| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 833,993 | 3,556,023 | +2,722,030 | 0.00 | 0.03 | +0.03 | buy |
| PERCEPTIVE ADVISORS LLC | 3,933,307 | 6,282,290 | +2,348,983 | 0.86 | 2.16 | +1.30 | buy |
| Avidity Partners Management LP | 0 | 2,132,000 | +2,132,000 | 0.00 | 1.74 | +1.74 | buy |
| Commodore Capital LP | 0 | 1,350,000 | +1,350,000 | 0.00 | 1.35 | +1.35 | buy |
| Deep Track Capital, LP | 0 | 1,350,000 | +1,350,000 | 0.00 | 0.69 | +0.69 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 1,294,864 | +1,294,864 | 0.00 | 0.01 | +0.01 | buy |
| First Light Asset Management, LLC | 4,780,560 | 5,940,132 | +1,159,572 | 3.78 | 7.90 | +4.12 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,530,373 | 4,679,021 | +1,148,648 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,156,723 | 2,302,546 | +1,145,823 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,125,000 | 4,195,000 | +1,070,000 | 0.05 | 0.12 | +0.07 | buy |
| Point72 Asset Management, L.P. | 1,762,004 | 2,715,663 | +953,659 | 0.05 | 0.15 | +0.10 | buy |
| Cormorant Asset Management, LP | 1,611,600 | 2,561,600 | +950,000 | 0.85 | 2.17 | +1.33 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 1,996,000 | 2,814,318 | +818,318 | 0.11 | 0.25 | +0.14 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 744,592 | +744,592 | 0.00 | 2.68 | +2.68 | buy |
| BAKER BROS. ADVISORS LP | 549,212 | 1,227,178 | +677,966 | 0.06 | 0.20 | +0.14 | buy |
| Polar Capital Holdings Plc | 0 | 640,000 | +640,000 | 0.00 | 0.05 | +0.05 | buy |
| CITADEL ADVISORS LLC | 38,276 | 587,518 | +549,242 | 0.00 | 0.01 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 400,000 | +400,000 | 0.00 | 0.46 | +0.46 | buy |
| Woodline Partners LP | 123,461 | 516,379 | +392,918 | 0.01 | 0.07 | +0.06 | buy |
| Ally Bridge Group (NY) LLC | 0 | 309,614 | +309,614 | 0.00 | 2.65 | +2.65 | buy |
| LORD, ABBETT & CO. LLC | 0 | 269,205 | +269,205 | 0.00 | 0.01 | +0.01 | buy |
| Blue Owl Capital Holdings LP | 0 | 255,000 | +255,000 | 0.00 | 0.79 | +0.79 | buy |
| BANK OF AMERICA CORP /DE/ | 73,277 | 313,338 | +240,061 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 321,168 | 558,714 | +237,546 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 935,151 | 1,139,546 | +204,395 | 0.01 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 49,485 | 230,379 | +180,894 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 177,260 | +177,260 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 10,993 | 177,553 | +166,560 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 0 | 135,903 | +135,903 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,787,194 | 2,916,494 | +129,300 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 43,748 | 170,951 | +127,203 | 0.01 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 140,894 | 264,969 | +124,075 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 26,073 | 134,120 | +108,047 | 0.00 | 0.03 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 100,613 | +100,613 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 3,523 | 96,515 | +92,992 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 83,662 | +83,662 | 0.00 | 0.40 | +0.40 | buy |
| Artia Global Partners LP | 0 | 80,380 | +80,380 | 0.00 | 0.36 | +0.36 | buy |
| Ensign Peak Advisors, Inc | 0 | 79,000 | +79,000 | 0.00 | 0.00 | +0.00 | buy |
| HighMark Wealth Management LLC | 93,000 | 167,135 | +74,135 | 0.51 | 1.46 | +0.96 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 70,000 | +70,000 | 0.00 | 0.04 | +0.04 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,092,011 | 2,161,728 | +69,717 | 0.18 | 0.30 | +0.11 | buy |
| Nantahala Capital Management, LLC | 450,000 | 512,647 | +62,647 | 0.41 | 0.69 | +0.28 | buy |
| Monashee Investment Management LLC | 103,191 | 161,293 | +58,102 | 0.12 | 0.28 | +0.16 | buy |
| TWO SIGMA INVESTMENTS, LP | 51,800 | 103,908 | +52,108 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 0 | 48,592 | +48,592 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 48,078 | +48,078 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 46,116 | +46,116 | 0.00 | 0.25 | +0.25 | buy |
