| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 10,808,080 | 14,555,555 | +3,747,475 | 3.39 | 3.58 | +0.19 | buy |
| FMR LLC | 6,277,243 | 8,961,939 | +2,684,696 | 0.01 | 0.01 | +0.00 | buy |
| EcoR1 Capital, LLC | 550,000 | 3,115,000 | +2,565,000 | 0.64 | 3.56 | +2.92 | buy |
| BRAIDWELL LP | 0 | 2,188,320 | +2,188,320 | 0.00 | 1.75 | +1.75 | buy |
| Deep Track Capital, LP | 0 | 2,000,000 | +2,000,000 | 0.00 | 1.14 | +1.14 | buy |
| MAVERICK CAPITAL LTD | 0 | 1,643,724 | +1,643,724 | 0.00 | 0.44 | +0.44 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 10,035,000 | 11,281,741 | +1,246,741 | 0.39 | 0.43 | +0.04 | buy |
| TCG Crossover Management, LLC | 3,136,480 | 4,286,480 | +1,150,000 | 3.74 | 3.55 | -0.19 | buy |
| Sofinnova Investments, Inc. | 0 | 1,104,274 | +1,104,274 | 0.00 | 1.19 | +1.19 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 4,331,318 | 5,377,068 | +1,045,750 | 0.59 | 0.70 | +0.11 | buy |
| MILLENNIUM MANAGEMENT LLC | 902,268 | 1,870,671 | +968,403 | 0.02 | 0.03 | +0.02 | buy |
| Siren, L.L.C. | 3,227,517 | 4,027,517 | +800,000 | 3.06 | 3.00 | -0.06 | buy |
| D. E. Shaw & Co., Inc. | 64,389 | 831,636 | +767,247 | 0.00 | 0.02 | +0.01 | buy |
| Jain Global LLC | 241,975 | 915,803 | +673,828 | 0.08 | 0.22 | +0.15 | buy |
| BAKER BROS. ADVISORS LP | 0 | 670,751 | +670,751 | 0.00 | 0.10 | +0.10 | buy |
| FEDERATED HERMES, INC. | 1,749,650 | 2,342,139 | +592,489 | 0.07 | 0.10 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 247,555 | 779,001 | +531,446 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 655,385 | 1,154,114 | +498,729 | 3.20 | 4.95 | +1.75 | buy |
| Capital World Investors | 684,805 | 1,158,699 | +473,894 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 107,671 | 578,251 | +470,580 | 0.01 | 0.06 | +0.04 | buy |
| JANE STREET GROUP, LLC | 24,091 | 480,204 | +456,113 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 85,178 | 537,518 | +452,340 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 441,160 | +441,160 | 0.00 | 0.06 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 553,007 | 949,544 | +396,537 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 137,201 | 519,962 | +382,761 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 378,740 | +378,740 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 348,279 | +348,279 | 0.00 | 0.03 | +0.03 | buy |
| SummitTX Capital, L.P. | 0 | 332,708 | +332,708 | 0.00 | 0.25 | +0.25 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 141,238 | 458,203 | +316,965 | 0.50 | 1.66 | +1.16 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 257,190 | +257,190 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 69,240 | 324,015 | +254,775 | 0.10 | 0.42 | +0.32 | buy |
| SG Americas Securities, LLC | 23,586 | 263,625 | +240,039 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 408,386 | 592,604 | +184,218 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 108,002 | 280,120 | +172,118 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 156,205 | +156,205 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 150,000 | +150,000 | 0.00 | 0.25 | +0.25 | buy |
| ARMISTICE CAPITAL, LLC | 378,000 | 500,000 | +122,000 | 0.29 | 0.31 | +0.02 | buy |
| ROYCE & ASSOCIATES LP | 247,387 | 362,873 | +115,486 | 0.06 | 0.09 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 164,600 | 279,300 | +114,700 | 0.01 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 113,590 | 216,130 | +102,540 | 0.00 | 0.01 | +0.00 | buy |
| Holocene Advisors, LP | 0 | 101,597 | +101,597 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 0 | 100,000 | +100,000 | 0.00 | 0.23 | +0.23 | buy |
| DIADEMA PARTNERS LP | 0 | 90,000 | +90,000 | 0.00 | 1.34 | +1.34 | buy |
| Trexquant Investment LP | 62,310 | 146,523 | +84,213 | 0.02 | 0.03 | +0.02 | buy |
| XTX Topco Ltd | 0 | 79,077 | +79,077 | 0.00 | 0.05 | +0.05 | buy |
| Voleon Capital Management LP | 0 | 79,074 | +79,074 | 0.00 | 0.04 | +0.04 | buy |
| Aquatic Capital Management LLC | 0 | 69,755 | +69,755 | 0.00 | 0.05 | +0.05 | buy |
