| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 9,275,158 | 10,400,158 | +1,125,000 | 2.51 | 1.51 | -1.00 | buy |
| Lynx1 Capital Management LP | 1,103,178 | 1,838,617 | +735,439 | 7.33 | 4.19 | -3.14 | buy |
| Squarepoint Ops LLC | 0 | 41,279 | +41,279 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 307,209 | 322,230 | +15,021 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 14,481 | +14,481 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 92,784 | 106,363 | +13,579 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 0 | 10,138 | +10,138 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 44,400 | 50,900 | +6,500 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 57,184 | 62,098 | +4,914 | 0.00 | 0.00 | -0.00 | buy |
| AdvisorShares Investments LLC | 46,323 | 48,300 | +1,977 | 0.12 | 0.07 | -0.06 | buy |
| SIMPLEX TRADING, LLC | 0 | 99 | +99 | 0.00 | 0.00 | 0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 5,587,333 | 5,587,333 | 0 | 1.11 | 0.51 | -0.60 | hold |
| Laurion Capital Management LP | 64,930 | 64,930 | 0 | 0.02 | 0.01 | -0.00 | hold |
| RTW INVESTMENTS, LP | 3,327,129 | 3,327,129 | 0 | 0.71 | 0.30 | -0.40 | hold |
| Cormorant Asset Management, LP | 593,043 | 593,043 | 0 | 0.35 | 0.16 | -0.18 | hold |
| Tortoise Investment Management, LLC | 3,081 | 3,081 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qube Research & Technologies Ltd | 109 | 109 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Retirement Partners, LLC | 220 | 220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 404,404 | 404,404 | 0 | 1.17 | 0.62 | -0.55 | hold |
| Deep Track Capital, LP | 499,400 | 499,400 | 0 | 0.19 | 0.10 | -0.09 | hold |
| Farther Finance Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 10,704 | 10,704 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 107,291 | 92,115 | -15,176 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 1,185,238 | 1,162,485 | -22,753 | 0.16 | 0.07 | -0.09 | sell |
| BARCLAYS PLC | 63,590 | 31,500 | -32,090 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 167,921 | 97,234 | -70,687 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 3,235,469 | 3,136,869 | -98,600 | 0.00 | 0.00 | -0.00 | sell |
| VR Adviser, LLC | 2,744,125 | 1,318,327 | -1,425,798 | 2.90 | 0.52 | -2.38 | sell |