| 5AM Venture Management, LLC | 1,245,000 | 1,285,000 | +40,000 | 2.51 | 4.25 | +1.73 | buy |
| GSA CAPITAL PARTNERS LLP | 56,383 | 93,658 | +37,275 | 0.04 | 0.11 | +0.08 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 173,700 | 209,600 | +35,900 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 32,917 | +32,917 | 0.00 | 0.04 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 27,884 | +27,884 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 24,376 | 49,111 | +24,735 | 0.00 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 33,539 | 56,597 | +23,058 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 20,121 | +20,121 | 0.00 | 0.00 | +0.00 | buy |
| Harbour Capital Advisors, LLC | 0 | 16,675 | +16,675 | 0.00 | 0.06 | +0.06 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 13,055 | +13,055 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,228 | 14,094 | +12,866 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 11,721 | +11,721 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,808 | 13,593 | +6,785 | 0.01 | 0.02 | +0.02 | buy |
| ROYAL BANK OF CANADA | 0 | 6,279 | +6,279 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 8,136 | 13,651 | +5,515 | 0.03 | 0.12 | +0.09 | buy |
| Advisors Preferred, LLC | 0 | 4,555 | +4,555 | 0.00 | 0.01 | +0.01 | buy |
| Golden State Equity Partners | 0 | 1,700 | +1,700 | 0.00 | 0.01 | +0.01 | buy |
| GAMMA Investing LLC | 1,463 | 2,972 | +1,509 | 0.00 | 0.00 | +0.00 | buy |
| Atria Investments, Inc | 16,018 | 17,134 | +1,116 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,298 | 2,289 | +991 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,730 | 2,556 | +826 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 350 | +350 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 709 | 1,015 | +306 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 9,116 | 9,285 | +169 | 0.04 | 0.07 | +0.03 | buy |
| SIMPLEX TRADING, LLC | 0 | 108 | +108 | 0.00 | 0.00 | +0.00 | buy |
| GENERAL ATLANTIC, L.P. | 9,681,818 | 9,681,818 | 0 | 2.75 | 4.40 | +1.65 | hold |
| ADIRONDACK TRUST CO | 925 | 925 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Daiwa Securities Group Inc. | 211 | 211 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 19,963,157 | 19,963,157 | 0 | 53.77 | 60.35 | +6.59 | hold |
| Global Retirement Partners, LLC | 700 | 700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vida Ventures Advisors, LLC | 3,931,818 | 3,931,818 | 0 | 38.83 | 45.36 | +6.53 | hold |
| TCG Crossover Management, LLC | 2,890,816 | 2,890,816 | 0 | 2.72 | 3.92 | +1.20 | hold |
| Tanager Wealth Management LLP | 696,096 | 696,096 | 0 | 0.94 | 1.50 | +0.56 | hold |
| Lynx1 Capital Management LP | 17,400 | 17,400 | 0 | 0.06 | 0.10 | +0.04 | hold |
| CALDWELL SUTTER CAPITAL, INC. | 86 | 86 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NBC SECURITIES, INC. | 138 | 138 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,234 | 2,199 | -35 | 0.00 | 0.00 | +0.00 | sell |
| Spire Wealth Management | 70 | 0 | -70 | 0.00 | 0.00 | -0.00 | sell |
| Rathbones Group PLC | 31,300 | 30,400 | -900 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 122,882 | 120,351 | -2,531 | 0.27 | 0.45 | +0.19 | sell |
| Sandia Investment Management LP | 10,000 | 5,000 | -5,000 | 0.11 | 0.13 | +0.02 | sell |
| XTX Topco Ltd | 16,385 | 10,174 | -6,211 | 0.01 | 0.01 | -0.00 | sell |
| Quarry LP | 9,608 | 0 | -9,608 | 0.04 | 0.00 | -0.04 | sell |
| Schonfeld Strategic Advisors LLC | 12,300 | 0 | -12,300 | 0.00 | 0.00 | -0.00 | sell |
| Vestcor Inc | 20,300 | 0 | -20,300 | 0.01 | 0.00 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 68,900 | 36,900 | -32,000 | 0.05 | 0.05 | -0.01 | sell |
| MARSHALL WACE, LLP | 224,948 | 180,853 | -44,095 | 0.00 | 0.00 | +0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 495,895 | 429,701 | -66,194 | 0.18 | 0.31 | +0.13 | sell |
| ExodusPoint Capital Management, LP | 87,210 | 0 | -87,210 | 0.01 | 0.00 | -0.01 | sell |
| Exome Asset Management LLC | 274,900 | 138,152 | -136,748 | 2.21 | 1.49 | -0.72 | sell |
| Affinity Asset Advisors, LLC | 1,135,702 | 965,612 | -170,090 | 1.62 | 2.40 | +0.78 | sell |