| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 1,524,422 | 8,091,768 | +6,567,346 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 2,146,182 | +2,146,182 | 0.00 | 0.91 | +0.91 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,301,664 | 2,979,529 | +1,677,865 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 386,723 | 1,843,154 | +1,456,431 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 230,820 | 1,593,944 | +1,363,124 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 3,043,478 | 4,257,530 | +1,214,052 | 0.03 | 0.03 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 5,017,733 | 5,522,944 | +505,211 | 0.02 | 0.02 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 378,867 | +378,867 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 906,827 | 1,257,700 | +350,873 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,371,430 | 2,699,013 | +327,583 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 62,109 | 381,419 | +319,310 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 79,415 | 378,867 | +299,452 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 12,897 | 299,014 | +286,117 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 232,409 | +232,409 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 55,183 | 271,492 | +216,309 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 163,592 | +163,592 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 148,915 | +148,915 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 128,404 | +128,404 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 120,234 | +120,234 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 58,742 | 174,062 | +115,320 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 101,164 | +101,164 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 81,900 | +81,900 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 76,271 | +76,271 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 59,056 | +59,056 | 0.00 | 0.02 | +0.02 | buy |
| Spark Investment Management LLC | 0 | 59,000 | +59,000 | 0.00 | 0.28 | +0.28 | buy |
| CITIGROUP INC | 0 | 57,001 | +57,001 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 56,510 | +56,510 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 45,890 | +45,890 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 43,960 | +43,960 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 76,836 | 120,598 | +43,762 | 0.01 | 0.02 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 36,349 | +36,349 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 34,602 | +34,602 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 33,425 | +33,425 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 31,063 | +31,063 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 29,790 | +29,790 | 0.00 | 0.00 | +0.00 | buy |
| Magnus Financial Group LLC | 0 | 25,290 | +25,290 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 24,401 | +24,401 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,418 | 25,563 | +24,145 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 24,067 | +24,067 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 22,700 | +22,700 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 21,532 | +21,532 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 16,137 | +16,137 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 14,101 | +14,101 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 11,769 | +11,769 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 11,267 | +11,267 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 11,185 | +11,185 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Sterling Capital Management LLC | 0 | 2,484 | +2,484 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 2,330 | +2,330 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 1,697 | +1,697 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 32 | 368 | +336 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 8,779 | 8,994 | +215 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 77,797 | 77,830 | +33 | 0.00 | 0.00 | -0.00 | buy |
| Advisors Asset Management, Inc. | 8,313 | 8,315 | +2 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,789,538 | 3,789,538 | 0 | 0.01 | 0.01 | -0.00 | hold |
| HARBOURVEST PARTNERS LLC | 29,018 | 29,018 | 0 | 0.06 | 0.04 | -0.02 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 17,754,430 | 17,754,430 | 0 | 0.43 | 0.38 | -0.05 | hold |
| RTW INVESTMENTS, LP | 8,695,652 | 8,695,652 | 0 | 0.20 | 0.18 | -0.01 | hold |
| Casdin Capital, LLC | 1,228,190 | 1,228,190 | 0 | 0.21 | 0.15 | -0.06 | hold |
| Parametrica Management Ltd | 27,840 | 27,840 | 0 | 0.07 | 0.05 | -0.02 | hold |
| Versant Venture Management, LLC | 12,166,109 | 12,166,109 | 0 | 19.44 | 18.33 | -1.11 | hold |
| Rock Springs Capital Management LP | 1,304,347 | 1,304,347 | 0 | 0.17 | 0.16 | -0.02 | hold |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VR Adviser, LLC | 8,695,652 | 8,695,652 | 0 | 0.73 | 0.65 | -0.09 | hold |
| Quadrant Private Wealth Management, LLC | 20,022 | 20,022 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Commodore Capital LP | 8,695,652 | 8,695,652 | 0 | 1.14 | 1.27 | +0.13 | hold |
| TCG Crossover Management, LLC | 17,754,430 | 17,754,430 | 0 | 1.12 | 1.04 | -0.07 | hold |
| Fortitude Family Office, LLC | 294 | 294 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Smartleaf Asset Management LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RAYMOND JAMES FINANCIAL INC | 91,323 | 91,323 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 883 | 883 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 1,260 | 1,218 | -42 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 99 | 0 | -99 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 407 | 0 | -407 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 2,500 | 0 | -2,500 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 25,300 | 18,595 | -6,705 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 9,028 | 0 | -9,028 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 32,987 | 12,483 | -20,504 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 22,518 | 0 | -22,518 | 0.00 | 0.00 | -0.00 | sell |
| Deep Track Capital, LP | 9,487,745 | 9,462,645 | -25,100 | 0.44 | 0.34 | -0.10 | sell |
| Squarepoint Ops LLC | 119,504 | 90,149 | -29,355 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 2,434,353 | 2,400,458 | -33,895 | 1.25 | 1.12 | -0.13 | sell |
| OMERS ADMINISTRATION Corp | 47,800 | 0 | -47,800 | 0.00 | 0.00 | -0.00 | sell |
| Cannon Global Investment Management, LLC | 49,000 | 0 | -49,000 | 0.27 | 0.00 | -0.27 | sell |
| GOLDMAN SACHS GROUP INC | 210,482 | 150,433 | -60,049 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 120,232 | 24,700 | -95,532 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 96,641 | 0 | -96,641 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 119,308 | 0 | -119,308 | 0.19 | 0.00 | -0.19 | sell |
| MARSHALL WACE, LLP | 673,584 | 537,994 | -135,590 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 226,687 | 0 | -226,687 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 278,075 | 0 | -278,075 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 4,667,063 | 4,194,981 | -472,082 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Asset Management, L.P. | 5,964,678 | 4,980,526 | -984,152 | 0.02 | 0.02 | -0.00 | sell |
| Syncona Portfolio Ltd | 1,213,056 | 0 | -1,213,056 | 10.66 | 0.00 | -10.66 | sell |