| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 50,000 | 1,529,836 | +1,479,836 | 0.01 | 0.29 | +0.28 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,954,000 | 8,403,000 | +1,449,000 | 0.19 | 0.19 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,221,610 | +1,221,610 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 609,188 | 1,657,887 | +1,048,699 | 0.01 | 0.02 | +0.01 | buy |
| Polar Capital Holdings Plc | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.07 | +0.07 | buy |
| Avoro Capital Advisors LLC | 4,050,000 | 5,000,000 | +950,000 | 0.91 | 1.15 | +0.24 | buy |
| Commodore Capital LP | 2,367,578 | 3,298,289 | +930,711 | 2.51 | 3.06 | +0.55 | buy |
| STEMPOINT CAPITAL LP | 593,335 | 1,265,672 | +672,337 | 2.73 | 5.35 | +2.63 | buy |
| JANUS HENDERSON GROUP PLC | 5,922,486 | 6,532,768 | +610,282 | 0.05 | 0.04 | -0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,342,344 | 5,907,992 | +565,648 | 0.01 | 0.01 | -0.00 | buy |
| Deep Track Capital, LP | 0 | 500,000 | +500,000 | 0.00 | 0.21 | +0.21 | buy |
| Siren, L.L.C. | 2,960,029 | 3,460,029 | +500,000 | 2.40 | 2.35 | -0.05 | buy |
| Capital World Investors | 0 | 416,823 | +416,823 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 347,599 | +347,599 | 0.00 | 0.03 | +0.03 | buy |
| Saturn V Capital Management LP | 448,692 | 793,327 | +344,635 | 3.26 | 4.22 | +0.97 | buy |
| Point72 Asset Management, L.P. | 2,286,433 | 2,591,596 | +305,163 | 0.09 | 0.08 | -0.01 | buy |
| Qube Research & Technologies Ltd | 29,434 | 307,880 | +278,446 | 0.00 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 276,452 | +276,452 | 0.00 | 0.04 | +0.04 | buy |
| JPMORGAN CHASE & CO | 167,732 | 428,434 | +260,702 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 136,027 | 343,318 | +207,291 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 178,000 | 384,900 | +206,900 | 0.00 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 4,334,318 | 4,529,318 | +195,000 | 0.34 | 0.27 | -0.06 | buy |
| GOLDMAN SACHS GROUP INC | 401,764 | 559,283 | +157,519 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 73,483 | 209,750 | +136,267 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 438,133 | 559,744 | +121,611 | 0.01 | 0.01 | +0.00 | buy |
| Bollard Group LLC | 0 | 100,362 | +100,362 | 0.00 | 0.03 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 216,166 | 296,766 | +80,600 | 0.60 | 0.63 | +0.04 | buy |
| GREAT POINT PARTNERS LLC | 149,702 | 225,000 | +75,298 | 1.17 | 1.92 | +0.75 | buy |
| LAZARD ASSET MANAGEMENT LLC | 73,718 | 131,351 | +57,633 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 15,300 | 72,144 | +56,844 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 55,200 | +55,200 | 0.00 | 0.01 | +0.01 | buy |
| Ally Bridge Group (NY) LLC | 243,086 | 293,986 | +50,900 | 3.15 | 3.21 | +0.06 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 46,665 | +46,665 | 0.00 | 0.01 | +0.01 | buy |
| Windmill Hill Asset Management Ltd | 117,913 | 163,768 | +45,855 | 0.52 | 0.59 | +0.07 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 39,379 | +39,379 | 0.00 | 0.00 | +0.00 | buy |
| Meridian Wealth Partners, LLC | 0 | 38,101 | +38,101 | 0.00 | 0.07 | +0.07 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,092,754 | 1,130,708 | +37,954 | 0.01 | 0.01 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,118 | 34,972 | +33,854 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 90,883 | 119,389 | +28,506 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 60,441 | 87,435 | +26,994 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 142,744 | 166,944 | +24,200 | 1.84 | 1.81 | -0.03 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 267,887 | 290,836 | +22,949 | 0.22 | 0.25 | +0.03 | buy |
| Legal & General Group Plc | 76,051 | 98,256 | +22,205 | 0.00 | 0.00 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 0 | 19,653 | +19,653 | 0.00 | 0.02 | +0.02 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 16,619 | +16,619 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 0 | 15,764 | +15,764 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 315,000 | 330,600 | +15,600 | 1.46 | 1.40 | -0.06 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 302,646 | 317,574 | +14,928 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 35,800 | 50,100 | +14,300 | 0.05 | 0.06 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 138,767 | 149,451 | +10,684 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 0 | 8,999 | +8,999 | 0.00 | 0.03 | +0.03 | buy |
