 | 0.05 | -0.00 | sell |
| EntryPoint Capital, LLC | 9,636 | 8,136 | -1,500 | 0.10 | 0.03 | -0.06 | sell |
| Advisors Preferred, LLC | 1,825 | 0 | -1,825 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 76,984 | 73,277 | -3,707 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 10,817 | 6,808 | -4,009 | 0.02 | 0.01 | -0.01 | sell |
| Qube Research & Technologies Ltd | 8,944 | 3,523 | -5,421 | 0.00 | 0.00 | -0.00 | sell |
| State of Tennessee, Department of Treasury | 5,798 | 0 | -5,798 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 231,565 | 224,948 | -6,617 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 32,873 | 24,376 | -8,497 | 0.01 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 46,968 | 38,276 | -8,692 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 78,781 | 51,800 | -26,981 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 27,265 | 0 | -27,265 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 29,409 | 0 | -29,409 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 218,800 | 173,700 | -45,100 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 72,609 | 26,073 | -46,536 | 0.01 | 0.00 | -0.01 | sell |
| Trexquant Investment LP | 96,531 | 43,748 | -52,783 | 0.02 | 0.01 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 55,027 | 0 | -55,027 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 2,137,365 | 2,050,392 | -86,973 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 90,240 | 0 | -90,240 | 0.09 | 0.00 | -0.09 | sell |
| Ensign Peak Advisors, Inc | 125,157 | 0 | -125,157 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 287,393 | 49,485 | -237,908 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 379,314 | 87,210 | -292,104 | 0.05 | 0.01 | -0.04 | sell |
| Point72 Asset Management, L.P. | 2,257,718 | 1,762,004 | -495,714 | 0.07 | 0.05 | -0.02 | sell |