| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 830,687 | 1,535,449 | +704,762 | 0.01 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 282,874 | 807,874 | +525,000 | 0.42 | 1.51 | +1.09 | buy |
| CITADEL ADVISORS LLC | 0 | 350,200 | +350,200 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 2,448,979 | 2,734,836 | +285,857 | 0.01 | 0.02 | +0.00 | buy |
| Longaeva Partners L.P. | 470,000 | 732,088 | +262,088 | 0.64 | 0.46 | -0.18 | buy |
| GOLDMAN SACHS GROUP INC | 105,594 | 307,108 | +201,514 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 43,078 | 232,534 | +189,456 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 72,494 | 222,329 | +149,835 | 0.02 | 0.07 | +0.05 | buy |
| BlackRock, Inc. | 536,155 | 669,123 | +132,968 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 265,761 | 371,636 | +105,875 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 27,945 | 107,380 | +79,435 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 213,869 | 282,038 | +68,169 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 59,946 | +59,946 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 59,844 | +59,844 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 55,609 | +55,609 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 47,449 | +47,449 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 180,804 | 226,302 | +45,498 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 35,846 | +35,846 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 110,061 | 144,009 | +33,948 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 199,389 | 230,409 | +31,020 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 22,984 | +22,984 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 19,426 | 42,178 | +22,752 | 0.00 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 22,170 | +22,170 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 20,600 | +20,600 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 25,938 | 42,818 | +16,880 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 84,428 | 101,278 | +16,850 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 19,522 | 35,681 | +16,159 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 16,000 | +16,000 | 0.00 | 0.04 | +0.04 | buy |
| Engineers Gate Manager LP | 0 | 14,956 | +14,956 | 0.00 | 0.00 | +0.00 | buy |
| Cannon Global Investment Management, LLC | 0 | 13,000 | +13,000 | 0.00 | 0.41 | +0.41 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 57,100 | 69,400 | +12,300 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 53,876 | 65,928 | +12,052 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 10,729 | +10,729 | 0.00 | 0.04 | +0.04 | buy |
| China Universal Asset Management Co., Ltd. | 3,764 | 13,503 | +9,739 | 0.00 | 0.01 | +0.01 | buy |
| Eversept Partners, LP | 137,493 | 146,411 | +8,918 | 0.09 | 0.13 | +0.04 | buy |
| ROYAL BANK OF CANADA | 0 | 5,794 | +5,794 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 124 | 731 | +607 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,122 | 1,588 | +466 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 800,000 | 800,198 | +198 | 2.96 | 2.56 | -0.41 | buy |
| US BANCORP \DE\ | 0 | 123 | +123 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 454 | 513 | +59 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 49,280 | 49,280 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RBF Capital, LLC | 20,000 | 20,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 37,916 | 37,916 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,420,838 | 1,420,838 | 0 | 0.10 | 0.11 | +0.01 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 173,475 | 173,475 | 0 | 0.41 | 0.39 | -0.02 | hold |
| Casdin Capital, LLC | 148,333 | 148,333 | 0 | 0.11 | 0.15 | +0.04 | hold |
| Versant Venture Management, LLC | 542,628 | 542,628 | 0 | 4.11 | 5.01 | +0.91 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,841,334 | 2,841,334 | 0 | 0.81 | 1.01 | +0.20 | hold |
| HHLR ADVISORS, LTD. | 669,337 | 669,337 | 0 | 0.25 | 0.52 | +0.28 | hold |
| Strategies Wealth Advisors, LLC | 50,000 | 50,000 | 0 | 0.06 | 0.07 | +0.01 | hold |
| JOHNSON & JOHNSON | 1,979,173 | 1,979,173 | 0 | 4.08 | 3.96 | -0.11 | hold |
| Boxer Capital Management, LLC | 494,000 | 494,000 | 0 | 1.24 | 0.85 | -0.39 | hold |
| Red Tree Management, LLC | 638,158 | 638,158 | 0 | 6.69 | 7.45 | +0.76 | hold |
| Banque Transatlantique SA | 220 | 220 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 814,871 | 814,871 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,300 | 11,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 1,180 | 1,145 | -35 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 103 | 0 | -103 | 0.00 | 0.00 | -0.00 | sell |
| Optiver Holding B.V. | 104 | 0 | -104 | 0.00 | 0.00 | -0.00 | sell |
| Fortitude Family Office, LLC | 445 | 0 | -445 | 0.00 | 0.00 | -0.00 | sell |
| Federation des caisses Desjardins du Quebec | 2,560 | 1,280 | -1,280 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 278,961 | 276,661 | -2,300 | 0.24 | 0.22 | -0.02 | sell |
| CITIGROUP INC | 12,324 | 8,860 | -3,464 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 307,540 | 301,729 | -5,811 | 0.51 | 0.46 | -0.04 | sell |
| Quadrature Capital Ltd | 23,377 | 12,799 | -10,578 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 64,705 | 54,068 | -10,637 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 59,031 | 47,746 | -11,285 | 0.01 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 13,853 | 0 | -13,853 | 0.08 | 0.00 | -0.08 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 15,036 | 0 | -15,036 | 0.01 | 0.00 | -0.01 | sell |
| BARCLAYS PLC | 59,507 | 43,958 | -15,549 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 17,074 | 0 | -17,074 | 0.01 | 0.00 | -0.01 | sell |
| OMERS ADMINISTRATION Corp | 34,900 | 14,200 | -20,700 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 22,673 | 0 | -22,673 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 64,228 | 39,879 | -24,349 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 91,442 | 55,000 | -36,442 | 0.09 | 0.07 | -0.02 | sell |
| ExodusPoint Capital Management, LP | 51,028 | 12,382 | -38,646 | 0.01 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 1,879,367 | 1,839,227 | -40,140 | 0.01 | 0.01 | +0.00 | sell |
| Samsara BioCapital, LLC | 72,245 | 0 | -72,245 | 0.09 | 0.00 | -0.09 | sell |
| SECTORAL ASSET MANAGEMENT INC | 800,787 | 727,587 | -73,200 | 7.34 | 7.87 | +0.53 | sell |
| Monashee Investment Management LLC | 137,430 | 0 | -137,430 | 0.89 | 0.00 | -0.89 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,842,800 | 1,685,635 | -157,165 | 0.04 | 0.04 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 1,464,592 | 1,255,592 | -209,000 | 0.31 | 0.32 | +0.02 | sell |
| AMERIPRISE FINANCIAL INC | 209,633 | 0 | -209,633 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 759,227 | 84,891 | -674,336 | 0.01 | 0.00 | -0.01 | sell |
| Commodore Capital LP | 816,326 | 0 | -816,326 | 0.62 | 0.00 | -0.62 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 2,179,711 | 1,296,012 | -883,699 | 0.26 | 0.18 | -0.08 | sell |