| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 3,966,726 | 4,195,894 | +229,168 | 16.72 | 9.95 | -6.77 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 6,601,689 | 6,686,689 | +85,000 | 1.02 | 0.52 | -0.50 | buy |
| CITADEL ADVISORS LLC | 157,492 | 215,717 | +58,225 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 0 | 37,238 | +37,238 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 32,193 | +32,193 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 22,605 | 31,205 | +8,600 | 0.05 | 0.04 | -0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 30,400 | 30,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 10,400,158 | 10,400,158 | 0 | 3.40 | 2.04 | -1.36 | hold |
| RTW INVESTMENTS, LP | 3,327,129 | 3,327,129 | 0 | 0.60 | 0.32 | -0.28 | hold |
| Cormorant Asset Management, LP | 593,043 | 593,043 | 0 | 0.40 | 0.21 | -0.19 | hold |
| Tortoise Investment Management, LLC | 1,781 | 1,781 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Retirement Partners, LLC | 220 | 220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 572,665 | 572,665 | 0 | 1.49 | 0.79 | -0.70 | hold |
| Farther Finance Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 69,611 | 69,421 | -190 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 1,127 | 0 | -1,127 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 1,850 | 0 | -1,850 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 40,573 | 38,362 | -2,211 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 19,909 | 5,984 | -13,925 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 64,930 | 48,352 | -16,578 | 0.02 | 0.02 | -0.00 | sell |
| Walleye Capital LLC | 23,896 | 0 | -23,896 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 291,945 | 258,620 | -33,325 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 1,140,632 | 1,057,782 | -82,850 | 0.10 | 0.05 | -0.05 | sell |
| FMR LLC | 2,966,374 | 2,745,445 | -220,929 | 0.00 | 0.00 | -0.00 | sell |