| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Medicxi Ventures Management (Jersey) Ltd | 19,963,157 | 19,963,157 | 0 | 61.40 | 65.03 | +3.64 | hold |
| Avoro Capital Advisors LLC | 5,000,000 | 10,808,080 | +5,808,080 | 1.15 | 3.39 | +2.24 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8,403,000 | 10,035,000 | +1,632,000 | 0.19 | 0.39 | +0.20 | buy |
| Index Venture Life Associates VI Ltd | 9,961,789 | 9,961,789 | 0 | 100.00 | 100.00 | 0.00 | hold |
| GENERAL ATLANTIC, L.P. | 9,681,818 | 9,681,818 | 0 | 3.51 | 7.05 | +3.54 | hold |
| FMR LLC | 3,826,194 | 6,277,243 | +2,451,049 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 6,532,768 | 5,408,199 | -1,124,569 | 0.04 | 0.06 | +0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,907,992 | 4,804,056 | -1,103,936 | 0.01 | 0.01 | +0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 4,529,318 | 4,331,318 | -198,000 | 0.27 | 0.59 | +0.32 | sell |
| First Light Asset Management, LLC | 4,293,411 | 3,635,816 | -657,595 | 7.31 | 8.31 | +1.00 | sell |
| Siren, L.L.C. | 3,460,029 | 3,227,517 | -232,512 | 2.35 | 3.06 | +0.71 | sell |
| TCG Crossover Management, LLC | 2,890,816 | 3,136,480 | +245,664 | 4.34 | 3.74 | -0.60 | buy |
| PERCEPTIVE ADVISORS LLC | 1,146,935 | 3,100,902 | +1,953,967 | 0.57 | 2.17 | +1.61 | buy |
| Commodore Capital LP | 3,298,289 | 2,850,000 | -448,289 | 3.06 | 3.37 | +0.31 | sell |
| FRANKLIN RESOURCES INC | 2,543,539 | 2,558,414 | +14,875 | 0.01 | 0.02 | +0.01 | buy |
| RTW INVESTMENTS, LP | 1,529,836 | 2,291,747 | +761,911 | 0.29 | 0.68 | +0.40 | buy |
| Cormorant Asset Management, LP | 2,086,600 | 1,925,000 | -161,600 | 2.04 | 3.22 | +1.18 | sell |
| FEDERATED HERMES, INC. | 0 | 1,749,650 | +1,749,650 | 0.00 | 0.07 | +0.07 | buy |
| Foresite Capital Management VI LLC | 1,253,379 | 1,314,019 | +60,640 | 9.26 | 12.31 | +3.05 | buy |
| MORGAN STANLEY | 1,793,471 | 1,124,445 | -669,026 | 0.00 | 0.00 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 900,162 | 1,107,162 | +207,000 | 1.75 | 2.50 | +0.75 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,130,708 | 1,096,704 | -34,004 | 0.01 | 0.01 | +0.01 | sell |
| Point72 Asset Management, L.P. | 2,591,596 | 1,072,665 | -1,518,931 | 0.08 | 0.06 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,657,887 | 902,268 | -755,619 | 0.02 | 0.02 | -0.00 | sell |
| Octagon Capital Advisors LP | 1,030,000 | 830,000 | -200,000 | 2.97 | 3.14 | +0.17 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,221,610 | 805,611 | -415,999 | 0.04 | 0.04 | +0.00 | sell |
| Saturn V Capital Management LP | 793,327 | 734,539 | -58,788 | 4.22 | 3.91 | -0.32 | sell |
| Capital World Investors | 416,823 | 684,805 | +267,982 | 0.00 | 0.00 | +0.00 | buy |
| 5AM Venture Management, LLC | 830,945 | 680,945 | -150,000 | 4.20 | 6.05 | +1.85 | sell |
| PFM Health Sciences, LP | 344,972 | 666,196 | +321,224 | 0.39 | 1.38 | +0.98 | buy |
| STEMPOINT CAPITAL LP | 1,265,672 | 655,385 | -610,287 | 5.35 | 3.20 | -2.15 | sell |
| Tanager Wealth Management LLP | 598,044 | 598,044 | 0 | 0.93 | 1.52 | +0.60 | hold |
| Ensign Peak Advisors, Inc | 559,744 | 559,744 | 0 | 0.01 | 0.02 | +0.01 | hold |
| BANK OF AMERICA CORP /DE/ | 135,798 | 553,007 | +417,209 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 550,000 | +550,000 | 0.00 | 0.64 | +0.64 | buy |
| Logos Global Management LP | 0 | 525,000 | +525,000 | 0.00 | 1.26 | +1.26 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 510,779 | 515,979 | +5,200 | 0.05 | 0.09 | +0.04 | buy |
| TD ASSET MANAGEMENT INC | 553,292 | 466,960 | -86,332 | 0.01 | 0.01 | +0.00 | sell |
| BlackRock, Inc. | 381,125 | 408,386 | +27,261 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 554,803 | 404,803 | -150,000 | 0.52 | 0.61 | +0.09 | sell |
| ARMISTICE CAPITAL, LLC | 400,000 | 378,000 | -22,000 | 0.20 | 0.29 | +0.09 | sell |
| Candriam S.C.A. | 347,599 | 343,207 | -4,392 | 0.03 | 0.04 | +0.02 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 317,574 | 262,146 | -55,428 | 0.00 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 559,283 | 247,555 | -311,728 | 0.00 | 0.00 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 0 | 247,387 | +247,387 | 0.00 | 0.06 | +0.06 | buy |
| Jain Global LLC | 0 | 241,975 | +241,975 | 0.00 | 0.08 | +0.08 | buy |
| JPMORGAN CHASE & CO | 428,434 | 241,895 | -186,539 | 0.00 | 0.00 | -0.00 | sell |
| HighMark Wealth Management LLC | 237,285 | 237,285 | 0 | 1.52 | 2.53 | +1.01 | hold |
