| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 50,000 | 1,529,836 | +1,479,836 | 0.01 | 0.29 | +0.28 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,954,000 | 8,403,000 | +1,449,000 | 0.19 | 0.19 | +0.00 | buy |
| Avoro Capital Advisors LLC | 4,050,000 | 5,000,000 | +950,000 | 0.91 | 1.15 | +0.24 | buy |
| Commodore Capital LP | 2,367,578 | 3,298,289 | +930,711 | 2.51 | 3.06 | +0.55 | buy |
| STEMPOINT CAPITAL LP | 593,335 | 1,265,672 | +672,337 | 2.73 | 5.35 | +2.63 | buy |
| JANUS HENDERSON GROUP PLC | 5,922,486 | 6,532,768 | +610,282 | 0.05 | 0.04 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,342,344 | 5,907,992 | +565,648 | 0.01 | 0.01 | -0.00 | buy |
| Siren, L.L.C. | 2,960,029 | 3,460,029 | +500,000 | 2.40 | 2.35 | -0.05 | buy |
| Saturn V Capital Management LP | 448,692 | 793,327 | +344,635 | 3.26 | 4.22 | +0.97 | buy |
| ADAR1 Capital Management, LLC | 216,166 | 296,766 | +80,600 | 0.60 | 0.63 | +0.04 | buy |
| GREAT POINT PARTNERS LLC | 149,702 | 225,000 | +75,298 | 1.14 | 1.92 | +0.78 | buy |
| Ally Bridge Group (NY) LLC | 243,086 | 293,986 | +50,900 | 3.15 | 3.21 | +0.06 | buy |
| Windmill Hill Asset Management Ltd | 117,913 | 163,768 | +45,855 | 0.52 | 0.59 | +0.07 | buy |
| Aberdeen Group plc | 90,883 | 119,389 | +28,506 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 142,744 | 166,944 | +24,200 | 1.84 | 1.81 | -0.03 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 267,887 | 290,836 | +22,949 | 0.22 | 0.25 | +0.03 | buy |
| Blue Owl Capital Holdings LP | 315,000 | 330,600 | +15,600 | 1.46 | 1.40 | -0.06 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 35,800 | 50,100 | +14,300 | 0.04 | 0.06 | +0.02 | buy |
| HighVista Strategies LLC | 39,020 | 40,684 | +1,664 | 0.22 | 0.20 | -0.02 | buy |
| HighMark Wealth Management LLC | 235,785 | 237,285 | +1,500 | 2.00 | 1.52 | -0.48 | buy |
| China Universal Asset Management Co., Ltd. | 18,311 | 19,181 | +870 | 0.02 | 0.02 | -0.00 | buy |
| OneAscent Financial Services LLC | 13,216 | 12,324 | -892 | 0.01 | 0.01 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 9,733 | 7,810 | -1,923 | 0.04 | 0.03 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 146,398 | 123,756 | -22,642 | 0.01 | 0.01 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 588,122 | 553,292 | -34,830 | 0.01 | 0.01 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 468,000 | 400,000 | -68,000 | 0.10 | 0.09 | -0.01 | sell |
| Tanager Wealth Management LLP | 696,096 | 598,044 | -98,052 | 1.30 | 0.93 | -0.38 | sell |
| J. Goldman & Co LP | 136,674 | 33,184 | -103,490 | 0.05 | 0.01 | -0.04 | sell |
| Cormorant Asset Management, LP | 2,261,600 | 2,086,600 | -175,000 | 2.45 | 2.04 | -0.40 | sell |
| PFM Health Sciences, LP | 570,546 | 344,972 | -225,574 | 0.60 | 0.39 | -0.21 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 232,758 | 5,000 | -227,758 | 0.70 | 0.01 | -0.69 | sell |
| Allostery Investments LP | 382,524 | 52,500 | -330,024 | 7.93 | 8.79 | +0.85 | sell |
| Octagon Capital Advisors LP | 1,425,000 | 1,030,000 | -395,000 | 4.03 | 2.97 | -1.06 | sell |
| First Light Asset Management, LLC | 4,874,124 | 4,293,411 | -580,713 | 8.00 | 7.31 | -0.69 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,095,533 | 510,779 | -584,754 | 0.15 | 0.05 | -0.10 | sell |
| Affinity Asset Advisors, LLC | 1,546,662 | 900,162 | -646,500 | 3.48 | 1.75 | -1.73 | sell |
| T. Rowe Price Investment Management, Inc. | 1,753,248 | 401 | -1,752,847 | 0.02 | 0.00 | -0.02 | sell |
| PERCEPTIVE ADVISORS LLC | 3,040,395 | 1,146,935 | -1,893,460 | 1.54 | 0.56 | -0.99 | sell |