| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 1,838,617 | 3,310,563 | +1,471,946 | 4.19 | 9.09 | +4.90 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 5,587,333 | 6,251,714 | +664,381 | 0.51 | 0.85 | +0.34 | buy |
| 5AM Venture Management, LLC | 404,404 | 572,665 | +168,261 | 0.62 | 1.37 | +0.74 | buy |
| Walleye Capital LLC | 0 | 87,938 | +87,938 | 0.00 | 0.01 | +0.01 | buy |
| Corton Capital Inc. | 0 | 15,526 | +15,526 | 0.00 | 0.06 | +0.06 | buy |
| ADAR1 Capital Management, LLC | 0 | 12,583 | +12,583 | 0.00 | 0.04 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 10,542 | +10,542 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 62,098 | 68,775 | +6,677 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 10,400,158 | 10,400,158 | 0 | 1.51 | 3.05 | +1.54 | hold |
| Laurion Capital Management LP | 64,930 | 64,930 | 0 | 0.01 | 0.02 | +0.01 | hold |
| RTW INVESTMENTS, LP | 3,327,129 | 3,327,129 | 0 | 0.30 | 0.52 | +0.22 | hold |
| Cormorant Asset Management, LP | 593,043 | 593,043 | 0 | 0.16 | 0.28 | +0.11 | hold |
| Qube Research & Technologies Ltd | 109 | 109 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global Retirement Partners, LLC | 220 | 220 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 31,500 | 31,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 99 | 0 | -99 | 0.00 | 0.00 | 0.00 | sell |
| Tortoise Investment Management, LLC | 3,081 | 1,781 | -1,300 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 10,138 | 0 | -10,138 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 10,704 | 0 | -10,704 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 14,481 | 0 | -14,481 | 0.00 | 0.00 | -0.00 | sell |
| AdvisorShares Investments LLC | 48,300 | 30,063 | -18,237 | 0.07 | 0.05 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 50,900 | 30,400 | -20,500 | 0.00 | 0.00 | +0.00 | sell |
| Verition Fund Management LLC | 1,162,485 | 1,129,304 | -33,181 | 0.07 | 0.11 | +0.05 | sell |
| MILLENNIUM MANAGEMENT LLC | 92,115 | 51,807 | -40,308 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 322,230 | 281,314 | -40,916 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 41,279 | 0 | -41,279 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 97,234 | 12,208 | -85,026 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 106,363 | 0 | -106,363 | 0.00 | 0.00 | -0.00 | sell |
| Checkpoint Capital L.P. | 293,945 | 185,653 | -108,292 | 1.19 | 1.32 | +0.13 | sell |
| FMR LLC | 3,136,869 | 3,015,069 | -121,800 | 0.00 | 0.00 | +0.00 | sell |
| Deep Track Capital, LP | 499,400 | 0 | -499,400 | 0.10 | 0.00 | -0.10 | sell |
| VR Adviser, LLC | 1,318,327 | 0 | -1,318,327 | 0.52 | 0.00 | -0.52 | sell |