| TANG CAPITAL MANAGEMENT LLC | 50,000 | 200,000 | +150,000 | 0.03 | 0.19 | +0.15 | buy |
| FRED ALGER MANAGEMENT, LLC | 123,756 | 190,360 | +66,604 | 0.01 | 0.02 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 290,836 | 186,399 | -104,437 | 0.25 | 0.29 | +0.04 | sell |
| Russell Investments Group, Ltd. | 140,965 | 182,300 | +41,335 | 0.00 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 118,163 | 172,696 | +54,533 | 0.01 | 0.03 | +0.02 | buy |
| Blue Owl Capital Holdings LP | 330,600 | 169,450 | -161,150 | 1.40 | 1.28 | -0.13 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 384,900 | 164,600 | -220,300 | 0.01 | 0.01 | -0.00 | sell |
| Windmill Hill Asset Management Ltd | 163,768 | 163,768 | 0 | 0.59 | 1.04 | +0.45 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 5,000 | 141,238 | +136,238 | 0.01 | 0.50 | +0.48 | buy |
| CITADEL ADVISORS LLC | 0 | 137,201 | +137,201 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 133,291 | +133,291 | 0.00 | 0.57 | +0.57 | buy |
| Caption Management, LLC | 0 | 125,309 | +125,309 | 0.00 | 0.18 | +0.18 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 257,418 | 116,397 | -141,021 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 0 | 114,306 | +114,306 | 0.00 | 0.02 | +0.02 | buy |
| MARSHALL WACE, LLP | 343,318 | 113,590 | -229,728 | 0.01 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 108,002 | +108,002 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 400,278 | 107,671 | -292,607 | 0.03 | 0.01 | -0.02 | sell |
| Cubist Systematic Strategies, LLC | 276,452 | 103,909 | -172,543 | 0.04 | 0.04 | -0.00 | sell |
| Eagle Health Investments LP | 0 | 103,100 | +103,100 | 0.00 | 0.66 | +0.66 | buy |
| Legal & General Group Plc | 98,256 | 101,693 | +3,437 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 87,435 | 95,032 | +7,597 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 92,628 | +92,628 | 0.00 | 0.11 | +0.11 | buy |
| Exome Asset Management LLC | 166,944 | 88,024 | -78,920 | 1.81 | 1.41 | -0.40 | sell |
| UBS Group AG | 209,750 | 85,178 | -124,572 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 149,451 | 82,665 | -66,786 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 0 | 69,240 | +69,240 | 0.00 | 0.10 | +0.10 | buy |
| D. E. Shaw & Co., Inc. | 15,764 | 64,389 | +48,625 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 40,684 | 63,301 | +22,617 | 0.20 | 0.38 | +0.18 | buy |
| Trexquant Investment LP | 151,352 | 62,310 | -89,042 | 0.02 | 0.02 | -0.01 | sell |
| TUDOR INVESTMENT CORP ET AL | 50,851 | 57,810 | +6,959 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 72,144 | 57,444 | -14,700 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 296,766 | 53,666 | -243,100 | 0.63 | 0.13 | -0.50 | sell |
| Aberdeen Group plc | 119,389 | 53,574 | -65,815 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 29,670 | 29,670 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 50,100 | 26,656 | -23,444 | 0.06 | 0.05 | -0.01 | sell |
| Campbell & CO Investment Adviser LLC | 16,619 | 25,845 | +9,226 | 0.01 | 0.05 | +0.03 | buy |
| JANE STREET GROUP, LLC | 94,365 | 24,091 | -70,274 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 0 | 23,586 | +23,586 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 41,900 | 21,319 | -20,581 | 0.02 | 0.01 | -0.00 | sell |
| Squarepoint Ops LLC | 39,760 | 19,413 | -20,347 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 18,761 | +18,761 | 0.00 | 0.04 | +0.04 | buy |
| Meridian Wealth Partners, LLC | 38,101 | 18,101 | -20,000 | 0.07 | 0.06 | -0.01 | sell |
| OMERS ADMINISTRATION Corp | 55,200 | 17,500 | -37,700 | 0.01 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 19,181 | 16,816 | -2,365 | 0.02 | 0.03 | +0.01 | sell |
| Pictet Asset Management Holding SA | 0 | 13,869 | +13,869 | 0.00 | 0.00 | +0.00 | buy |
| Atria Investments, Inc | 13,929 | 13,518 | -411 | 0.00 | 0.00 | +0.00 | sell |
| J. Goldman & Co LP | 33,184 | 13,105 | -20,079 | 0.01 | 0.01 | -0.00 | sell |
| Coastal Bridge Advisors, LLC | 19,653 | 13,102 | -6,551 | 0.02 | 0.02 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 7,810 | 9,451 | +1,641 | 0.03 | 0.07 | +0.03 | buy |
| DnB Asset Management AS | 0 | 8,988 | +8,988 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 8,727 | +8,727 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 6,690 | +6,690 | 0.00 | 0.03 | +0.03 | buy |