| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 4,195,894 | 4,858,994 | +663,100 | 9.95 | 12.75 | +2.81 | buy |
| Woodline Partners LP | 37,238 | 78,949 | +41,711 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 20,761 | +20,761 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 16,761 | +16,761 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 32,193 | 40,834 | +8,641 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 258,620 | 265,468 | +6,848 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 6,310 | +6,310 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 5,050 | +5,050 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 31,205 | 36,011 | +4,806 | 0.04 | 0.05 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 69,421 | 72,513 | +3,092 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 10,400,158 | 10,400,158 | 0 | 2.04 | 2.47 | +0.43 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,686,689 | 6,686,689 | 0 | 0.52 | 0.62 | +0.11 | hold |
| Laurion Capital Management LP | 48,352 | 48,352 | 0 | 0.02 | 0.02 | +0.00 | hold |
| RTW INVESTMENTS, LP | 3,327,129 | 3,327,129 | 0 | 0.32 | 0.35 | +0.03 | hold |
| Cormorant Asset Management, LP | 593,043 | 593,043 | 0 | 0.21 | 0.23 | +0.02 | hold |
| Tortoise Investment Management, LLC | 1,781 | 1,781 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global Retirement Partners, LLC | 220 | 220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 572,665 | 572,665 | 0 | 0.79 | 0.96 | +0.17 | hold |
| Farther Finance Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 30,400 | 30,300 | -100 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 5,984 | 1,703 | -4,281 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 64,892 | 47,214 | -17,678 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 38,362 | 0 | -38,362 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 1,057,782 | 917,799 | -139,983 | 0.05 | 0.03 | -0.02 | sell |
| CITADEL ADVISORS LLC | 215,717 | 0 | -215,717 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 2,745,445 | 2,487,370 | -258,075 | 0.00 | 0.00 | -0.00 | sell |