| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 3,327,129 | 5,499,769 | +2,172,640 | 0.35 | 0.93 | +0.58 | buy |
| Deep Track Capital, LP | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.71 | +0.71 | buy |
| TORONTO DOMINION BANK | 0 | 1,967,293 | +1,967,293 | 0.00 | 0.06 | +0.06 | buy |
| FMR LLC | 2,487,370 | 4,249,580 | +1,762,210 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 4,858,994 | 6,443,940 | +1,584,946 | 12.75 | 25.45 | +12.70 | buy |
| Cormorant Asset Management, LP | 593,043 | 2,009,482 | +1,416,439 | 0.23 | 1.68 | +1.45 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 925,000 | +925,000 | 0.00 | 0.20 | +0.20 | buy |
| Jefferies Financial Group Inc. | 0 | 750,000 | +750,000 | 0.00 | 0.14 | +0.14 | buy |
| Alyeska Investment Group, L.P. | 0 | 454,975 | +454,975 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 0 | 447,934 | +447,934 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 6,686,689 | 6,944,648 | +257,959 | 0.62 | 1.28 | +0.66 | buy |
| Troluce Capital Advisors LLC | 0 | 155,597 | +155,597 | 0.00 | 1.62 | +1.62 | buy |
| Walleye Capital LLC | 0 | 52,940 | +52,940 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 31,625 | +31,625 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 29,914 | +29,914 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 15,586 | +15,586 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 15,354 | +15,354 | 0.00 | 0.01 | +0.01 | buy |
| Palumbo Wealth Management LLC | 0 | 12,869 | +12,869 | 0.00 | 0.05 | +0.05 | buy |
| MORGAN STANLEY | 265,468 | 277,251 | +11,783 | 0.00 | 0.00 | +0.00 | buy |
| PEAK6 LLC | 59,200 | 64,213 | +5,013 | 0.02 | 0.03 | +0.01 | buy |
| GROUP ONE TRADING LLC | 0 | 171 | +171 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,310 | 6,410 | +100 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 17 | +17 | 0.00 | 0.00 | 0.00 | buy |
| Tortoise Investment Management, LLC | 1,781 | 1,781 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 5AM Venture Management, LLC | 572,665 | 572,665 | 0 | 0.96 | 2.39 | +1.43 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 5,050 | 3,775 | -1,275 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 40,834 | 39,331 | -1,503 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 1,703 | 0 | -1,703 | 0.00 | 0.00 | -0.00 | sell |
| AdvisorShares Investments LLC | 36,011 | 33,256 | -2,755 | 0.05 | 0.07 | +0.02 | sell |
| BlackRock, Inc. | 47,214 | 43,971 | -3,243 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 72,513 | 67,215 | -5,298 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 16,761 | 0 | -16,761 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 20,761 | 0 | -20,761 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 30,300 | 0 | -30,300 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 48,352 | 0 | -48,352 | 0.02 | 0.00 | -0.02 | sell |
| Woodline Partners LP | 78,949 | 0 | -78,949 | 0.00 | 0.00 | -0.00 | sell |
| DIADEMA PARTNERS LP | 101,502 | 0 | -101,502 | 0.80 | 0.00 | -0.80 | sell |
| Verition Fund Management LLC | 917,799 | 670,605 | -247,194 | 0.03 | 0.04 | +0.01 | sell |
| BVF INC/IL | 10,400,158 | 8,827,712 | -1,572,446 | 2.47 | 3.97 | +1.50 | sell |