| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 475,600 | 2,060,100 | +1,584,500 | 0.54 | 2.62 | +2.08 | buy |
| Artal Group S.A. | 0 | 1,012,500 | +1,012,500 | 0.00 | 0.27 | +0.27 | buy |
| ExodusPoint Capital Management, LP | 0 | 296,886 | +296,886 | 0.00 | 0.03 | +0.03 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 289,381 | +289,381 | 0.00 | 0.03 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 832,348 | 1,115,817 | +283,469 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 957,951 | 1,214,050 | +256,099 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 694,885 | 875,765 | +180,880 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 53,100 | 185,600 | +132,500 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 100,804 | +100,804 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,830,500 | 2,896,128 | +65,628 | 0.04 | 0.05 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 337,544 | 381,083 | +43,539 | 0.09 | 0.12 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 42,487 | +42,487 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 14,354 | +14,354 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 14,300 | +14,300 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 10,650 | 24,731 | +14,081 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 12,629 | +12,629 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 10,630 | +10,630 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 6,000 | +6,000 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 1,357 | 6,394 | +5,037 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 11,600 | 16,500 | +4,900 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 4,824 | +4,824 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 31,833 | 33,539 | +1,706 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 69 | 1,311 | +1,242 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 656 | 999 | +343 | 0.00 | 0.00 | +0.00 | buy |
| CALDWELL SUTTER CAPITAL, INC. | 0 | 172 | +172 | 0.00 | 0.00 | +0.00 | buy |
| Spire Wealth Management | 0 | 70 | +70 | 0.00 | 0.00 | +0.00 | buy |
| GENERAL ATLANTIC, L.P. | 9,681,818 | 9,681,818 | 0 | 0.97 | 1.11 | +0.14 | hold |
| ADIRONDACK TRUST CO | 925 | 925 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 186,310 | 186,310 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 31,300 | 31,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 125,157 | 125,157 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 211 | 211 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cormorant Asset Management, LP | 561,600 | 561,600 | 0 | 0.21 | 0.21 | +0.00 | hold |
| EcoR1 Capital, LLC | 5,618,779 | 5,618,779 | 0 | 1.24 | 1.16 | -0.08 | hold |
| Point72 Asset Management, L.P. | 1,840,482 | 1,840,482 | 0 | 0.04 | 0.04 | +0.00 | hold |
| Compagnie Lombard Odier SCmA | 5,820 | 5,820 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 19,963,157 | 19,963,157 | 0 | 41.24 | 53.64 | +12.41 | hold |
| Global Retirement Partners, LLC | 700 | 700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vida Ventures Advisors, LLC | 3,931,818 | 3,931,818 | 0 | 39.38 | 37.26 | -2.12 | hold |
| TCG Crossover Management, LLC | 2,040,816 | 2,040,816 | 0 | 1.94 | 1.80 | -0.14 | hold |
| Tanager Wealth Management LLP | 696,096 | 696,096 | 0 | 0.93 | 1.01 | +0.07 | hold |
| BARCLAYS PLC | 6,400 | 6,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 2,787,194 | 2,787,194 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NBC SECURITIES, INC. | 138 | 138 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,021 | 63,021 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 3,066 | 2,303 | -763 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,549,134 | 2,539,464 | -9,670 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 51,943 | 37,030 | -14,913 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 210,204 | 140,856 | -69,348 | 0.02 | 0.01 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 1,018,091 | 795,729 | -222,362 | 2.15 | 1.26 | -0.89 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 323,349 | 38,138 | -285,211 | 1.52 | 0.17 | -1.35 | sell |
| Kynam Capital Management, LP | 730,472 | 442,704 | -287,768 | 0.79 | 0.40 | -0.39 | sell |
| BVF INC/IL | 9,103,054 | 8,774,570 | -328,484 | 1.59 | 1.75 | +0.16 | sell |
| Sio Capital Management, LLC | 756,891 | 0 | -756,891 | 1.52 | 0.00 | -1.52 | sell |