| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 833,993 | 3,556,023 | +2,722,030 | 0.00 | 0.03 | +0.03 | buy |
| PERCEPTIVE ADVISORS LLC | 3,933,307 | 6,282,290 | +2,348,983 | 0.86 | 2.13 | +1.27 | buy |
| First Light Asset Management, LLC | 4,780,560 | 5,940,132 | +1,159,572 | 3.78 | 7.90 | +4.12 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,530,373 | 4,679,021 | +1,148,648 | 0.00 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,125,000 | 4,195,000 | +1,070,000 | 0.05 | 0.12 | +0.07 | buy |
| Cormorant Asset Management, LP | 1,611,600 | 2,561,600 | +950,000 | 0.84 | 2.17 | +1.33 | buy |
| BAKER BROS. ADVISORS LP | 549,212 | 1,227,178 | +677,966 | 0.06 | 0.20 | +0.14 | buy |
| Woodline Partners LP | 123,461 | 516,379 | +392,918 | 0.01 | 0.07 | +0.06 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,023,122 | 681,421 | +341,701 | 0.03 | 0.03 | 0.00 | sell |
| TD ASSET MANAGEMENT INC | 321,168 | 558,714 | +237,546 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 10,993 | 177,553 | +166,560 | 0.00 | 0.01 | +0.01 | buy |
| HighMark Wealth Management LLC | 93,000 | 167,135 | +74,135 | 0.51 | 1.46 | +0.96 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,092,011 | 2,161,728 | +69,717 | 0.18 | 0.30 | +0.11 | buy |
| Nantahala Capital Management, LLC | 450,000 | 512,647 | +62,647 | 0.24 | 0.41 | +0.18 | buy |
| Monashee Investment Management LLC | 103,191 | 161,293 | +58,102 | 0.12 | 0.28 | +0.16 | buy |
| 5AM Venture Management, LLC | 1,245,000 | 1,285,000 | +40,000 | 2.51 | 4.25 | +1.73 | buy |
| GSA CAPITAL PARTNERS LLP | 56,383 | 93,658 | +37,275 | 0.04 | 0.13 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,808 | 13,593 | +6,785 | 0.01 | 0.02 | +0.02 | buy |
| EntryPoint Capital, LLC | 8,136 | 13,651 | +5,515 | 0.11 | 0.12 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 9,116 | 9,285 | +169 | 0.04 | 0.07 | +0.03 | buy |
| Rathbones Group PLC | 31,300 | 30,400 | -900 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 122,882 | 120,351 | -2,531 | 0.27 | 0.45 | +0.19 | sell |
| Sandia Investment Management LP | 10,000 | 5,000 | -5,000 | 0.11 | 0.13 | +0.02 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 68,900 | 36,900 | -32,000 | 0.05 | 0.05 | -0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 495,895 | 429,701 | -66,194 | 0.18 | 0.31 | +0.13 | sell |
| Exome Asset Management LLC | 274,900 | 138,152 | -136,748 | 2.21 | 1.49 | -0.72 | sell |
| Affinity Asset Advisors, LLC | 1,135,702 | 965,612 | -170,090 | 1.18 | 2.11 | +0.92 | sell |
| ADAR1 Capital Management, LLC | 253,197 | 23,302 | -229,895 | 0.46 | 0.06 | -0.40 | sell |
| Octagon Capital Advisors LP | 2,345,075 | 2,012,052 | -333,023 | 3.49 | 5.15 | +1.66 | sell |
| PFM Health Sciences, LP | 635,643 | 269,158 | -366,485 | 0.28 | 0.24 | -0.04 | sell |
| EcoR1 Capital, LLC | 5,714,404 | 3,223,851 | -2,490,553 | 1.58 | 1.76 | +0.19 | sell |