| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TORONTO DOMINION BANK | 0 | 1,397,873 | +1,397,873 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 295,926 | 937,898 | +641,972 | 0.00 | 0.01 | +0.01 | buy |
| Troluce Capital Advisors LLC | 373,212 | 990,472 | +617,260 | 3.50 | 1.47 | -2.03 | buy |
| Lynx1 Capital Management LP | 10,406,575 | 10,763,288 | +356,713 | 26.75 | 23.92 | -2.84 | buy |
| Foresite Capital Management VI LLC | 0 | 315,492 | +315,492 | 0.00 | 0.96 | +0.96 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 112,184 | 282,891 | +170,707 | 0.04 | 0.09 | +0.06 | buy |
| UBS Group AG | 363,381 | 412,416 | +49,035 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 26,258 | 65,464 | +39,206 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 26,836 | +26,836 | 0.00 | 0.16 | +0.16 | buy |
| BlackRock, Inc. | 434,401 | 455,618 | +21,217 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 20,614 | +20,614 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 18,560 | +18,560 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 54,776 | 69,808 | +15,032 | 0.01 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 44,446 | 52,090 | +7,644 | 0.01 | 0.01 | -0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 6,794 | +6,794 | 0.00 | 0.04 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 35,645 | 40,483 | +4,838 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,107 | 13,507 | +3,400 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 2,118 | 4,394 | +2,276 | 0.00 | 0.00 | +0.00 | buy |
| North Star Investment Management Corp. | 0 | 2,200 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| Arkos Global Advisors | 0 | 1,180 | +1,180 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 20,408 | 20,920 | +512 | 0.07 | 0.08 | +0.01 | buy |
| Ancora Advisors LLC | 0 | 284 | +284 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 10,821 | 11,049 | +228 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,014 | 3,235 | +221 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,218 | 1,384 | +166 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 48 | 83 | +35 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 7,676,697 | 7,676,697 | 0 | 1.00 | 1.14 | +0.14 | hold |
| HighTower Advisors, LLC | 15,600 | 15,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 5,933,815 | 5,933,815 | 0 | 0.75 | 0.83 | +0.08 | hold |
| Avoro Capital Advisors LLC | 1,800,000 | 1,800,000 | 0 | 0.22 | 0.25 | +0.02 | hold |
| Lion Point Capital, LP | 10,200 | 10,200 | 0 | 0.67 | 0.86 | +0.19 | hold |
| 5AM Venture Management, LLC | 572,665 | 572,665 | 0 | 2.29 | 2.24 | -0.05 | hold |
| SBI Securities Co., Ltd. | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 5,136,045 | 5,136,045 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 712,300 | 712,300 | 0 | 0.07 | 0.12 | +0.05 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 1,337 | 1,310 | -27 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 18,881 | 18,853 | -28 | 0.00 | 0.00 | +0.00 | sell |
| AdvisorShares Investments LLC | 67,112 | 67,034 | -78 | 0.14 | 0.17 | +0.03 | sell |
| Tower Research Capital LLC (TRC) | 770 | 665 | -105 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 32,828 | 32,685 | -143 | 0.00 | 0.00 | +0.00 | sell |
| Daiwa Securities Group Inc. | 207 | 0 | -207 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 4,404 | 1,733 | -2,671 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 10,025 | 5,925 | -4,100 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 15,936 | 0 | -15,936 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 18,565 | 0 | -18,565 | 0.02 | 0.00 | -0.02 | sell |
| HighVista Strategies LLC | 240,524 | 213,212 | -27,312 | 0.79 | 0.83 | +0.04 | sell |
| GOLDMAN SACHS GROUP INC | 80,986 | 44,795 | -36,191 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 50,000 | 0 | -50,000 | 0.03 | 0.00 | -0.03 | sell |
| JANE STREET GROUP, LLC | 50,005 | 0 | -50,005 | 0.00 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 283,441 | 216,574 | -66,867 | 0.18 | 0.16 | -0.01 | sell |
| MARSHALL WACE, LLP | 240,764 | 91,108 | -149,656 | 0.00 | 0.00 | -0.00 | sell |
| BVF INC/IL | 8,827,712 | 8,650,158 | -177,554 | 3.77 | 3.87 | +0.10 | sell |
| Alyeska Investment Group, L.P. | 204,975 | 0 | -204,975 | 0.01 | 0.00 | -0.01 | sell |
| Verition Fund Management LLC | 673,735 | 0 | -673,735 | 0.05 | 0.00 | -0.05 | sell |
| Cormorant Asset Management, LP | 1,300,000 | 0 | -1,300,000 | 0.94 | 0.00 | -0.94 | sell |