| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 5,000,000 | 10,808,080 | +5,808,080 | 1.15 | 3.39 | +2.24 | buy |
| FMR LLC | 3,826,194 | 6,277,243 | +2,451,049 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 1,146,935 | 3,100,902 | +1,953,967 | 0.57 | 2.17 | +1.61 | buy |
| FEDERATED HERMES, INC. | 0 | 1,749,650 | +1,749,650 | 0.00 | 0.07 | +0.07 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8,403,000 | 10,035,000 | +1,632,000 | 0.19 | 0.39 | +0.20 | buy |
| RTW INVESTMENTS, LP | 1,529,836 | 2,291,747 | +761,911 | 0.29 | 0.68 | +0.40 | buy |
| EcoR1 Capital, LLC | 0 | 550,000 | +550,000 | 0.00 | 0.64 | +0.64 | buy |
| Logos Global Management LP | 0 | 525,000 | +525,000 | 0.00 | 1.26 | +1.26 | buy |
| BANK OF AMERICA CORP /DE/ | 135,798 | 553,007 | +417,209 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 344,972 | 666,196 | +321,224 | 0.39 | 1.38 | +0.98 | buy |
| Capital World Investors | 416,823 | 684,805 | +267,982 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 0 | 247,387 | +247,387 | 0.00 | 0.06 | +0.06 | buy |
| TCG Crossover Management, LLC | 2,890,816 | 3,136,480 | +245,664 | 4.34 | 3.74 | -0.60 | buy |
| Jain Global LLC | 0 | 241,975 | +241,975 | 0.00 | 0.08 | +0.08 | buy |
| Affinity Asset Advisors, LLC | 900,162 | 1,107,162 | +207,000 | 1.75 | 2.50 | +0.75 | buy |
| TANG CAPITAL MANAGEMENT LLC | 50,000 | 200,000 | +150,000 | 0.03 | 0.19 | +0.15 | buy |
| CITADEL ADVISORS LLC | 0 | 137,201 | +137,201 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 5,000 | 141,238 | +136,238 | 0.01 | 0.50 | +0.48 | buy |
| Artia Global Partners LP | 0 | 133,291 | +133,291 | 0.00 | 0.57 | +0.57 | buy |
| Caption Management, LLC | 0 | 125,309 | +125,309 | 0.00 | 0.18 | +0.18 | buy |
| Verition Fund Management LLC | 0 | 114,306 | +114,306 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 108,002 | +108,002 | 0.00 | 0.00 | +0.00 | buy |
| Eagle Health Investments LP | 0 | 103,100 | +103,100 | 0.00 | 0.66 | +0.66 | buy |
| Cinctive Capital Management LP | 0 | 92,628 | +92,628 | 0.00 | 0.11 | +0.11 | buy |
| Rock Springs Capital Management LP | 0 | 69,240 | +69,240 | 0.00 | 0.10 | +0.10 | buy |
| FRED ALGER MANAGEMENT, LLC | 123,756 | 190,360 | +66,604 | 0.01 | 0.02 | +0.01 | buy |
| Foresite Capital Management VI LLC | 1,253,379 | 1,314,019 | +60,640 | 9.26 | 12.31 | +3.05 | buy |
| Schonfeld Strategic Advisors LLC | 118,163 | 172,696 | +54,533 | 0.01 | 0.03 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 15,764 | 64,389 | +48,625 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 140,965 | 182,300 | +41,335 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 381,125 | 408,386 | +27,261 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 23,586 | +23,586 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 40,684 | 63,301 | +22,617 | 0.20 | 0.38 | +0.18 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 18,761 | +18,761 | 0.00 | 0.04 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 2,543,539 | 2,558,414 | +14,875 | 0.01 | 0.02 | +0.01 | buy |
| Pictet Asset Management Holding SA | 0 | 13,869 | +13,869 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 16,619 | 25,845 | +9,226 | 0.01 | 0.05 | +0.03 | buy |
| DnB Asset Management AS | 0 | 8,988 | +8,988 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 8,727 | +8,727 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 87,435 | 95,032 | +7,597 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 50,851 | 57,810 | +6,959 | 0.01 | 0.01 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 6,690 | +6,690 | 0.00 | 0.03 | +0.03 | buy |
| ROYAL BANK OF CANADA | 0 | 5,404 | +5,404 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 510,779 | 515,979 | +5,200 | 0.05 | 0.09 | +0.04 | buy |
| Rockefeller Capital Management L.P. | 0 | 3,468 | +3,468 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 98,256 | 101,693 | +3,437 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 479 | 3,911 | +3,432 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 2,622 | +2,622 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 2,461 | +2,461 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 7,810 | 9,451 | +1,641 | 0.03 | 0.07 | +0.03 | buy |
