| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 6,746,951 | 8,601,189 | +1,854,238 | 23.76 | 21.23 | -2.53 | buy |
| MILLENNIUM MANAGEMENT LLC | 203,645 | 863,602 | +659,957 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 100,826 | 545,275 | +444,449 | 0.40 | 1.57 | +1.18 | buy |
| FMR LLC | 5,092,145 | 5,327,045 | +234,900 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 52,247 | 241,894 | +189,647 | 0.23 | 0.85 | +0.61 | buy |
| MARSHALL WACE, LLP | 0 | 169,500 | +169,500 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 0 | 166,153 | +166,153 | 0.00 | 0.12 | +0.12 | buy |
| CITADEL ADVISORS LLC | 0 | 94,402 | +94,402 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 76,958 | +76,958 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 13,833 | 83,550 | +69,717 | 0.01 | 0.03 | +0.02 | buy |
| UBS Group AG | 458,582 | 511,464 | +52,882 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 36,103 | +36,103 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 5,540,457 | 5,569,564 | +29,107 | 0.96 | 0.98 | +0.02 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 24,030 | +24,030 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 23,004 | +23,004 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 22,732 | +22,732 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 22,060 | +22,060 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 657,381 | 678,489 | +21,108 | 0.05 | 0.06 | +0.01 | buy |
| AdvisorShares Investments LLC | 38,256 | 53,991 | +15,735 | 0.08 | 0.13 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 11,075 | +11,075 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 10,992 | +10,992 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 6,500 | 13,900 | +7,400 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 25 | 4,209 | +4,184 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 6,175 | 10,125 | +3,950 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 7,329 | 8,869 | +1,540 | 0.03 | 0.04 | +0.01 | buy |
| BARCLAYS PLC | 0 | 1,296 | +1,296 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 34,633 | 35,645 | +1,012 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 110 | 800 | +690 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 31 | +31 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 80 | 100 | +20 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 8,827,712 | 8,827,712 | 0 | 3.84 | 5.12 | +1.27 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 7,676,697 | 7,676,697 | 0 | 1.58 | 1.35 | -0.22 | hold |
| 5AM Venture Management, LLC | 572,665 | 572,665 | 0 | 2.68 | 3.00 | +0.32 | hold |
| Jefferies Financial Group Inc. | 709,312 | 709,312 | 0 | 0.14 | 0.09 | -0.05 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 2,000 | 0 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 38,977 | 32,973 | -6,004 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 22,300 | 16,100 | -6,200 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 64,745 | 57,859 | -6,886 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 17,010 | 6,202 | -10,808 | 0.00 | 0.00 | -0.00 | sell |
| PEAK6 LLC | 20,000 | 0 | -20,000 | 0.01 | 0.00 | -0.01 | sell |
| Quadrature Capital Ltd | 20,108 | 0 | -20,108 | 0.00 | 0.00 | -0.00 | sell |
| Palumbo Wealth Management LLC | 21,651 | 0 | -21,651 | 0.08 | 0.00 | -0.08 | sell |
| Troluce Capital Advisors LLC | 85,791 | 46,722 | -39,069 | 0.53 | 0.24 | -0.30 | sell |
| Alyeska Investment Group, L.P. | 254,975 | 204,975 | -50,000 | 0.01 | 0.01 | -0.00 | sell |
| Cormorant Asset Management, LP | 2,009,482 | 1,916,439 | -93,043 | 1.82 | 1.89 | +0.07 | sell |
| MORGAN STANLEY | 281,002 | 0 | -281,002 | 0.00 | 0.00 | -0.00 | sell |
| Deep Track Capital, LP | 2,000,000 | 1,250,000 | -750,000 | 0.78 | 0.50 | -0.28 | sell |
| TORONTO DOMINION BANK | 1,967,293 | 0 | -1,967,293 | 0.05 | 0.00 | -0.05 | sell |