| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 10,808,080 | 14,555,555 | +3,747,475 | 3.39 | 3.58 | +0.19 | buy |
| EcoR1 Capital, LLC | 550,000 | 3,115,000 | +2,565,000 | 0.64 | 3.53 | +2.89 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 10,035,000 | 11,281,741 | +1,246,741 | 0.39 | 0.43 | +0.04 | buy |
| TCG Crossover Management, LLC | 3,136,480 | 4,286,480 | +1,150,000 | 3.74 | 3.55 | -0.19 | buy |
| Siren, L.L.C. | 3,227,517 | 4,027,517 | +800,000 | 3.06 | 3.00 | -0.06 | buy |
| STEMPOINT CAPITAL LP | 655,385 | 1,154,114 | +498,729 | 3.20 | 4.95 | +1.75 | buy |
| Capital World Investors | 684,805 | 1,158,699 | +473,894 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 141,238 | 458,203 | +316,965 | 0.50 | 1.66 | +1.16 | buy |
| Rock Springs Capital Management LP | 69,240 | 324,015 | +254,775 | 0.10 | 0.42 | +0.32 | buy |
| ARMISTICE CAPITAL, LLC | 378,000 | 500,000 | +122,000 | 0.14 | 0.15 | +0.01 | buy |
| ROYCE & ASSOCIATES LP | 247,387 | 362,873 | +115,486 | 0.06 | 0.09 | +0.03 | buy |
| Candriam S.C.A. | 343,207 | 395,623 | +52,416 | 0.04 | 0.05 | +0.01 | buy |
| Foresite Capital Management VI LLC | 1,314,019 | 1,364,019 | +50,000 | 12.31 | 10.31 | -2.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,096,704 | 1,129,758 | +33,054 | 0.01 | 0.02 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 18,761 | 33,104 | +14,343 | 0.04 | 0.08 | 0.00 | buy |
| DnB Asset Management AS | 8,988 | 12,746 | +3,758 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 20 | 1,536 | +1,516 | 0.00 | 0.00 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 13,102 | 14,033 | +931 | 0.02 | 0.03 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 9,451 | 10,034 | +583 | 0.07 | 0.07 | +0.00 | buy |
| Aspect Partners, LLC | 230 | 195 | -35 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 2,064 | 1,895 | -169 | 0.00 | 0.00 | -0.00 | sell |
| HighMark Wealth Management LLC | 237,285 | 236,785 | -500 | 2.53 | 2.41 | -0.12 | sell |
| China Universal Asset Management Co., Ltd. | 16,816 | 15,721 | -1,095 | 0.03 | 0.03 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 53,666 | 38,566 | -15,100 | 0.13 | 0.07 | -0.06 | sell |
| HighVista Strategies LLC | 63,301 | 44,490 | -18,811 | 0.38 | 0.29 | -0.09 | sell |
| Cinctive Capital Management LP | 92,628 | 72,831 | -19,797 | 0.11 | 0.11 | -0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 190,360 | 162,147 | -28,213 | 0.02 | 0.02 | -0.00 | sell |
| Blue Owl Capital Holdings LP | 169,450 | 139,450 | -30,000 | 1.28 | 1.08 | -0.20 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 186,399 | 155,101 | -31,298 | 0.29 | 0.90 | +0.60 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 116,397 | 81,525 | -34,872 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 666,196 | 591,601 | -74,595 | 1.24 | 1.48 | +0.23 | sell |
| Octagon Capital Advisors LP | 830,000 | 750,000 | -80,000 | 3.14 | 2.35 | -0.79 | sell |
| TD ASSET MANAGEMENT INC | 466,960 | 376,344 | -90,616 | 0.01 | 0.01 | -0.00 | sell |
| 5AM Venture Management, LLC | 680,945 | 580,945 | -100,000 | 6.05 | 4.57 | -1.48 | sell |
| Nantahala Capital Management, LLC | 404,803 | 254,803 | -150,000 | 0.34 | 0.21 | -0.13 | sell |
| PERCEPTIVE ADVISORS LLC | 3,100,902 | 2,917,634 | -183,268 | 2.17 | 1.30 | -0.87 | sell |
| Logos Global Management LP | 525,000 | 200,000 | -325,000 | 1.26 | 0.33 | -0.92 | sell |
| Saturn V Capital Management LP | 734,539 | 282,692 | -451,847 | 3.91 | 1.30 | -2.61 | sell |
| RTW INVESTMENTS, LP | 2,291,747 | 1,790,837 | -500,910 | 0.68 | 0.45 | -0.24 | sell |
| Affinity Asset Advisors, LLC | 1,107,162 | 600,552 | -506,610 | 2.50 | 1.08 | -1.42 | sell |
| Cormorant Asset Management, LP | 1,925,000 | 1,325,000 | -600,000 | 3.22 | 1.53 | -1.69 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,804,056 | 3,927,343 | -876,713 | 0.01 | 0.01 | -0.00 | sell |
| First Light Asset Management, LLC | 3,635,816 | 2,278,940 | -1,356,876 | 8.31 | 4.36 | -3.95 | sell |
| Commodore Capital LP | 2,850,000 | 1,000,000 | -1,850,000 | 3.37 | 1.66 | -1.71 | sell |
| GENERAL ATLANTIC, L.P. | 9,681,818 | 6,117,715 | -3,564,103 | 7.05 | 5.33 | -1.72 | sell |