| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 0 | 3,333,334 | +3,333,334 | 0.00 | 1.32 | +1.32 | buy |
| Lynx1 Capital Management LP | 10,763,288 | 13,263,288 | +2,500,000 | 23.92 | 41.19 | +17.27 | buy |
| FMR LLC | 5,136,045 | 5,977,045 | +841,000 | 0.00 | 0.01 | +0.00 | buy |
| Foresite Capital Management VI LLC | 315,492 | 940,493 | +625,001 | 0.96 | 3.93 | +2.97 | buy |
| BRAIDWELL LP | 0 | 207,240 | +207,240 | 0.00 | 0.21 | +0.21 | buy |
| JANE STREET GROUP, LLC | 0 | 169,951 | +169,951 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 44,795 | 148,673 | +103,878 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 69,808 | 153,767 | +83,959 | 0.01 | 0.03 | +0.02 | buy |
| HRT FINANCIAL LP | 0 | 65,375 | +65,375 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 412,416 | 477,408 | +64,992 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 50,882 | +50,882 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 43,948 | +43,948 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 52,090 | 86,986 | +34,896 | 0.01 | 0.03 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 0 | 25,345 | +25,345 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 455,618 | 480,287 | +24,669 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 21,117 | +21,117 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 65,464 | 85,952 | +20,488 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 18,430 | +18,430 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 18,560 | 34,278 | +15,718 | 0.00 | 0.00 | +0.00 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 0 | 15,425 | +15,425 | 0.00 | 0.01 | +0.01 | buy |
| Eversept Partners, LP | 0 | 8,672 | +8,672 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 0 | 7,847 | +7,847 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 6,394 | +6,394 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 5,877 | +5,877 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 83 | 4,739 | +4,656 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 67,034 | 71,267 | +4,233 | 0.17 | 0.23 | +0.06 | buy |
| BARCLAYS PLC | 4,394 | 5,977 | +1,583 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 800 | +800 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 775 | +775 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 20 | 411 | +391 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,310 | 1,697 | +387 | 0.00 | 0.00 | +0.00 | buy |
| HOLLENCREST CAPITAL MANAGEMENT | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 205 | +205 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 11,049 | 11,163 | +114 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 19 | +19 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 8,650,158 | 8,650,158 | 0 | 3.87 | 5.95 | +2.07 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 40,483 | 40,483 | 0 | 0.00 | 0.00 | +0.00 | hold |
| North Star Investment Management Corp. | 2,200 | 2,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ancora Advisors LLC | 284 | 284 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 5,933,815 | 5,933,815 | 0 | 0.83 | 1.36 | +0.53 | hold |
| Avoro Capital Advisors LLC | 1,800,000 | 1,800,000 | 0 | 0.25 | 0.43 | +0.19 | hold |
| Lion Point Capital, LP | 10,200 | 10,200 | 0 | 0.86 | 1.31 | +0.45 | hold |
| Farther Finance Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 712,300 | 712,300 | 0 | 0.12 | 0.18 | +0.05 | hold |
| GF FUND MANAGEMENT CO. LTD. | 1,384 | 1,315 | -69 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 18,853 | 18,778 | -75 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,507 | 13,419 | -88 | 0.01 | 0.02 | +0.01 | sell |
| CITIGROUP INC | 1,733 | 1,614 | -119 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 665 | 515 | -150 | 0.00 | 0.00 | +0.00 | sell |
| OSAIC HOLDINGS, INC. | 5,925 | 5,775 | -150 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 3,235 | 3,068 | -167 | 0.00 | 0.00 | +0.00 | sell |
| Global Retirement Partners, LLC | 400 | 0 | -400 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 32,685 | 31,844 | -841 | 0.00 | 0.00 | +0.00 | sell |
| Arkos Global Advisors | 1,180 | 0 | -1,180 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 15,600 | 12,700 | -2,900 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 20,920 | 15,492 | -5,428 | 0.08 | 0.10 | +0.02 | sell |
| Persistent Asset Partners Ltd | 6,794 | 0 | -6,794 | 0.04 | 0.00 | -0.04 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 20,614 | 0 | -20,614 | 0.00 | 0.00 | -0.00 | sell |
| DIADEMA PARTNERS LP | 26,836 | 0 | -26,836 | 0.16 | 0.00 | -0.16 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 7,676,697 | 7,636,813 | -39,884 | 1.14 | 1.78 | +0.64 | sell |
| MARSHALL WACE, LLP | 91,108 | 46,697 | -44,411 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 213,212 | 158,770 | -54,442 | 0.83 | 0.97 | +0.15 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 282,891 | 202,103 | -80,788 | 0.09 | 0.10 | +0.01 | sell |
| CenterBook Partners LP | 216,574 | 69,436 | -147,138 | 0.16 | 0.09 | -0.07 | sell |
| 5AM Venture Management, LLC | 572,665 | 0 | -572,665 | 2.24 | 0.00 | -2.24 | sell |
| MILLENNIUM MANAGEMENT LLC | 937,898 | 323,399 | -614,499 | 0.01 | 0.01 | -0.00 | sell |
| Troluce Capital Advisors LLC | 990,472 | 0 | -990,472 | 1.47 | 0.00 | -1.47 | sell |
| TORONTO DOMINION BANK | 1,397,873 | 0 | -1,397,873 | 0.04 | 0.00 | -0.04 | sell |