| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 2,122,000 | +2,122,000 | 0.00 | 0.31 | +0.31 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 951,320 | +951,320 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 132,378 | 646,022 | +513,644 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 744,001 | 964,232 | +220,231 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 204,119 | +204,119 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 166,161 | +166,161 | 0.00 | 0.28 | +0.28 | buy |
| MARSHALL WACE, LLP | 28,685 | 193,491 | +164,806 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 165,446 | 322,031 | +156,585 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 71,303 | 211,050 | +139,747 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 0 | 134,619 | +134,619 | 0.00 | 0.12 | +0.12 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 26,039 | 110,178 | +84,139 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 68,504 | +68,504 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 28,900 | 62,428 | +33,528 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 29,310 | +29,310 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 14,404 | 41,200 | +26,796 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 25,169 | 48,963 | +23,794 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 19,200 | 41,580 | +22,380 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 5,400 | 26,470 | +21,070 | 0.00 | 0.00 | +0.00 | buy |
| Baker Ellis Asset Management LLC | 0 | 19,500 | +19,500 | 0.00 | 0.03 | +0.03 | buy |
| PERCEPTIVE ADVISORS LLC | 699,486 | 714,592 | +15,106 | 0.10 | 0.24 | +0.14 | buy |
| BAILARD, INC. | 0 | 12,350 | +12,350 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 10,420 | +10,420 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,732 | 6,476 | +4,744 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 895 | +895 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 445 | +445 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 0 | 179 | +179 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 104 | +104 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 11 | 48 | +37 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 40,000 | 40,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| SECTORAL ASSET MANAGEMENT INC | 800,787 | 800,787 | 0 | 2.10 | 5.81 | +3.71 | hold |
| Casdin Capital, LLC | 148,333 | 148,333 | 0 | 0.05 | 0.15 | +0.09 | hold |
| Versant Venture Management, LLC | 542,628 | 542,628 | 0 | 2.62 | 3.00 | +0.38 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,720,000 | 1,720,000 | 0 | 0.26 | 0.61 | +0.36 | hold |
| IFP Advisors, Inc | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HHLR ADVISORS, LTD. | 669,337 | 669,337 | 0 | 0.09 | 0.19 | +0.11 | hold |
| Strategies Wealth Advisors, LLC | 50,000 | 50,000 | 0 | 0.02 | 0.06 | +0.04 | hold |
| JOHNSON & JOHNSON | 1,979,173 | 1,979,173 | 0 | 2.43 | 4.61 | +2.18 | hold |
| Federation des caisses Desjardins du Quebec | 2,560 | 2,560 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Red Tree Management, LLC | 638,158 | 638,158 | 0 | 3.46 | 9.04 | +5.59 | hold |
| Cubist Systematic Strategies, LLC | 24 | 0 | -24 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 33 | 0 | -33 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 46 | 0 | -46 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 60 | 0 | -60 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 65 | 0 | -65 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 298 | 220 | -78 | 0.00 | 0.00 | +0.00 | sell |
| True Wealth Design, LLC | 124 | 38 | -86 | 0.00 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 145 | 0 | -145 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 284 | 1 | -283 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 2,744 | 1,249 | -1,495 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 1,774 | 0 | -1,774 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 4,844 | 1,834 | -3,010 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 7,455 | 1,675 | -5,780 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 10,924 | 0 | -10,924 | 0.00 | 0.00 | -0.00 | sell |
| Marex Group plc | 11,400 | 0 | -11,400 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 13,920 | 0 | -13,920 | 0.01 | 0.00 | -0.01 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 17,245 | 0 | -17,245 | 0.00 | 0.00 | -0.00 | sell |
| Samsara BioCapital, LLC | 588,816 | 571,142 | -17,674 | 0.48 | 0.88 | +0.40 | sell |
| Jain Global LLC | 19,590 | 0 | -19,590 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 388,639 | 367,645 | -20,994 | 0.00 | 0.01 | +0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 60,963 | 37,943 | -23,020 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 25,156 | 0 | -25,156 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 843,150 | 814,871 | -28,279 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 60,922 | 30,135 | -30,787 | 0.00 | 0.00 | +0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 35,156 | 0 | -35,156 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 43,200 | 0 | -43,200 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 1,698,825 | 1,655,548 | -43,277 | 0.00 | 0.00 | +0.00 | sell |
| Monaco Asset Management SAM | 75,000 | 0 | -75,000 | 0.11 | 0.00 | -0.11 | sell |
| Squarepoint Ops LLC | 89,414 | 13,086 | -76,328 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 166,799 | 77,961 | -88,838 | 0.11 | 0.09 | -0.02 | sell |
| Schonfeld Strategic Advisors LLC | 164,124 | 18,496 | -145,628 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 169,729 | 0 | -169,729 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 312,500 | 77,670 | -234,830 | 0.01 | 0.01 | -0.01 | sell |
| Saturn V Capital Management LP | 319,348 | 0 | -319,348 | 0.51 | 0.00 | -0.51 | sell |