| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 0 | 2,448,979 | +2,448,979 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 77,670 | 1,420,838 | +1,343,168 | 0.01 | 0.10 | +0.09 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,720,000 | 2,841,334 | +1,121,334 | 0.61 | 0.81 | +0.20 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 951,320 | 1,842,800 | +891,480 | 0.02 | 0.04 | +0.02 | buy |
| Commodore Capital LP | 0 | 816,326 | +816,326 | 0.00 | 0.62 | +0.62 | buy |
| GREAT POINT PARTNERS LLC | 0 | 800,000 | +800,000 | 0.00 | 2.96 | +2.96 | buy |
| PERCEPTIVE ADVISORS LLC | 714,592 | 1,464,592 | +750,000 | 0.24 | 0.31 | +0.06 | buy |
| Boxer Capital Management, LLC | 0 | 494,000 | +494,000 | 0.00 | 1.24 | +1.24 | buy |
| Longaeva Partners L.P. | 0 | 470,000 | +470,000 | 0.00 | 0.64 | +0.64 | buy |
| Point72 Asset Management, L.P. | 367,645 | 759,227 | +391,582 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 964,232 | 1,270,858 | +306,626 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 282,874 | +282,874 | 0.00 | 0.42 | +0.42 | buy |
| FRANKLIN RESOURCES INC | 1,655,548 | 1,879,367 | +223,819 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 322,031 | 536,155 | +214,124 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 209,633 | +209,633 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 77,961 | 278,961 | +201,000 | 0.09 | 0.24 | +0.15 | buy |
| MILLENNIUM MANAGEMENT LLC | 646,022 | 830,687 | +184,665 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 173,475 | +173,475 | 0.00 | 0.41 | +0.41 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 166,161 | 307,540 | +141,379 | 0.28 | 0.51 | +0.23 | buy |
| Monashee Investment Management LLC | 0 | 137,430 | +137,430 | 0.00 | 0.89 | +0.89 | buy |
| UBS Group AG | 68,504 | 199,389 | +130,885 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 91,442 | +91,442 | 0.00 | 0.09 | +0.09 | buy |
| GOLDMAN SACHS GROUP INC | 30,135 | 105,594 | +75,459 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 72,494 | +72,494 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 220 | 64,228 | +64,008 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 204,119 | 265,761 | +61,642 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 2,122,000 | 2,179,711 | +57,711 | 0.31 | 0.26 | -0.05 | buy |
| BARCLAYS PLC | 6,476 | 59,507 | +53,031 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 51,028 | +51,028 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 43,078 | +43,078 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 26,470 | 64,705 | +38,235 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 34,900 | +34,900 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 29,310 | 59,031 | +29,721 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 27,945 | +27,945 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 25,938 | +25,938 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 23,377 | +23,377 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 62,428 | 84,428 | +22,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 19,522 | +19,522 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 19,426 | +19,426 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 17,074 | +17,074 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 41,200 | 57,100 | +15,900 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 15,036 | +15,036 | 0.00 | 0.01 | +0.01 | buy |
| Persistent Asset Partners Ltd | 0 | 13,853 | +13,853 | 0.00 | 0.08 | +0.08 | buy |
| CITIGROUP INC | 0 | 12,324 | +12,324 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 11,300 | +11,300 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 41,580 | 49,280 | +7,700 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 48,963 | 53,876 | +4,913 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 18,496 | 22,673 | +4,177 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 3,764 | +3,764 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 134,619 | 137,493 | +2,874 | 0.12 | 0.09 | -0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 211,050 | 213,869 | +2,819 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,122 | +1,122 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 0 | 454 | +454 | 0.00 | 0.00 | +0.00 | buy |
| Banque Transatlantique SA | 0 | 220 | +220 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 800,787 | 800,787 | 0 | 5.81 | 7.34 | +1.53 | hold |
| Casdin Capital, LLC | 148,333 | 148,333 | 0 | 0.15 | 0.11 | -0.04 | hold |
| Versant Venture Management, LLC | 542,628 | 542,628 | 0 | 3.00 | 4.11 | +1.10 | hold |
| HHLR ADVISORS, LTD. | 669,337 | 669,337 | 0 | 0.19 | 0.25 | +0.05 | hold |
| Optiver Holding B.V. | 104 | 104 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fortitude Family Office, LLC | 445 | 445 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Strategies Wealth Advisors, LLC | 50,000 | 50,000 | 0 | 0.06 | 0.06 | -0.00 | hold |
| JOHNSON & JOHNSON | 1,979,173 | 1,979,173 | 0 | 4.61 | 4.08 | -0.54 | hold |
| Federation des caisses Desjardins du Quebec | 2,560 | 2,560 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Red Tree Management, LLC | 638,158 | 638,158 | 0 | 9.04 | 6.69 | -2.35 | hold |
| FMR LLC | 814,871 | 814,871 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 37,943 | 37,916 | -27 | 0.00 | 0.00 | -0.00 | sell |
| True Wealth Design, LLC | 38 | 0 | -38 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 48 | 0 | -48 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 1,249 | 1,180 | -69 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 110,178 | 110,061 | -117 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 500 | 103 | -397 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 895 | 0 | -895 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,675 | 124 | -1,551 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 10,420 | 0 | -10,420 | 0.00 | 0.00 | -0.00 | sell |
| BAILARD, INC. | 12,350 | 0 | -12,350 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 193,491 | 180,804 | -12,687 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 13,086 | 0 | -13,086 | 0.00 | 0.00 | -0.00 | sell |
| Baker Ellis Asset Management LLC | 19,500 | 0 | -19,500 | 0.03 | 0.00 | -0.03 | sell |
| RBF Capital, LLC | 40,000 | 20,000 | -20,000 | 0.02 | 0.01 | -0.01 | sell |
| Samsara BioCapital, LLC | 571,142 | 72,245 | -498,897 | 0.88 | 0.09 | -0.79 | sell |