| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 8,601,189 | 10,406,575 | +1,805,386 | 21.23 | 26.75 | +5.52 | buy |
| Avoro Capital Advisors LLC | 0 | 1,800,000 | +1,800,000 | 0.00 | 0.22 | +0.22 | buy |
| BlackRock, Inc. | 57,859 | 434,401 | +376,542 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 5,569,564 | 5,933,815 | +364,251 | 0.98 | 0.75 | -0.23 | buy |
| Troluce Capital Advisors LLC | 46,722 | 373,212 | +326,490 | 0.24 | 3.50 | +3.26 | buy |
| CenterBook Partners LP | 166,153 | 283,441 | +117,288 | 0.12 | 0.18 | +0.06 | buy |
| MARSHALL WACE, LLP | 169,500 | 240,764 | +71,264 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 11,075 | 80,986 | +69,911 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 54,776 | +54,776 | 0.00 | 0.01 | +0.01 | buy |
| BIT Capital GmbH | 0 | 50,000 | +50,000 | 0.00 | 0.03 | +0.03 | buy |
| XTX Topco Ltd | 0 | 44,446 | +44,446 | 0.00 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 83,550 | 112,184 | +28,634 | 0.03 | 0.04 | +0.01 | buy |
| JANE STREET GROUP, LLC | 23,004 | 50,005 | +27,001 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 18,565 | +18,565 | 0.00 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 0 | 15,936 | +15,936 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 53,991 | 67,112 | +13,121 | 0.13 | 0.14 | +0.02 | buy |
| Virtus Investment Advisers, LLC | 8,869 | 20,408 | +11,539 | 0.04 | 0.07 | +0.03 | buy |
| Lion Point Capital, LP | 0 | 10,200 | +10,200 | 0.00 | 0.67 | +0.67 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 10,107 | +10,107 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 13,900 | 18,881 | +4,981 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 31 | 4,404 | +4,373 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 3,014 | +3,014 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 709,312 | 712,300 | +2,988 | 0.09 | 0.07 | -0.02 | buy |
| GF FUND MANAGEMENT CO. LTD. | 0 | 1,218 | +1,218 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,296 | 2,118 | +822 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 770 | +770 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 207 | +207 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 8,827,712 | 8,827,712 | 0 | 5.12 | 3.77 | -1.34 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 35,645 | 35,645 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 7,676,697 | 7,676,697 | 0 | 1.35 | 1.00 | -0.35 | hold |
| Alyeska Investment Group, L.P. | 204,975 | 204,975 | 0 | 0.01 | 0.01 | -0.00 | hold |
| 5AM Venture Management, LLC | 572,665 | 572,665 | 0 | 3.00 | 2.29 | -0.71 | hold |
| OSAIC HOLDINGS, INC. | 10,125 | 10,025 | -100 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 32,973 | 32,828 | -145 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 10,992 | 10,821 | -171 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 200 | 0 | -200 | 0.00 | 0.00 | -0.00 | sell |
| Global Retirement Partners, LLC | 800 | 400 | -400 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 16,100 | 15,600 | -500 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 241,894 | 240,524 | -1,370 | 0.85 | 0.79 | -0.06 | sell |
| SIMPLEX TRADING, LLC | 4,209 | 48 | -4,161 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 678,489 | 673,735 | -4,754 | 0.06 | 0.05 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 6,202 | 1,337 | -4,865 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 22,060 | 0 | -22,060 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 24,030 | 0 | -24,030 | 0.01 | 0.00 | -0.01 | sell |
| Squarepoint Ops LLC | 36,103 | 0 | -36,103 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 94,402 | 26,258 | -68,144 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 76,958 | 0 | -76,958 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 511,464 | 363,381 | -148,083 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 5,327,045 | 5,136,045 | -191,000 | 0.00 | 0.00 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 545,275 | 0 | -545,275 | 1.57 | 0.00 | -1.57 | sell |
| MILLENNIUM MANAGEMENT LLC | 863,602 | 295,926 | -567,676 | 0.01 | 0.00 | -0.01 | sell |
| Cormorant Asset Management, LP | 1,916,439 | 1,300,000 | -616,439 | 1.89 | 0.94 | -0.96 | sell |
| Deep Track Capital, LP | 1,250,000 | 0 | -1,250,000 | 0.50 | 0.00 | -0.50 | sell |