| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 0 | 2,269,222 | +2,269,222 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,732,133 | 2,475,215 | +743,082 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 165,500 | 488,200 | +322,700 | 0.00 | 0.00 | +0.00 | buy |
| Syncona Portfolio Ltd | 1,000,771 | 1,213,056 | +212,285 | 2.97 | 2.57 | -0.40 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 166,123 | +166,123 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 211,326 | 352,512 | +141,186 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 119,384 | +119,384 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 105,697 | +105,697 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 157,600 | 257,600 | +100,000 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 71,721 | +71,721 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 779,591 | 836,914 | +57,323 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 16,148 | 61,945 | +45,797 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 70,806 | 108,120 | +37,314 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 935,568 | 968,182 | +32,614 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 10,515 | 34,087 | +23,572 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 20,861 | +20,861 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 0 | 19,028 | +19,028 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 16,081 | +16,081 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,389 | 25,137 | +13,748 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 7,261 | 19,519 | +12,258 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 1,609 | +1,609 | 0.00 | 0.00 | +0.00 | buy |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 24,683 | 25,022 | +339 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 26 | 99 | +73 | 0.00 | 0.00 | 0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 905 | 905 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 17,437 | 17,437 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,324 | 3,324 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 20,020 | 20,020 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 15,150 | 15,150 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,322,751 | 1,322,751 | 0 | 0.01 | 0.00 | -0.00 | hold |
| HARBOURVEST PARTNERS LLC | 29,018 | 29,018 | 0 | 0.04 | 0.03 | -0.01 | hold |
| TANG CAPITAL MANAGEMENT LLC | 900,000 | 900,000 | 0 | 0.23 | 0.11 | -0.12 | hold |
| BAKER BROS. ADVISORS LP | 797,460 | 797,460 | 0 | 0.03 | 0.01 | -0.01 | hold |
| FOUNDERS FINANCIAL SECURITIES LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DAFNA Capital Management LLC | 1,704,232 | 1,704,232 | 0 | 1.04 | 0.69 | -0.35 | hold |
| Parametrica Management Ltd | 27,840 | 27,840 | 0 | 0.09 | 0.06 | -0.04 | hold |
| VR Adviser, LLC | 5,389,259 | 5,389,259 | 0 | 0.88 | 0.48 | -0.39 | hold |
| Bain Capital Life Sciences Investors, LLC | 5,410,361 | 5,410,361 | 0 | 1.51 | 0.96 | -0.55 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 3,976 | 3,976 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14,882 | 14,882 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,743 | 13,743 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 706 | 706 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 78,234 | 78,210 | -24 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 176 | 131 | -45 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 68 | 0 | -68 | 0.00 | 0.00 | 0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 711 | 136 | -575 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 52,466 | 49,862 | -2,604 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 5,842 | 0 | -5,842 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 17,032 | 7,100 | -9,932 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 10,583 | 0 | -10,583 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 20,158 | 0 | -20,158 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 51,015 | 25,978 | -25,037 | 0.02 | 0.01 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 75,315 | 33,449 | -41,866 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 149,000 | 105,994 | -43,006 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 398,380 | 355,331 | -43,049 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 45,160 | 0 | -45,160 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 378,633 | 140,759 | -237,874 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 276,163 | 0 | -276,163 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 2,950,279 | 2,521,511 | -428,768 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 1,333,650 | 666,825 | -666,825 | 0.56 | 0.18 | -0.38 | sell |
| Casdin Capital, LLC | 5,190,506 | 3,212,316 | -1,978,190 | 1.01 | 0.37 | -0.64 | sell |