| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 669,123 | 2,064,345 | +1,395,222 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 282,038 | 693,188 | +411,150 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 328,000 | +328,000 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 101,278 | 425,902 | +324,624 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 814,871 | 1,040,130 | +225,259 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 214,082 | +214,082 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 65,928 | 277,804 | +211,876 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 307,108 | 497,255 | +190,147 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 800,198 | 921,481 | +121,283 | 2.56 | 3.56 | +1.00 | buy |
| DIADEMA PARTNERS LP | 0 | 119,733 | +119,733 | 0.00 | 0.69 | +0.69 | buy |
| DIMENSIONAL FUND ADVISORS LP | 59,946 | 178,673 | +118,727 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 55,609 | 150,797 | +95,188 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 732,088 | 812,757 | +80,669 | 0.46 | 0.38 | -0.08 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 144,009 | 214,082 | +70,073 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 69,441 | +69,441 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 0 | 65,604 | +65,604 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 63,095 | +63,095 | 0.00 | 0.72 | +0.72 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 60,253 | +60,253 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 350,200 | 396,354 | +46,154 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 47,746 | 88,479 | +40,733 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 39,879 | 78,920 | +39,041 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 35,707 | +35,707 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 33,210 | +33,210 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 33,037 | +33,037 | 0.00 | 0.17 | +0.17 | buy |
| RHUMBLINE ADVISERS | 0 | 31,098 | +31,098 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 26,216 | +26,216 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 22,510 | +22,510 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,300 | 33,665 | +22,365 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 19,653 | +19,653 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 16,447 | +16,447 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 15,771 | +15,771 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 35,681 | 50,513 | +14,832 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 43,958 | 58,173 | +14,215 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 13,481 | +13,481 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 12,324 | +12,324 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 173,475 | 183,475 | +10,000 | 0.39 | 0.43 | +0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 9,400 | +9,400 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 16,000 | 25,073 | +9,073 | 0.04 | 0.06 | +0.02 | buy |
| NATIXIS | 0 | 9,072 | +9,072 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 7,927 | +7,927 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 8,860 | 13,193 | +4,333 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 2,614 | +2,614 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 2,439 | +2,439 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 276,661 | 278,961 | +2,300 | 0.22 | 0.21 | -0.00 | buy |
| Eversept Partners, LP | 146,411 | 148,017 | +1,606 | 0.13 | 0.13 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 731 | 2,164 | +1,433 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 1,405 | +1,405 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 542 | +542 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 370 | +370 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 5,794 | 5,943 | +149 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 513 | 647 | +134 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 24 | +24 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 1 | 19 | +18 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 49,280 | 49,280 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RBF Capital, LLC | 20,000 | 20,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 1,255,592 | 1,255,592 | 0 | 0.32 | 0.32 | -0.00 | hold |
| SECTORAL ASSET MANAGEMENT INC | 727,587 | 727,587 | 0 | 7.87 | 8.32 | +0.45 | hold |
| Casdin Capital, LLC | 148,333 | 148,333 | 0 | 0.15 | 0.12 | -0.03 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 222,329 | 222,329 | 0 | 0.07 | 0.07 | +0.00 | hold |
| Versant Venture Management, LLC | 542,628 | 542,628 | 0 | 5.01 | 5.47 | +0.46 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,841,334 | 2,841,334 | 0 | 1.01 | 0.98 | -0.03 | hold |
| HHLR ADVISORS, LTD. | 669,337 | 669,337 | 0 | 0.52 | 1.32 | +0.80 | hold |
| Ikarian Capital, LLC | 807,874 | 807,874 | 0 | 1.51 | 2.17 | +0.66 | hold |
| Strategies Wealth Advisors, LLC | 50,000 | 50,000 | 0 | 0.07 | 0.07 | +0.01 | hold |
| JOHNSON & JOHNSON | 1,979,173 | 1,979,173 | 0 | 3.96 | 4.06 | +0.10 | hold |
| Boxer Capital Management, LLC | 494,000 | 494,000 | 0 | 0.85 | 0.61 | -0.24 | hold |
| Federation des caisses Desjardins du Quebec | 1,280 | 1,280 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Red Tree Management, LLC | 638,158 | 638,158 | 0 | 7.45 | 7.10 | -0.35 | hold |
| Banque Transatlantique SA | 220 | 220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 123 | 123 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 1,839,227 | 1,839,227 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 1,588 | 1,464 | -124 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 47,449 | 46,566 | -883 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 69,400 | 67,300 | -2,100 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,503 | 11,208 | -2,295 | 0.01 | 0.01 | -0.00 | sell |
| Engineers Gate Manager LP | 14,956 | 10,961 | -3,995 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 35,846 | 30,356 | -5,490 | 0.01 | 0.01 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 20,600 | 15,100 | -5,500 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 301,729 | 296,135 | -5,594 | 0.46 | 0.54 | +0.08 | sell |
| TWO SIGMA INVESTMENTS, LP | 37,916 | 30,347 | -7,569 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 10,729 | 0 | -10,729 | 0.04 | 0.00 | -0.04 | sell |
| ExodusPoint Capital Management, LP | 12,382 | 0 | -12,382 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 12,799 | 0 | -12,799 | 0.00 | 0.00 | -0.00 | sell |
| Cannon Global Investment Management, LLC | 13,000 | 0 | -13,000 | 0.41 | 0.00 | -0.41 | sell |
| OMERS ADMINISTRATION Corp | 14,200 | 0 | -14,200 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 22,170 | 0 | -22,170 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 22,984 | 0 | -22,984 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 42,178 | 0 | -42,178 | 0.01 | 0.00 | -0.01 | sell |
| Hudson Bay Capital Management LP | 42,818 | 0 | -42,818 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 59,844 | 11,736 | -48,108 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 232,534 | 182,413 | -50,121 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 54,068 | 0 | -54,068 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 55,000 | 0 | -55,000 | 0.07 | 0.00 | -0.07 | sell |
| Point72 Asset Management, L.P. | 84,891 | 25,779 | -59,112 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 230,409 | 130,642 | -99,767 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 107,380 | 0 | -107,380 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 226,302 | 118,058 | -108,244 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,685,635 | 1,522,793 | -162,842 | 0.04 | 0.05 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 371,636 | 75,559 | -296,077 | 0.01 | 0.00 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,535,449 | 931,709 | -603,740 | 0.01 | 0.01 | -0.00 | sell |