| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 0 | 5,961,631 | +5,961,631 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 1,704,232 | 2,793,586 | +1,089,354 | 0.21 | 0.65 | +0.44 | buy |
| VANGUARD GROUP INC | 2,103,869 | 2,103,869 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,838,700 | +1,838,700 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 911,446 | 1,495,916 | +584,470 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,586,900 | 1,349,200 | -1,237,700 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 857,600 | 1,267,700 | +410,100 | 0.00 | 0.00 | +0.00 | buy |
| Casdin Capital, LLC | 1,228,190 | 1,228,190 | 0 | 0.05 | 0.08 | +0.02 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 719,808 | 1,217,103 | +497,295 | 0.00 | 0.00 | +0.00 | buy |
| Syncona Portfolio Ltd | 1,213,056 | 1,213,056 | 0 | 2.18 | 3.52 | +1.34 | hold |
| MILLENNIUM MANAGEMENT LLC | 743,781 | 610,387 | -133,394 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 599,656 | 601,866 | +2,210 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 462,963 | 462,963 | 0 | 0.23 | 0.25 | +0.02 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 445,309 | 456,115 | +10,806 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 603,479 | 333,199 | -270,280 | 0.03 | 0.03 | +0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 319,457 | +319,457 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 127,443 | 127,443 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 67,000 | 105,052 | +38,052 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 91,323 | 91,323 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 77,853 | 77,797 | -56 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 76,800 | +76,800 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 192,139 | 71,540 | -120,599 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 59,800 | 59,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOURVEST PARTNERS LLC | 29,018 | 29,018 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Parametrica Management Ltd | 27,840 | 27,840 | 0 | 0.02 | 0.04 | +0.02 | hold |
| XTX Topco Ltd | 27,558 | 15,333 | -12,225 | 0.00 | 0.00 | -0.00 | sell |
| Quadrant Private Wealth Management, LLC | 15,286 | 15,286 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Scientech Research LLC | 0 | 12,355 | +12,355 | 0.00 | 0.01 | +0.01 | buy |
| Advisors Asset Management, Inc. | 8,412 | 8,313 | -99 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 0 | 2,397 | +2,397 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 1,530 | 1,530 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 1,478 | 1,447 | -31 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 883 | 883 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 99 | 99 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Optiver Holding B.V. | 32 | 32 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Smartleaf Asset Management LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BLUEFIN CAPITAL MANAGEMENT, LLC | 24,018 | 0 | -24,018 | 0.01 | 0.00 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 10,660 | 0 | -10,660 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 900,000 | 0 | -900,000 | 0.02 | 0.00 | -0.02 | sell |
| MARSHALL WACE, LLP | 54,161 | 0 | -54,161 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 18,113 | 0 | -18,113 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 13,116 | 0 | -13,116 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 407 | 0 | -407 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 236,053 | 0 | -236,053 | 0.00 | 0.00 | -0.00 | sell |
| Bain Capital Life Sciences Investors, LLC | 3,538,609 | 0 | -3,538,609 | 0.12 | 0.00 | -0.12 | sell |
| EverSource Wealth Advisors, LLC | 28 | 0 | -28 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 17,501 | 0 | -17,501 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 11,241 | 0 | -11,241 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 2,210 | 0 | -2,210 | 0.00 | 0.00 | -0.00 | sell |