| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FRANKLIN RESOURCES INC | 627,008 | 1,447,550 | +820,542 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 323,600 | 696,927 | +373,327 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 150,000 | 350,000 | +200,000 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 19,377 | 62,717 | +43,340 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 91,806 | 113,566 | +21,760 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 11,142 | +11,142 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 11,136 | +11,136 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 0 | 8,967 | +8,967 | 0.00 | 0.03 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 500 | 6,743 | +6,243 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 2,383 | 8,308 | +5,925 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 72,831 | 77,297 | +4,466 | 0.48 | 0.53 | +0.04 | buy |
| CITIGROUP INC | 1,529 | 4,882 | +3,353 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 3,077 | +3,077 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 214,442 | 216,601 | +2,159 | 0.02 | 0.02 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 480 | +480 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 168 | +168 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 680 | 680 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 312,500 | 312,500 | 0 | 0.07 | 0.06 | -0.01 | hold |
| SECTORAL ASSET MANAGEMENT INC | 800,887 | 800,887 | 0 | 5.73 | 9.05 | +3.32 | hold |
| Board of Trustees of The Leland Stanford Junior University | 38,869 | 38,869 | 0 | 0.05 | 0.06 | +0.02 | hold |
| Casdin Capital, LLC | 296,666 | 296,666 | 0 | 0.40 | 0.38 | -0.02 | hold |
| Versant Venture Management, LLC | 918,163 | 918,163 | 0 | 20.92 | 27.64 | +6.73 | hold |
| HHLR ADVISORS, LTD. | 669,337 | 669,337 | 0 | 0.29 | 0.28 | -0.01 | hold |
| JOHNSON & JOHNSON | 1,979,173 | 1,979,173 | 0 | 8.70 | 8.86 | +0.17 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 2,087 | 2,087 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 1,300 | 1,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 240 | 240 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 66,667 | 66,667 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Samsara BioCapital, LLC | 588,817 | 588,816 | -1 | 2.17 | 2.17 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 503 | 420 | -83 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 6,722 | 6,042 | -680 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 3,735 | 3,013 | -722 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 1,926 | 0 | -1,926 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 2,548 | 0 | -2,548 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,400 | 600 | -4,800 | 0.00 | 0.00 | -0.00 | sell |
| Sandia Investment Management LP | 5,000 | 0 | -5,000 | 0.11 | 0.00 | -0.11 | sell |
| Bank of New York Mellon Corp | 20,232 | 14,165 | -6,067 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 51,772 | 43,295 | -8,477 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 471,617 | 461,327 | -10,290 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 10,771 | 0 | -10,771 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 156,421 | 128,676 | -27,745 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 44,185 | 0 | -44,185 | 0.01 | 0.00 | -0.01 | sell |
| NORGES BANK | 166,178 | 116,253 | -49,925 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 1,566,668 | 1,516,668 | -50,000 | 0.67 | 0.62 | -0.04 | sell |
| Altium Capital Management LLC | 429,340 | 369,126 | -60,214 | 3.12 | 2.10 | -1.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 295,000 | 200,000 | -95,000 | 0.01 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 127,785 | 0 | -127,785 | 0.00 | 0.00 | -0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,053,334 | 1,720,000 | -333,334 | 1.48 | 1.18 | -0.29 | sell |