| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,249,580 | 5,092,145 | +842,565 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 6,944,648 | 7,676,697 | +732,049 | 1.28 | 1.58 | +0.30 | buy |
| Lynx1 Capital Management LP | 6,443,940 | 6,746,951 | +303,011 | 25.45 | 23.76 | -1.70 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 203,645 | +203,645 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 100,826 | +100,826 | 0.00 | 0.40 | +0.40 | buy |
| HighVista Strategies LLC | 0 | 52,247 | +52,247 | 0.00 | 0.23 | +0.23 | buy |
| RTW INVESTMENTS, LP | 5,499,769 | 5,540,457 | +40,688 | 0.93 | 0.96 | +0.03 | buy |
| HighTower Advisors, LLC | 0 | 22,300 | +22,300 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 43,971 | 64,745 | +20,774 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 447,934 | 458,582 | +10,648 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,410 | 17,010 | +10,600 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 12,869 | 21,651 | +8,782 | 0.05 | 0.08 | +0.03 | buy |
| Virtus Investment Advisers, LLC | 0 | 7,329 | +7,329 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 0 | 6,500 | +6,500 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 33,256 | 38,256 | +5,000 | 0.07 | 0.08 | +0.01 | buy |
| MORGAN STANLEY | 277,251 | 281,002 | +3,751 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 3,775 | 6,175 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 17 | 25 | +8 | 0.00 | 0.00 | 0.00 | buy |
| BVF INC/IL | 8,827,712 | 8,827,712 | 0 | 3.97 | 3.84 | -0.12 | hold |
| Cormorant Asset Management, LP | 2,009,482 | 2,009,482 | 0 | 1.68 | 1.82 | +0.15 | hold |
| 5AM Venture Management, LLC | 572,665 | 572,665 | 0 | 2.39 | 2.68 | +0.29 | hold |
| Deep Track Capital, LP | 2,000,000 | 2,000,000 | 0 | 0.71 | 0.78 | +0.07 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TORONTO DOMINION BANK | 1,967,293 | 1,967,293 | 0 | 0.06 | 0.05 | -0.00 | hold |
| GROUP ONE TRADING LLC | 171 | 80 | -91 | 0.00 | 0.00 | -0.00 | sell |
| Global Retirement Partners, LLC | 220 | 110 | -110 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 39,331 | 38,977 | -354 | 0.00 | 0.00 | +0.00 | sell |
| Tortoise Investment Management, LLC | 1,781 | 0 | -1,781 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 31,625 | 20,108 | -11,517 | 0.01 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 670,605 | 657,381 | -13,224 | 0.04 | 0.05 | +0.00 | sell |
| XTX Topco Ltd | 15,354 | 0 | -15,354 | 0.01 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 15,586 | 0 | -15,586 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 29,914 | 13,833 | -16,081 | 0.01 | 0.01 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 67,215 | 34,633 | -32,582 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 750,000 | 709,312 | -40,688 | 0.14 | 0.14 | +0.00 | sell |
| PEAK6 LLC | 64,213 | 20,000 | -44,213 | 0.03 | 0.01 | -0.02 | sell |
| Walleye Capital LLC | 52,940 | 0 | -52,940 | 0.01 | 0.00 | -0.01 | sell |
| Troluce Capital Advisors LLC | 155,597 | 85,791 | -69,806 | 1.62 | 0.53 | -1.09 | sell |
| Alyeska Investment Group, L.P. | 454,975 | 254,975 | -200,000 | 0.02 | 0.01 | -0.01 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 925,000 | 0 | -925,000 | 0.20 | 0.00 | -0.20 | sell |