| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 17,754,430 | +17,754,430 | 0.00 | 0.43 | +0.43 | buy |
| TCG Crossover Management, LLC | 0 | 17,754,430 | +17,754,430 | 0.00 | 1.12 | +1.12 | buy |
| Versant Venture Management, LLC | 0 | 12,166,109 | +12,166,109 | 0.00 | 19.44 | +19.44 | buy |
| Deep Track Capital, LP | 0 | 9,487,745 | +9,487,745 | 0.00 | 0.44 | +0.44 | buy |
| RTW INVESTMENTS, LP | 0 | 8,695,652 | +8,695,652 | 0.00 | 0.20 | +0.20 | buy |
| VR Adviser, LLC | 0 | 8,695,652 | +8,695,652 | 0.00 | 0.73 | +0.73 | buy |
| Commodore Capital LP | 0 | 8,695,652 | +8,695,652 | 0.00 | 1.14 | +1.14 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 5,017,733 | +5,017,733 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 610,387 | 4,667,063 | +4,056,676 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 0 | 3,043,478 | +3,043,478 | 0.00 | 0.03 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,838,700 | 3,789,538 | +1,950,838 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 0 | 1,304,347 | +1,304,347 | 0.00 | 0.17 | +0.17 | buy |
| BlackRock, Inc. | 601,866 | 1,524,422 | +922,556 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,495,916 | 2,371,430 | +875,514 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 456,115 | 1,301,664 | +845,549 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 673,584 | +673,584 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 127,443 | 386,723 | +259,280 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 226,687 | +226,687 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 210,482 | +210,482 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 105,052 | 230,820 | +125,768 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1 | 120,232 | +120,231 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 119,504 | +119,504 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 96,641 | +96,641 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 79,415 | +79,415 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 62,109 | +62,109 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 58,742 | +58,742 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 55,183 | +55,183 | 0.00 | 0.00 | +0.00 | buy |
| Cannon Global Investment Management, LLC | 0 | 49,000 | +49,000 | 0.00 | 0.27 | +0.27 | buy |
| OMERS ADMINISTRATION Corp | 0 | 47,800 | +47,800 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 32,987 | +32,987 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 12,897 | +12,897 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 15,333 | 22,518 | +7,185 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 2,397 | 9,028 | +6,631 | 0.00 | 0.00 | +0.00 | buy |
| Quadrant Private Wealth Management, LLC | 15,286 | 20,022 | +4,736 | 0.00 | 0.01 | +0.00 | buy |
| Point72 Asset Management, L.P. | 5,961,631 | 5,964,678 | +3,047 | 0.01 | 0.02 | +0.01 | buy |
| Farther Finance Advisors, LLC | 0 | 2,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 407 | +407 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 294 | +294 | 0.00 | 0.00 | +0.00 | buy |
| HARBOURVEST PARTNERS LLC | 29,018 | 29,018 | 0 | 0.02 | 0.06 | +0.05 | hold |
| Advisors Asset Management, Inc. | 8,313 | 8,313 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Casdin Capital, LLC | 1,228,190 | 1,228,190 | 0 | 0.08 | 0.21 | +0.13 | hold |
| Parametrica Management Ltd | 27,840 | 27,840 | 0 | 0.04 | 0.07 | +0.03 | hold |
| Arax Advisory Partners | 99 | 99 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 77,797 | 77,797 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Syncona Portfolio Ltd | 1,213,056 | 1,213,056 | 0 | 3.52 | 10.66 | +7.15 | hold |
| Optiver Holding B.V. | 32 | 32 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Smartleaf Asset Management LLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RAYMOND JAMES FINANCIAL INC | 91,323 | 91,323 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 883 | 883 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 1,447 | 1,418 | -29 | 0.00 | 0.00 | +0.00 | sell |
| SBI Securities Co., Ltd. | 1,530 | 1,260 | -270 | 0.00 | 0.00 | +0.00 | sell |
| Scientech Research LLC | 12,355 | 0 | -12,355 | 0.01 | 0.00 | -0.01 | sell |
| PRUDENTIAL FINANCIAL INC | 59,800 | 25,300 | -34,500 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 71,540 | 8,779 | -62,761 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 76,800 | 0 | -76,800 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 333,199 | 76,836 | -256,363 | 0.03 | 0.01 | -0.02 | sell |
| CITADEL ADVISORS LLC | 319,457 | 0 | -319,457 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 462,963 | 119,308 | -343,655 | 0.25 | 0.19 | -0.05 | sell |
| DAFNA Capital Management LLC | 2,793,586 | 2,434,353 | -359,233 | 0.65 | 1.25 | +0.61 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,349,200 | 906,827 | -442,373 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,217,103 | 278,075 | -939,028 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 1,267,700 | 0 | -1,267,700 | 0.00 | 0.00 | -0.00 | sell |