| TUDOR INVESTMENT CORP ET AL | 57,810 | 121,810 | +64,000 | 0.01 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 19,413 | 81,812 | +62,399 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 343,207 | 395,623 | +52,416 | 0.04 | 0.05 | +0.01 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.10 | +0.10 | buy |
| Foresite Capital Management VI LLC | 1,314,019 | 1,364,019 | +50,000 | 12.31 | 10.31 | -2.00 | buy |
| Persistent Asset Partners Ltd | 0 | 43,266 | +43,266 | 0.00 | 0.52 | +0.52 | buy |
| B. Metzler seel. Sohn & Co. AG | 0 | 38,432 | +38,432 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,096,704 | 1,129,758 | +33,054 | 0.01 | 0.01 | +0.00 | buy |
| Atom Investors LP | 0 | 18,347 | +18,347 | 0.00 | 0.04 | +0.04 | buy |
| GSA CAPITAL PARTNERS LLP | 18,761 | 33,104 | +14,343 | 0.04 | 0.07 | +0.03 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 12,569 | +12,569 | 0.00 | 0.07 | +0.07 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 11,563 | +11,563 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 11,441 | +11,441 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 21,319 | 32,508 | +11,189 | 0.01 | 0.02 | +0.01 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 11,166 | +11,166 | 0.00 | 0.10 | +0.10 | buy |
| HRT FINANCIAL LP | 0 | 11,020 | +11,020 | 0.00 | 0.00 | +0.00 | buy |
| Sigma Planning Corp | 0 | 9,000 | +9,000 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 8,496 | +8,496 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 0 | 4,000 | +4,000 | 0.00 | 0.05 | +0.05 | buy |
| DnB Asset Management AS | 8,988 | 12,746 | +3,758 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 101,693 | 105,427 | +3,734 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 3,218 | +3,218 | 0.00 | 0.02 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 20 | 1,536 | +1,516 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,198 | 2,446 | +1,248 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 1,003 | +1,003 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,709 | 4,688 | +979 | 0.00 | 0.00 | +0.00 | buy |
| Coastal Bridge Advisors, LLC | 13,102 | 14,033 | +931 | 0.02 | 0.03 | +0.00 | buy |
| CITIGROUP INC | 1,844 | 2,691 | +847 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 9,451 | 10,034 | +583 | 0.07 | 0.07 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 422 | +422 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 275 | +275 | 0.00 | 0.00 | +0.00 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 174 | +174 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 5,404 | 5,572 | +168 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 0 | 99 | +99 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| SageView Advisory Group, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 21 | 25 | +4 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 3,612 | 3,615 | +3 | 0.00 | 0.00 | -0.00 | buy |
| ADIRONDACK TRUST CO | 925 | 925 | 0 | 0.01 | 0.01 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 29,670 | 29,670 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 57,444 | 57,444 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 294 | 294 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Medicxi Ventures Management (Jersey) Ltd | 19,963,157 | 19,963,157 | 0 | 65.03 | 59.80 | -5.24 | hold |
| Steward Partners Investment Advisory, LLC | 81 | 81 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 3,468 | 3,468 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Meridian Wealth Partners, LLC | 18,101 | 18,101 | 0 | 0.06 | 0.06 | +0.00 | hold |
| BELLEVUE ASSET MANAGEMENT, LLC | 70 | 70 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Eagle Health Investments LP | 103,100 | 103,100 | 0 | 0.66 | 0.57 | -0.09 | hold |
| Index Venture Life Associates VI Ltd | 9,961,789 | 9,961,789 | 0 | 100.00 | 100.00 | 0.00 | hold |
| EverSource Wealth Advisors, LLC | 20 | 7 | -13 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL SECURITIES, INC. | 17 | 0 | -17 | 0.00 | 0.00 | -0.00 | sell |