| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,250,000 | 2,830,500 | +580,500 | 0.03 | 0.04 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 171,625 | 337,544 | +165,919 | 0.04 | 0.09 | +0.05 | buy |
| Affinity Asset Advisors, LLC | 900,723 | 1,018,091 | +117,368 | 2.19 | 2.15 | -0.04 | buy |
| Octagon Capital Advisors LP | 411,928 | 475,600 | +63,672 | 0.36 | 0.54 | +0.19 | buy |
| Kynam Capital Management, LP | 729,077 | 730,472 | +1,395 | 0.69 | 0.79 | +0.09 | buy |
| China Universal Asset Management Co., Ltd. | 691 | 1,357 | +666 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 877,193 | 756,891 | -120,302 | 1.92 | 1.52 | -0.40 | sell |
| BVF INC/IL | 9,423,215 | 9,103,054 | -320,161 | 1.63 | 1.59 | -0.04 | sell |
| Woodline Partners LP | 687,763 | 210,204 | -477,559 | 0.05 | 0.02 | -0.03 | sell |