| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Medicxi Ventures Management (Jersey) Ltd | 19,963,157 | 19,963,157 | 0 | 60.35 | 63.20 | +2.85 | hold |
| GENERAL ATLANTIC, L.P. | 9,681,818 | 9,681,818 | 0 | 4.40 | 5.77 | +1.37 | hold |
| PERCEPTIVE ADVISORS LLC | 6,282,290 | 6,349,220 | +66,930 | 2.16 | 2.96 | +0.81 | buy |
| First Light Asset Management, LLC | 5,940,132 | 5,805,184 | -134,948 | 7.90 | 9.30 | +1.40 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,679,021 | 5,364,392 | +685,371 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,195,000 | 5,119,027 | +924,027 | 0.12 | 0.15 | +0.03 | buy |
| JANUS HENDERSON GROUP PLC | 1,294,864 | 4,909,487 | +3,614,623 | 0.01 | 0.04 | +0.03 | buy |
| Vida Ventures Advisors, LLC | 3,931,818 | 3,931,818 | 0 | 45.36 | 45.01 | -0.35 | hold |
| FMR LLC | 2,916,494 | 3,651,594 | +735,100 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 2,814,318 | 3,498,709 | +684,391 | 0.25 | 0.31 | +0.06 | buy |
| Point72 Asset Management, L.P. | 2,715,663 | 3,426,599 | +710,936 | 0.15 | 0.16 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 3,556,023 | 3,418,600 | -137,423 | 0.03 | 0.04 | +0.00 | sell |
| Siren, L.L.C. | 3,258,677 | 3,004,677 | -254,000 | 2.61 | 2.22 | -0.38 | sell |
| TCG Crossover Management, LLC | 2,890,816 | 2,890,816 | 0 | 3.92 | 4.73 | +0.82 | hold |
| Cormorant Asset Management, LP | 2,561,600 | 2,561,600 | 0 | 2.17 | 2.36 | +0.18 | hold |
| FRANKLIN RESOURCES INC | 2,302,546 | 2,308,546 | +6,000 | 0.01 | 0.01 | +0.00 | buy |
| Commodore Capital LP | 1,350,000 | 2,218,425 | +868,425 | 1.35 | 2.72 | +1.37 | buy |
| Octagon Capital Advisors LP | 2,012,052 | 1,993,052 | -19,000 | 5.15 | 5.68 | +0.53 | sell |
| MORGAN STANLEY | 1,379,651 | 1,924,509 | +544,858 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,161,728 | 1,598,183 | -563,545 | 0.30 | 0.22 | -0.08 | sell |
| Deep Track Capital, LP | 1,350,000 | 1,350,000 | 0 | 0.69 | 0.85 | +0.16 | hold |
| BAKER BROS. ADVISORS LP | 1,227,178 | 1,227,178 | 0 | 0.20 | 0.22 | +0.02 | hold |
| Avidity Partners Management LP | 2,132,000 | 1,165,800 | -966,200 | 1.74 | 1.95 | +0.21 | sell |
| Affinity Asset Advisors, LLC | 965,612 | 1,095,924 | +130,312 | 2.40 | 2.87 | +0.47 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,139,546 | 1,079,708 | -59,838 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 0 | 1,070,209 | +1,070,209 | 0.00 | 0.00 | +0.00 | buy |
| 5AM Venture Management, LLC | 1,285,000 | 830,945 | -454,055 | 4.25 | 3.32 | -0.92 | sell |
| Tanager Wealth Management LLP | 696,096 | 696,096 | 0 | 1.50 | 1.51 | +0.01 | hold |
| STEMPOINT CAPITAL LP | 83,662 | 641,964 | +558,302 | 0.40 | 2.70 | +2.30 | buy |
| TD ASSET MANAGEMENT INC | 558,714 | 641,714 | +83,000 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 587,518 | 625,316 | +37,798 | 0.01 | 0.01 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 744,592 | 598,952 | -145,640 | 2.68 | 2.24 | -0.44 | sell |
| Woodline Partners LP | 516,379 | 545,645 | +29,266 | 0.07 | 0.06 | -0.01 | buy |
| Nantahala Capital Management, LLC | 512,647 | 512,647 | 0 | 0.69 | 0.60 | -0.09 | hold |
| BlackRock, Inc. | 559,720 | 500,924 | -58,796 | 0.00 | 0.00 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 269,205 | 440,495 | +171,290 | 0.01 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 230,379 | 398,451 | +168,072 | 0.00 | 0.01 | +0.00 | buy |
| PFM Health Sciences, LP | 269,158 | 371,766 | +102,608 | 0.25 | 0.47 | +0.23 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 429,701 | 370,278 | -59,423 | 0.31 | 0.36 | +0.05 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 365,200 | +365,200 | 0.00 | 0.04 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 264,969 | 317,329 | +52,360 | 0.00 | 0.00 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 303,479 | +303,479 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 170,951 | 261,184 | +90,233 | 0.03 | 0.05 | +0.02 | buy |
| Ally Bridge Group (NY) LLC | 309,614 | 244,538 | -65,076 | 2.65 | 3.51 | +0.86 | sell |
| Blue Owl Capital Holdings LP | 255,000 | 220,000 | -35,000 | 0.79 | 0.85 | +0.06 | sell |
| FRED ALGER MANAGEMENT, LLC | 177,553 | 190,451 | +12,898 | 0.01 | 0.02 | +0.00 | buy |
