| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 3,310,563 | 3,966,726 | +656,163 | 9.09 | 16.72 | +7.63 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 6,251,714 | 6,601,689 | +349,975 | 0.85 | 1.02 | +0.17 | buy |
| CITADEL ADVISORS LLC | 12,208 | 157,492 | +145,284 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 40,573 | +40,573 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 1,129,304 | 1,140,632 | +11,328 | 0.11 | 0.10 | -0.01 | buy |
| MORGAN STANLEY | 281,314 | 291,945 | +10,631 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 1,127 | +1,127 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 68,775 | 69,611 | +836 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 30,400 | 30,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 10,400,158 | 10,400,158 | 0 | 3.05 | 3.40 | +0.35 | hold |
| Laurion Capital Management LP | 64,930 | 64,930 | 0 | 0.02 | 0.02 | +0.01 | hold |
| RTW INVESTMENTS, LP | 3,327,129 | 3,327,129 | 0 | 0.52 | 0.60 | +0.08 | hold |
| Cormorant Asset Management, LP | 593,043 | 593,043 | 0 | 0.28 | 0.40 | +0.12 | hold |
| Tortoise Investment Management, LLC | 1,781 | 1,781 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global Retirement Partners, LLC | 220 | 220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 572,665 | 572,665 | 0 | 1.37 | 1.49 | +0.13 | hold |
| Farther Finance Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qube Research & Technologies Ltd | 109 | 0 | -109 | 0.00 | 0.00 | -0.00 | sell |
| AdvisorShares Investments LLC | 30,063 | 22,605 | -7,458 | 0.05 | 0.05 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,542 | 0 | -10,542 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 12,583 | 1,850 | -10,733 | 0.04 | 0.00 | -0.03 | sell |
| BARCLAYS PLC | 31,500 | 19,909 | -11,591 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 15,526 | 0 | -15,526 | 0.06 | 0.00 | -0.06 | sell |
| FMR LLC | 3,015,069 | 2,966,374 | -48,695 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 51,807 | 0 | -51,807 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 87,938 | 23,896 | -64,042 | 0.01 | 0.00 | -0.01 | sell |
| Checkpoint Capital L.P. | 185,653 | 0 | -185,653 | 1.32 | 0.00 | -1.32 | sell |