| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,294,864 | 4,909,487 | +3,614,623 | 0.01 | 0.04 | 0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,195,000 | 5,119,027 | +924,027 | 0.12 | 0.15 | +0.03 | buy |
| Commodore Capital LP | 1,350,000 | 2,218,425 | +868,425 | 1.35 | 2.72 | +1.37 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,679,021 | 5,364,392 | +685,371 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 549,212 | 1,227,178 | +677,966 | 0.06 | 0.22 | 0.00 | buy |
| STEMPOINT CAPITAL LP | 83,662 | 641,964 | +558,302 | 0.40 | 2.70 | +2.30 | buy |
| LORD, ABBETT & CO. LLC | 269,205 | 440,495 | +171,290 | 0.01 | 0.02 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 23,302 | 154,027 | +130,725 | 0.06 | 0.53 | +0.47 | buy |
| Affinity Asset Advisors, LLC | 965,612 | 1,095,924 | +130,312 | 2.40 | 2.87 | +0.47 | buy |
| PFM Health Sciences, LP | 269,158 | 371,766 | +102,608 | 0.24 | 0.39 | +0.14 | buy |
| TD ASSET MANAGEMENT INC | 558,714 | 641,714 | +83,000 | 0.01 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 6,282,290 | 6,349,220 | +66,930 | 2.13 | 2.93 | +0.81 | buy |
| Woodline Partners LP | 516,379 | 545,645 | +29,266 | 0.07 | 0.06 | -0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 93,658 | 71,947 | +21,711 | 0.13 | 0.10 | 0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 177,553 | 190,451 | +12,898 | 0.01 | 0.02 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,593 | 18,909 | +5,316 | 0.02 | 0.03 | +0.01 | buy |
| CALDWELL SUTTER CAPITAL, INC. | 86 | 43 | -43 | 0.00 | 0.00 | -0.00 | sell |
| Harbour Capital Advisors, LLC | 16,675 | 16,375 | -300 | 0.06 | 0.06 | +0.00 | sell |
| Exome Asset Management LLC | 138,152 | 137,716 | -436 | 1.49 | 1.74 | +0.24 | sell |
| HighMark Wealth Management LLC | 167,135 | 166,135 | -1,000 | 1.46 | 1.60 | +0.14 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 36,900 | 35,800 | -1,100 | 0.05 | 0.05 | +0.00 | sell |
| Advisors Preferred, LLC | 4,555 | 2,372 | -2,183 | 0.01 | 0.01 | -0.01 | sell |
| VIRTUS ADVISERS, LLC | 9,285 | 4,214 | -5,071 | 0.07 | 0.03 | -0.04 | sell |
| Rathbones Group PLC | 30,400 | 16,650 | -13,750 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 2,012,052 | 1,993,052 | -19,000 | 5.15 | 5.68 | +0.53 | sell |
| Blue Owl Capital Holdings LP | 255,000 | 220,000 | -35,000 | 0.79 | 0.85 | +0.06 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 429,701 | 370,278 | -59,423 | 0.31 | 0.36 | +0.05 | sell |
| Ally Bridge Group (NY) LLC | 309,614 | 244,538 | -65,076 | 2.65 | 3.51 | +0.86 | sell |
| DAFNA Capital Management LLC | 120,351 | 47,453 | -72,898 | 0.45 | 0.20 | -0.25 | sell |
| First Light Asset Management, LLC | 5,940,132 | 5,805,184 | -134,948 | 7.90 | 9.30 | +1.40 | sell |
| T. Rowe Price Investment Management, Inc. | 3,556,023 | 3,418,600 | -137,423 | 0.03 | 0.04 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 744,592 | 598,952 | -145,640 | 2.68 | 2.24 | -0.44 | sell |
| Siren, L.L.C. | 3,258,677 | 3,004,677 | -254,000 | 2.61 | 2.22 | -0.38 | sell |
| 5AM Venture Management, LLC | 1,285,000 | 830,945 | -454,055 | 4.25 | 3.32 | -0.92 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,161,728 | 1,598,183 | -563,545 | 0.30 | 0.22 | -0.08 | sell |
| Avidity Partners Management LP | 2,132,000 | 1,165,800 | -966,200 | 1.74 | 1.95 | +0.21 | sell |