| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Saturn V Capital Management LP | 77,297 | 573,022 | +495,725 | 0.53 | 3.29 | +2.76 | buy |
| VANGUARD GROUP INC | 461,327 | 809,083 | +347,756 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 265,833 | +265,833 | 0.00 | 0.98 | +0.98 | buy |
| BlackRock, Inc. | 404,772 | 603,577 | +198,805 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 125,995 | +125,995 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 8,967 | 82,234 | +73,267 | 0.03 | 0.25 | +0.22 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 68,320 | +68,320 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 128,676 | 188,408 | +59,732 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 116,253 | 169,729 | +53,476 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 11,136 | 39,738 | +28,602 | 0.01 | 0.04 | +0.02 | buy |
| JPMORGAN CHASE & CO | 0 | 28,426 | +28,426 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 62,717 | 89,262 | +26,545 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 26,365 | +26,365 | 0.00 | 0.00 | +0.00 | buy |
| Strategies Wealth Advisors, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 0 | 24,881 | +24,881 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 18,853 | +18,853 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 16,079 | +16,079 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 43,295 | 55,330 | +12,035 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 113,566 | 124,744 | +11,178 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 10,836 | +10,836 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 10,755 | +10,755 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 8,308 | 16,286 | +7,978 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 7,029 | +7,029 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 14,165 | 18,738 | +4,573 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,882 | 8,277 | +3,395 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3,077 | 5,860 | +2,783 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 1,300 | 3,900 | +2,600 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 3,013 | 5,215 | +2,202 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 6,042 | 8,233 | +2,191 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,087 | 3,631 | +1,544 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 480 | 943 | +463 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 420 | 783 | +363 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 80 | +80 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 13 | 78 | +65 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 29 | 31 | +2 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 680 | 680 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000 | 200,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 312,500 | 312,500 | 0 | 0.06 | 0.05 | -0.01 | hold |
| Casdin Capital, LLC | 296,666 | 296,666 | 0 | 0.38 | 0.29 | -0.09 | hold |
| Versant Venture Management, LLC | 918,163 | 918,163 | 0 | 27.64 | 15.51 | -12.14 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,720,000 | 1,720,000 | 0 | 1.18 | 0.93 | -0.25 | hold |
| Samsara BioCapital, LLC | 588,816 | 588,816 | 0 | 2.17 | 1.18 | -0.98 | hold |
| HHLR ADVISORS, LTD. | 669,337 | 669,337 | 0 | 0.28 | 0.34 | +0.06 | hold |
| JOHNSON & JOHNSON | 1,979,173 | 1,979,173 | 0 | 8.86 | 7.51 | -1.36 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 600 | 600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 240 | 240 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOR CAPITAL ADVISORS, INC. | 168 | 166 | -2 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 28 | 14 | -14 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 800,887 | 800,787 | -100 | 9.05 | 7.83 | -1.22 | sell |
| FRANKLIN RESOURCES INC | 1,447,550 | 1,445,565 | -1,985 | 0.01 | 0.01 | -0.00 | sell |
| FMR LLC | 696,927 | 691,881 | -5,046 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 6,743 | 1,317 | -5,426 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 11,142 | 0 | -11,142 | 0.00 | 0.00 | -0.00 | sell |
| Altium Capital Management LLC | 369,126 | 334,000 | -35,126 | 2.10 | 1.52 | -0.58 | sell |
| Board of Trustees of The Leland Stanford Junior University | 38,869 | 0 | -38,869 | 0.06 | 0.00 | -0.06 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 66,667 | 0 | -66,667 | 0.01 | 0.00 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 1,516,668 | 1,441,249 | -75,419 | 0.62 | 0.59 | -0.03 | sell |
| Squarepoint Ops LLC | 350,000 | 217,239 | -132,761 | 0.02 | 0.01 | -0.01 | sell |
| Polar Capital Holdings Plc | 216,601 | 43,604 | -172,997 | 0.02 | 0.00 | -0.02 | sell |