| JPMORGAN CHASE & CO | 135,903 | 190,385 | +54,482 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 209,600 | 178,600 | -31,000 | 0.01 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 13,055 | 175,566 | +162,511 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 681,421 | 175,428 | -505,993 | 0.03 | 0.01 | -0.02 | sell |
| HighMark Wealth Management LLC | 167,135 | 166,135 | -1,000 | 1.46 | 1.60 | +0.14 | sell |
| J. Goldman & Co LP | 0 | 164,703 | +164,703 | 0.00 | 0.10 | +0.10 | buy |
| ADAR1 Capital Management, LLC | 23,302 | 154,027 | +130,725 | 0.06 | 0.53 | +0.47 | buy |
| Cutter Capital Management, LP | 0 | 147,076 | +147,076 | 0.00 | 1.01 | +1.01 | buy |
| MARSHALL WACE, LLP | 180,853 | 139,732 | -41,121 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 138,152 | 137,716 | -436 | 1.49 | 1.74 | +0.24 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 100,613 | 115,107 | +14,494 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 96,515 | 107,058 | +10,543 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 80,380 | 80,380 | 0 | 0.36 | 0.54 | +0.18 | hold |
| Ensign Peak Advisors, Inc | 79,000 | 79,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 0 | 75,451 | +75,451 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 73,189 | +73,189 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 93,658 | 71,947 | -21,711 | 0.11 | 0.09 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 56,597 | 57,257 | +660 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 50,000 | 50,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| STATE STREET CORP | 48,592 | 48,106 | -486 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 120,351 | 47,453 | -72,898 | 0.45 | 0.20 | -0.25 | sell |
| HighVista Strategies LLC | 46,116 | 46,116 | 0 | 0.25 | 0.29 | +0.03 | hold |
| Cubist Systematic Strategies, LLC | 134,120 | 45,885 | -88,235 | 0.03 | 0.01 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 313,338 | 43,708 | -269,630 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 41,900 | +41,900 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 103,908 | 37,900 | -66,008 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 0 | 36,195 | +36,195 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 36,900 | 35,800 | -1,100 | 0.05 | 0.05 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 29,670 | +29,670 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 20,121 | 26,806 | +6,685 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 49,111 | 25,700 | -23,411 | 0.02 | 0.01 | -0.01 | sell |
| XTX Topco Ltd | 10,174 | 22,680 | +12,506 | 0.01 | 0.03 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 19,122 | +19,122 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,593 | 18,909 | +5,316 | 0.02 | 0.03 | +0.01 | buy |
| Lynx1 Capital Management LP | 17,400 | 17,400 | 0 | 0.10 | 0.11 | +0.01 | hold |
| Atom Investors LP | 0 | 17,197 | +17,197 | 0.00 | 0.04 | +0.04 | buy |
| Rathbones Group PLC | 30,400 | 16,650 | -13,750 | 0.00 | 0.00 | -0.00 | sell |
| Harbour Capital Advisors, LLC | 16,675 | 16,375 | -300 | 0.06 | 0.06 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 27,884 | 15,746 | -12,138 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 0 | 14,269 | +14,269 | 0.00 | 0.06 | +0.06 | buy |
| Atria Investments, Inc | 17,134 | 13,774 | -3,360 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 0 | 10,200 | +10,200 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 9,672 | +9,672 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 6,279 | 8,343 | +2,064 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 350 | 5,302 | +4,952 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 9,285 | 4,214 | -5,071 | 0.07 | 0.03 | -0.04 | sell |
| GAMMA Investing LLC | 2,972 | 3,837 | +865 | 0.00 | 0.01 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,556 | 2,972 | +416 | 0.00 | 0.00 | +0.00 | buy |
| Advisors Preferred, LLC | 4,555 | 2,372 | -2,183 | 0.01 | 0.01 | -0.01 | sell |
| Tower Research Capital LLC (TRC) | 2,289 | 1,861 | -428 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,199 | 1,813 | -386 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,457 | +1,457 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 14,094 | 1,179 | -12,915 | 0.00 | 0.00 | -0.00 | sell |
| ADIRONDACK TRUST CO | 925 | 925 | 0 | 0.01 | 0.01 | +0.00 | hold |