| GAMMA Investing LLC | 3,191 | 3,612 | +421 | 0.00 | 0.00 | +0.00 | buy |
| Aspect Partners, LLC | 0 | 230 | +230 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 81 | +81 | 0.00 | 0.00 | +0.00 | buy |
| BELLEVUE ASSET MANAGEMENT, LLC | 0 | 70 | +70 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,821 | 1,844 | +23 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,689 | 3,709 | +20 | 0.00 | 0.00 | +0.00 | buy |
| GENERAL ATLANTIC, L.P. | 9,681,818 | 9,681,818 | 0 | 3.51 | 7.05 | +3.54 | hold |
| ADIRONDACK TRUST CO | 925 | 925 | 0 | 0.00 | 0.01 | +0.00 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 29,670 | 29,670 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 17 | 17 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 559,744 | 559,744 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Daiwa Securities Group Inc. | 294 | 294 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 19,963,157 | 19,963,157 | 0 | 61.40 | 65.03 | +3.64 | hold |
| Global Retirement Partners, LLC | 350 | 350 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighMark Wealth Management LLC | 237,285 | 237,285 | 0 | 1.52 | 2.53 | +1.01 | hold |
| Windmill Hill Asset Management Ltd | 163,768 | 163,768 | 0 | 0.59 | 1.04 | +0.45 | hold |
| Index Venture Life Associates VI Ltd | 9,961,789 | 9,961,789 | 0 | 100.00 | 100.00 | 0.00 | hold |
| Tanager Wealth Management LLP | 598,044 | 598,044 | 0 | 0.93 | 1.52 | +0.60 | hold |
| Washington Trust Advisors, Inc. | 184 | 184 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NBC SECURITIES, INC. | 138 | 138 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 682 | 481 | -201 | 0.00 | 0.00 | +0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 2,283 | 2,064 | -219 | 0.00 | 0.00 | +0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 401 | 20 | -381 | 0.00 | 0.00 | -0.00 | sell |
| Atria Investments, Inc | 13,929 | 13,518 | -411 | 0.00 | 0.00 | +0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 1,600 | 0 | -1,600 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 1,638 | 0 | -1,638 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 19,181 | 16,816 | -2,365 | 0.02 | 0.03 | +0.01 | sell |
| BARCLAYS PLC | 7,519 | 4,968 | -2,551 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 347,599 | 343,207 | -4,392 | 0.03 | 0.04 | +0.02 | sell |
| Coastal Bridge Advisors, LLC | 19,653 | 13,102 | -6,551 | 0.02 | 0.02 | +0.00 | sell |
| Quarry LP | 8,999 | 0 | -8,999 | 0.03 | 0.00 | -0.03 | sell |
| Engineers Gate Manager LP | 11,356 | 0 | -11,356 | 0.00 | 0.00 | -0.00 | sell |
| OneAscent Financial Services LLC | 12,324 | 0 | -12,324 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 72,144 | 57,444 | -14,700 | 0.00 | 0.00 | +0.00 | sell |
| Rathbones Group PLC | 16,500 | 0 | -16,500 | 0.00 | 0.00 | -0.00 | sell |
| Meridian Wealth Partners, LLC | 38,101 | 18,101 | -20,000 | 0.07 | 0.06 | -0.01 | sell |
| J. Goldman & Co LP | 33,184 | 13,105 | -20,079 | 0.01 | 0.01 | -0.00 | sell |
| Squarepoint Ops LLC | 39,760 | 19,413 | -20,347 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 41,900 | 21,319 | -20,581 | 0.02 | 0.01 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 400,000 | 378,000 | -22,000 | 0.20 | 0.29 | +0.09 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 50,100 | 26,656 | -23,444 | 0.06 | 0.05 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 34,972 | 1,198 | -33,774 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 1,130,708 | 1,096,704 | -34,004 | 0.01 | 0.01 | +0.01 | sell |
| XTX Topco Ltd | 35,898 | 0 | -35,898 | 0.02 | 0.00 | -0.02 | sell |
| OMERS ADMINISTRATION Corp | 55,200 | 17,500 | -37,700 | 0.01 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 39,379 | 0 | -39,379 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 45,912 | 0 | -45,912 | 0.00 | 0.00 | -0.00 | sell |