| HighVista Strategies LLC | 39,020 | 40,684 | +1,664 | 0.22 | 0.20 | -0.02 | buy |
| Clearstead Advisors, LLC | 0 | 1,638 | +1,638 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 2,541,999 | 2,543,539 | +1,540 | 0.01 | 0.01 | -0.00 | buy |
| HighMark Wealth Management LLC | 235,785 | 237,285 | +1,500 | 2.00 | 1.52 | -0.48 | buy |
| NATIONAL BANK OF CANADA /FI/ | 600 | 1,600 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 18,311 | 19,181 | +870 | 0.02 | 0.02 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,055 | 3,689 | +634 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 1,330 | 1,821 | +491 | 0.00 | 0.00 | +0.00 | buy |
| Atria Investments, Inc | 13,547 | 13,929 | +382 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| GENERAL ATLANTIC, L.P. | 9,681,818 | 9,681,818 | 0 | 4.67 | 3.51 | -1.17 | hold |
| ADIRONDACK TRUST CO | 925 | 925 | 0 | 0.01 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 29,670 | 29,670 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 50,000 | 50,000 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Rathbones Group PLC | 16,500 | 16,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nantahala Capital Management, LLC | 554,803 | 554,803 | 0 | 0.66 | 0.52 | -0.14 | hold |
| Daiwa Securities Group Inc. | 294 | 294 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 41,900 | 41,900 | 0 | 0.02 | 0.02 | -0.00 | hold |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 257,418 | 257,418 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 19,963,157 | 19,963,157 | 0 | 65.59 | 61.40 | -4.19 | hold |
| Woodline Partners LP | 400,278 | 400,278 | 0 | 0.04 | 0.03 | -0.01 | hold |
| 5AM Venture Management, LLC | 830,945 | 830,945 | 0 | 4.52 | 4.20 | -0.32 | hold |
| TCG Crossover Management, LLC | 2,890,816 | 2,890,816 | 0 | 5.67 | 4.34 | -1.33 | hold |
| Index Venture Life Associates VI Ltd | 9,961,789 | 9,961,789 | 0 | 100.00 | 100.00 | 0.00 | hold |
| Washington Trust Advisors, Inc. | 184 | 184 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Foresite Capital Management VI LLC | 1,253,379 | 1,253,379 | 0 | 9.87 | 9.26 | -0.61 | hold |
| GF FUND MANAGEMENT CO. LTD. | 2,283 | 2,283 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 3,826,194 | 3,826,194 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NBC SECURITIES, INC. | 138 | 138 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bell Investment Advisors, Inc | 31 | 0 | -31 | 0.00 | 0.00 | -0.00 | sell |
| CALDWELL SUTTER CAPITAL, INC. | 43 | 0 | -43 | 0.00 | 0.00 | -0.00 | sell |
| BELLEVUE ASSET MANAGEMENT, LLC | 70 | 0 | -70 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 755 | 682 | -73 | 0.00 | 0.00 | -0.00 | sell |
| Global Retirement Partners, LLC | 700 | 350 | -350 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 919 | 479 | -440 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 46,644 | 45,912 | -732 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 12,090 | 11,356 | -734 | 0.00 | 0.00 | -0.00 | sell |
| OneAscent Financial Services LLC | 13,216 | 12,324 | -892 | 0.01 | 0.01 | -0.00 | sell |
| GAMMA Investing LLC | 4,295 | 3,191 | -1,104 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 9,733 | 7,810 | -1,923 | 0.04 | 0.03 | -0.00 | sell |
| Squarepoint Ops LLC | 42,862 | 39,760 | -3,102 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 3,215 | 0 | -3,215 | 0.03 | 0.00 | -0.03 | sell |
| XTX Topco Ltd | 41,057 | 35,898 | -5,159 | 0.03 | 0.02 | -0.01 | sell |
| ROYAL BANK OF CANADA | 6,755 | 0 | -6,755 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 10,257 | 0 | -10,257 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 11,111 | 0 | -11,111 | 0.02 | 0.00 | -0.02 | sell |
| Graham Capital Management, L.P. | 14,617 | 0 | -14,617 | 0.01 | 0.00 | -0.01 | sell |